Author: P. Van Schil
Publisher: Nova Publishers
ISBN: 9781594544507
Category : Isolation perfusion (Physiology)
Languages : en
Pages : 254
Book Description
Surgical resection of lung metastases is a widely accepted procedure but long-term results are disappointing with a 5-year survival rate of approximately 40%. The main prognostic factor is complete resection and a better survival is reported in patients with a single metastasis and a disease-free survival of more than 3 years. Re-operations are feasible but often patients become inoperable due to insufficient pulmonary reserve and new treatment modalities are looked for. Intravenous (iv) chemotherapy has no major impact on survival due to systemic side-effects when high doses are given. As isolated limb and liver perfusion, isolated lung perfusion (ILuP) has the advantage of selectively delivering an agent into the lung while diverting the venous effluent. This allows the drug to be given in a significantly higher dose compared to iv therapy, while drug levels in the other organs are kept low enough to avoid major complications. ILuP has been shown to be very effective for the treatment of lung metastases in animal models. Phase I clinical studies to determine dose-limiting toxicity and maximum tolerated dose have recently been reported. The principal aim of this book is to discuss the current treatment of lung metastases and the possible contribution of ILuP.
Lung Metastases and Isolated Lung Perfusion
Author: P. Van Schil
Publisher: Nova Publishers
ISBN: 9781594544507
Category : Isolation perfusion (Physiology)
Languages : en
Pages : 254
Book Description
Surgical resection of lung metastases is a widely accepted procedure but long-term results are disappointing with a 5-year survival rate of approximately 40%. The main prognostic factor is complete resection and a better survival is reported in patients with a single metastasis and a disease-free survival of more than 3 years. Re-operations are feasible but often patients become inoperable due to insufficient pulmonary reserve and new treatment modalities are looked for. Intravenous (iv) chemotherapy has no major impact on survival due to systemic side-effects when high doses are given. As isolated limb and liver perfusion, isolated lung perfusion (ILuP) has the advantage of selectively delivering an agent into the lung while diverting the venous effluent. This allows the drug to be given in a significantly higher dose compared to iv therapy, while drug levels in the other organs are kept low enough to avoid major complications. ILuP has been shown to be very effective for the treatment of lung metastases in animal models. Phase I clinical studies to determine dose-limiting toxicity and maximum tolerated dose have recently been reported. The principal aim of this book is to discuss the current treatment of lung metastases and the possible contribution of ILuP.
Publisher: Nova Publishers
ISBN: 9781594544507
Category : Isolation perfusion (Physiology)
Languages : en
Pages : 254
Book Description
Surgical resection of lung metastases is a widely accepted procedure but long-term results are disappointing with a 5-year survival rate of approximately 40%. The main prognostic factor is complete resection and a better survival is reported in patients with a single metastasis and a disease-free survival of more than 3 years. Re-operations are feasible but often patients become inoperable due to insufficient pulmonary reserve and new treatment modalities are looked for. Intravenous (iv) chemotherapy has no major impact on survival due to systemic side-effects when high doses are given. As isolated limb and liver perfusion, isolated lung perfusion (ILuP) has the advantage of selectively delivering an agent into the lung while diverting the venous effluent. This allows the drug to be given in a significantly higher dose compared to iv therapy, while drug levels in the other organs are kept low enough to avoid major complications. ILuP has been shown to be very effective for the treatment of lung metastases in animal models. Phase I clinical studies to determine dose-limiting toxicity and maximum tolerated dose have recently been reported. The principal aim of this book is to discuss the current treatment of lung metastases and the possible contribution of ILuP.
Isolated Lung Perfusion for the Treatment of Pulmonary Metastases
Pulmonary Metastasectomy, An Issue of Thoracic Surgery Clinics of North America
Author: Mark W. Onaitis
Publisher: Elsevier Health Sciences
ISBN: 0323417175
Category : Medical
Languages : en
Pages : 145
Book Description
This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more!
Publisher: Elsevier Health Sciences
ISBN: 0323417175
Category : Medical
Languages : en
Pages : 145
Book Description
This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more!
Isolated Lung Perfusion with Gemcitabine for the Treatment of Pulmonary Metastases
Author: Bart P. van Putte
Publisher:
ISBN: 9789039334799
Category :
Languages : en
Pages : 167
Book Description
Publisher:
ISBN: 9789039334799
Category :
Languages : en
Pages : 167
Book Description
Pulmonary Metastases
Author: Jeroen M.H. Hendriks
Publisher:
ISBN:
Category :
Languages : en
Pages : 135
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 135
Book Description
Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases
Author: Pedro Augusto Reck dos Santos
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Pulmonary Metastasis
Author: Leonard Weiss
Publisher: Macmillan Reference USA
ISBN:
Category : Medical
Languages : en
Pages : 362
Book Description
Publisher: Macmillan Reference USA
ISBN:
Category : Medical
Languages : en
Pages : 362
Book Description
Current Surgical Management of Pulmonary Metastases
Author: Robert J. Downey
Publisher:
ISBN: 9781416035602
Category : Lungs
Languages : en
Pages : 0
Book Description
Articles in this issue will cover everything from the biology of metastases to surgical approaches, to surgical outcomes. Other articles will address adjuvant therapy, lymphadenectomy, lung perfusion, and the pediatric patient.
Publisher:
ISBN: 9781416035602
Category : Lungs
Languages : en
Pages : 0
Book Description
Articles in this issue will cover everything from the biology of metastases to surgical approaches, to surgical outcomes. Other articles will address adjuvant therapy, lymphadenectomy, lung perfusion, and the pediatric patient.
Regional Chemotherapy of the Lung
Author: M. J. J. H. Grootenboers
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Regional chemotherapy of the lung
Author: Marco Grootenboers
Publisher:
ISBN: 9789090226347
Category :
Languages : nl
Pages : 147
Book Description
Publisher:
ISBN: 9789090226347
Category :
Languages : nl
Pages : 147
Book Description