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Author: N.J. Vianna Publisher: Springer Science & Business Media ISBN: 9401180539 Category : Medical Languages : en Pages : 139
Book Description
No disease can exist by itself but rather each must be viewed as the result of some specific interaction between man and his environment. This fact is appreciated even by people in the most primitive of civilisations and prompts them to ask the basic question: 'Why did I develop this disease'? The astute clinician goes beyond establishing a diagnosis and asks similar questions of himself and his patient. Frequently a singular observation resulting from this type of inquiry provides the working hypothesis for the epidemiologist who again asks the same question, not of the individual but of a definable population at risk. As a science, epidemiology is bound to the laws of logic and statistics, but clearly it must go beyond this point. The epidemiologist faced with a statistic ally significant observation must also question" its biologic relevance. He must evaluate the consistency of his findings with the more estab lished features of the disease under study. He must also be sufficiently imaginative to challenge his results with additional studies, different in their methodologic approach; and, of great importance, he must have the courage to be wrong. But epidemiologic studies alone can never determine the specific aetiology of a disease. Other scientific disciplines with their own inherent limitations are also required. Thus, in cancer research, the laboratory investigator frequently employs animal models, but the applicability of results obtained to humans is always subject to question.
Author: N.J. Vianna Publisher: Springer Science & Business Media ISBN: 9401180539 Category : Medical Languages : en Pages : 139
Book Description
No disease can exist by itself but rather each must be viewed as the result of some specific interaction between man and his environment. This fact is appreciated even by people in the most primitive of civilisations and prompts them to ask the basic question: 'Why did I develop this disease'? The astute clinician goes beyond establishing a diagnosis and asks similar questions of himself and his patient. Frequently a singular observation resulting from this type of inquiry provides the working hypothesis for the epidemiologist who again asks the same question, not of the individual but of a definable population at risk. As a science, epidemiology is bound to the laws of logic and statistics, but clearly it must go beyond this point. The epidemiologist faced with a statistic ally significant observation must also question" its biologic relevance. He must evaluate the consistency of his findings with the more estab lished features of the disease under study. He must also be sufficiently imaginative to challenge his results with additional studies, different in their methodologic approach; and, of great importance, he must have the courage to be wrong. But epidemiologic studies alone can never determine the specific aetiology of a disease. Other scientific disciplines with their own inherent limitations are also required. Thus, in cancer research, the laboratory investigator frequently employs animal models, but the applicability of results obtained to humans is always subject to question.
Author: Frederick Becker Publisher: Springer Science & Business Media ISBN: 1468427369 Category : Medical Languages : en Pages : 446
Book Description
As was shown in the first two volumes of this series, great strides have been made in identifying many of the agents or classes of substances responsible for carcinogenesis and in delineating their interactions with the cell. Clearly, the aim of such studies is that, once identified, these agents can be eliminated from the environment. Yet, despite these advances and the elimination of some important carcinogenic agents, one major problem exists. It is a constant monitor of all oncologic study and diminishes the importance of every experiment and of every clinical observation. As we noted earlier, that problem is our inability to define the malignant cell. It is through studies of the fundamental biology of tumors that we seek this definition. A vast amount of information has been gathered which describes what this cell does and-to a lesser extent-how it does it. But the why evades us. We have been unable to define the malignant cell, save in broad terms by comparing it to its normal counterpart. The major problem appears to be that the malignant cell does so much. It is a chimera, mystifyingly composed of normal activities and structures, of phenotypic schizophrenia with embryonic, fetal, and adult charac teristics and, occasionally, a hint of an unclassifiable capacity unique to malignant cells.
Author: Ann Arvin Publisher: Cambridge University Press ISBN: 1139461648 Category : Medical Languages : en Pages : 1325
Book Description
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author: S.H. Faderl Publisher: Springer Science & Business Media ISBN: 3540723048 Category : Medical Languages : en Pages : 302
Book Description
Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.
Author: N.J. Vianna
Author: N.J. Vianna
Author: Frederick Becker
Author: Alecsandru Ioan Baba
Author: 
Author: Ann Arvin
Author: 
Author: S.H. Faderl
Author: J. Whitehouse
Author: May Sherman
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