Multiscale Mechanobiology of Bone Remodeling and Adaptation PDF Download

Author: Peter Pivonka
Publisher: Springer
ISBN: 3319588451
Category : Science
Languages : en
Pages : 295

View

Book Description
The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Author: Stefaan Verbruggen
Publisher: Academic Press
ISBN: 0128129530
Category : Medical
Languages : en
Pages : 530

View

Book Description
Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. - Provides an essential digest of primary research from many fields and disciplines in one convenient volume - Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives - Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Author: Lutz E. Claes
Publisher: Springer Nature
ISBN: 3030940829
Category : Technology & Engineering
Languages : en
Pages : 104

View

Book Description
This book offers a summary of research on the biomechanics of fracture fixation and mechanobiology of fracture healing. The author, a known expert, provides an overview of the state of art, his own research together with that of his co-workers and collaborators; he describes the ideas and findings from the beginning of this research field in the 1960s up to the clinical consequences and applications of today. The book discusses the mechanobiology of fracture healing, illustrates the numerical methods that simulate fracture healing processes, and depicts specific research methods of experimental studies. Finally, it provides conclusions for the improvement of fracture treatment that will be of use in clinical applications nowadays. This book will be a valuable resource of knowledge for students and scientists in the field of bioengineering, experimental biology, and biomechanics, helping them to identify the correct conditions and analysis for their respective research and receive an understanding of the research field from its beginning until today. For experimental and clinical surgeons active in the field of fracture healing, this book will provide a useful historical overview over this translational research field.

Author: Anand J. Thakur
Publisher: Elsevier Health Sciences
ISBN: 8131242374
Category : Medical
Languages : en
Pages : 421

View

Book Description
Timely, accurate, and up-to-date text clearly explaining the fundamentals of fracture healing and bone fixation in a format that is concise, well organized and easy to follow. It is extremely well illustrated and addresses the biomechanical principles and usage techniques of the wide range of modern orthopaedic trauma implants in use today.• An in-depth resource to the amply stocked tool-box of today's fracture surgeon• A compendium of fracture fixation written by an experienced surgeon for fellows, residents and masters• A detailed overview of biomechanics, biology, implants and materials relevant to fracture care• Elegantly illustrated and lucidly explained presentations of today's fracture fixation devices• The designs, the application techniques in various anatomical regions, mechanical effects, hazards and contraindications are described along elucidative graphics• Not so commonly found details of intramedullary nail and use of Poller screws in its insertion, hazards of use of traction table, methods to perfect insertion of intramedullary hip fixation device, minute details of cables, pins and wires, several configurations of external fixator, new concept of reverse dynamization, a brief exposure of spinal instrumentation and several techniques of minimal invasive osteosynthesis are a few of its features

Author: Glen L. Niebur
Publisher: Elsevier
ISBN: 0128179325
Category : Science
Languages : en
Pages : 256

View

Book Description
Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. - Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli - Provides a review of diseases with known or purported mechanobiological underpinnings - Includes the role of mechanobiology in tissue engineering and regenerative medicine - Covers experimental methods to capture mechanobiological phenomena

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309132991
Category : Business & Economics
Languages : en
Pages : 510

View

Book Description
Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.

Author: Van C Mow
Publisher: Lippincott Raven
ISBN: 9780397516841
Category : Biomechanics
Languages : en
Pages : 0

View

Book Description
This classic text has been completely revised and updated to reflect the latest advances in orthopaedic biomechanics, and the successful application of mechanical laws to the locomotor system of the human body. The Second Edition features new chapters on cell-matrix interactions in articular cartilage and on the quantitative anatomy of diarthrodial joints, as well as expanded coverage of the biomechanics of artificial hip and knee joints.

Author: Sarah M. Greising
Publisher: Springer Nature
ISBN: 3030958841
Category : Medical
Languages : en
Pages : 462

View

Book Description
This contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field.

Author: James D. Adams
Publisher: Royal Society of Chemistry
ISBN: 1849731608
Category : Medical
Languages : en
Pages : 319

View

Book Description
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.

Author: David W. Smith
Publisher: Springer
ISBN: 9811314748
Category : Technology & Engineering
Languages : en
Pages : 784

View

Book Description
This book explains the anatomy and physiology of cartilage tissue in an integrated way. The emphasis is on how cartilage tissue functions and maintains homeostasis in a challenging mechanical environment. Supported by hundreds of references, the book posts new hypotheses explaining how cartilage adapts and achieves homeostasis in vivo, and tests them against available data. This exploratory approach creates a sense of discovery that the reader can join, or perhaps test themselves through their own research. The main benefit will be obtained by research students and professors looking to understand the deeper concepts that will further their own research, or clinicians (including health professionals and surgeons) who want to gain a deeper physiological understanding of cartilage tissue, which can then serve as a basis for more rational clinical decision-making they need to make on a daily basis. To help bridge the gap between basic science and clinically relevant joint disease, applications and interpretations of key physiological concepts are discussed in the context of osteoarthritis at the end of most chapters.