GABA and the Basal Ganglia PDF Download

Author: J. M. Tepper
Publisher: Elsevier
ISBN: 0080480470
Category : Medical
Languages : en
Pages : 350

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Book Description
Over the past 25 years the amount of data pertaining to the GABAergic function in the basal ganglia has increased dramatically. GABA and the Basal Ganglia - From Molecules to Systems is a comprehensive review of the current state-of-the-art of knowledge about the neuroanatomy, neuropharmacology and neurophysiology of the basal ganglia, focusing on its GABAergic microcircuitry. It serves as a complete reference to the body of knowledge about the basal ganglia, its constituent neurons, and their interconnections. This volume is designed to serve as a convenient all-in-one review and reference for experienced basal ganglia researchers as well as an introduction to the functional organization of the basal ganglia and its GABAergic circuitry for students and researchers new to the field.* Reviews the anatomy, physiology and pharmacology of the basal ganglia itself in addition to focusing on the GABAergic circuitry of the basal ganglia* Authors of each chapter leading internationally acclaimed experts in basal ganglia research

Author: Jeffrey Noebels
Publisher: OUP USA
ISBN: 0199746540
Category : Medical
Languages : en
Pages : 1258

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Book Description
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Author: Kristy Kultas-Ilinsky
Publisher: Springer Science & Business Media
ISBN: 1461512352
Category : Medical
Languages : en
Pages : 370

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Book Description
This volume is comprised of the majority of lecture presentations and a few select posters presented at the International Workshop, "Basal Ganglia and Thalamus in Health and Movement Disorders," held in Moscow, Russia, on May 29-31, 2000. The International Committee responsible for organizing this workshop included Alexander Konovalov, Director, Burdenko Institute of Neurosurgery of the Russian Academy of Medical Sciences, Mahlon DeLong, Chair, Department of Neurology, Emory University, Atlanta, USA, Alim Louis Benabid, Chief, Neurosurgery Service, University of Joseph Fourrier, Grenoble, France, and the two undersigned. The workshop was conceived out of a desire to provide a forum for discussions of both basal ganglia-and motor thalamus-related issues by bringing together basic scientists and clinicians representing different disciplines, research directions, and philosophies. The primary goals were to encourage an exchange of information and ideas in an informal environment, to stimulate integration of the data from different disciplines, and to identifY controversial issues and the most essential questions to be addressed in future research.

Author:
Publisher: Academic Press
ISBN: 012802691X
Category : Science
Languages : en
Pages : 285

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Book Description
Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part B, a new volume of Advances in Pharmacology, presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years, which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development. - Contributions from the best authors in the field - An essential resource for pharmacologists, immunologists, and biochemists

Author: Udo Rüb
Publisher: Springer
ISBN: 331919285X
Category : Medical
Languages : en
Pages : 154

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Book Description
This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

Author: Janko Samardzic
Publisher: BoD – Books on Demand
ISBN: 9535138219
Category : Medical
Languages : en
Pages : 139

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Book Description
This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Author: Adam C. Errington
Publisher: Springer
ISBN: 149391426X
Category : Medical
Languages : en
Pages : 301

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Book Description
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Author: Davide Martino
Publisher: Oxford University Press
ISBN: 0197543219
Category : Medical
Languages : en
Pages : 577

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Book Description
Tourette syndrome (TS) has become increasingly recognised within society and has gained scientific interest worldwide. Knowledge of its clinical presentation, mechanisms of disease, and available treatment approaches has increased remarkably over the last two decades. Likewise, the way clinicians, teachers, social care workers, and families face the problems manifested by patients with TS is rapidly evolving. Tourette Syndrome, edited by Davide Martino and James F. Leckman, offers a unique opportunity to capture this knowledge advance through a comprehensive and up-to-date overview. Tourette Syndrome covers all the main aspects related to TS, analyzing its complex clinical presentation, the novel viewpoints of causes and mechanisms, state-of-the-art assessment techniques, and the diversity of treatment options. Multidisciplinarity is the main asset of this volume, which represents a source of consultation for a wide audience of professionals, integrated with video tutorials related to particularly complex areas of patient management. Medical and PhD students, as well as post-doctoral scientists, will be able to use the volume as a valuable learning source.

Author: N. J. Strausfeld
Publisher: Springer Science & Business Media
ISBN: 3642821154
Category : Medical
Languages : en
Pages : 445

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Book Description
The "functional" in the title of this book not only reflects my personal bias about neuroanatomy in brain research, it is also the gist of many chapters which describe sophisticated ways to resolve structures and interpret them as dynamic entities. Examples are: the visualization of functionally identified brain areas or neurons by activity staining or intracellular dye-iontophoresis; the resolution of synaptic connections between physiologically identified nerve cells; and the biochemical identification of specific neurons (their peptides and transmitters) by histo- and immunocytochemistry. I personally view the nervous system as an organ whose parts, continuously exchanging messages, arrive at their decisions by the cooperative phenome non of consensus and debate. This view is, admittedly, based on my own ex perience of looking at myriads of nerve cells and their connections rather than studying animal behaviour or theorizing. Numerous structural studies have demonstrated that interneurons in the brain must receive hundreds of thousands of synapses. Many neurons receive inputs from several different sensory areas: each input conveys a message about the external world and possibly also about past events which are stored within the central nervous system. Whether an interneuron responds to a certain combination of inputs may be, literally, a matter of debate whose outcome is decided at the post synaptic membrane. A nerve cell responding to an overriding command is possibly a rare event.

Author: K. Fuxe
Publisher: Elsevier
ISBN: 1483103099
Category : Science
Languages : en
Pages : 629

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Book Description
Trophic Regulation of the Basal Ganglia: Focus on Dopamine Neurons examines neurotransmitters. The book first discusses the role of fibroblast growth factor-2 (FGF-2) and ganglioside GM1 and the trophic regulation of the basal ganglia. Biochemical and histochemical studies on the cellular localization of FGF-2; mapping of FGF-2 and its receptors in the basal ganglia postnatally and adulthood; and mapping of the ganglioside GM1 distribution in the basal ganglia are presented. The text also explains glucocorticoid and estrogen effects on the nigrostriatal and mesolimbic dopaminergic systems; factors associated to dopaminergic cell death in Parkinson's disease; and compensatory mechanisms at dopamine D-2 receptors. The book also describes the effects of brain-derived neurotrophic factor on injured dopaminergic neurons; role of gangliosides and trophic factors in brain repair; and features of the trophic action of polyamines. The text also underscores the presence of interleukin-1 in the central nervous system; neuropeptides synthesis in astrocytes; and astrocytic kynurenines as modulators of dopaminergic function in the rat basal ganglia. The selection is a good source of information for readers wanting to study neurotransmitters.