Author: Yanping XuPublisher:
ISBN:
Category :
Languages : en
Pages : 358
Book Description
Mechanisms of Stimulus-secretion Coupling in Porcine Adrenal Chromaffin Cells
Author: Yanping XuResearch Awards Index
Author: ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology
Author: Nicole Gallo-PayetPublisher: Frontiers Media SA
ISBN: 2889452328
Category : ACTH.
Languages : en
Pages : 421
Book Description
By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.
Biomedical Index to PHS-supported Research
Author: Research Grants Index
Author: National Institutes of Health (U.S.). Division of Research GrantsPublisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1498
Book Description
The Adrenal Medulla 1986-1988
Author: Stephen W. CarmichaelPublisher: CRC Press
ISBN: 1351357328
Category : Medical
Languages : en
Pages : 602
Book Description
This volume provides a complete review of all the articles which have appeared in the literature since 1986 that pertain to the adrenal medulla and adrenal chromaffin. Over 1700 articles are reviewed, organized, and summarized. Topics covered include the transplantation of medulla into the brain, stimulus-secretion coupling, neuropeptides, enzymes of catecholamine biosynthesis, growth factors, neural regulation and clinical considerations, including imaging and tumors. This book will provide interesting reading for neurobiologists, cell biologists, pathologists, diagnostic radiologists, and advanced biology students.
Cumulated Index Medicus
Author: What's New in Endocrinology?
Author: Jeff M. P. HollyPublisher: Frontiers Media SA
ISBN: 2889633926
Category :
Languages : en
Pages : 163
Book Description
Mechanisms of Release of Biogenic Amines
Author: U. S. Von EulerPublisher: Elsevier
ISBN: 1483149145
Category : Science
Languages : en
Pages : 491
Book Description
Wenner-Gren Center International Symposium Series, Volume 5: Mechanisms of Release of Biogenic Amines provides information pertinent to the fundamental aspects of the release of biogenic amines. This book discusses the physiology, biochemistry, and pharmacology of the biogenic amines. Organized into 39 chapters, this volume begins with an overview of the release of amines, which is implicated in functional disturbances characteristic of different diseases. This text then examines the concepts of cell structure that are significant to the release of neurohumoral agents. Other chapters consider the fluorescence reaction, which made it possible to work out a practical histochemical procedure. This book describes as well a few examples in which the monoaminergic transmitter is not revealed as a diffuse cytoplasmic fluorescence. The final chapter deals with acetylcholine as the only brain amine investigated, which could be influenced by the tremorgenic agents during the period of tremor. This book is a valuable resource for biochemists, morphologists, pharmacologists, and physiologists.
Author: