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Author: Sandra Knowles Weller Publisher: Caister Academic Press Limited ISBN: 9781904455769 Category : Science Languages : en Pages : 0
Book Description
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Author: Sandra Knowles Weller Publisher: Caister Academic Press Limited ISBN: 9781904455769 Category : Science Languages : en Pages : 0
Book Description
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Author: William Gilbert Publisher: Lulu.com ISBN: 1326494465 Category : Science Languages : en Pages : 160
Book Description
This 'On The Magnet' is a new improved English translation of the widely censored or banned Latin 1600 'De Magnete' by William Gilbert which was the first real science book to be published. This version is rather easier to read than its two earlier translations, and significantly helps to clarify Gilbert's 'attraction' physics which Newton put as one of two basic valid mathematized physics options and which he is believed to have privately favoured. It is basically a novel signal-response or remote-control physics that may still have real relevance today.
Author: David Ward Publisher: Fairleigh Dickinson Univ Press ISBN: 9780838636763 Category : History Languages : en Pages : 260
Book Description
This book is an in-depth analysis of three of the most crucial years in twentieth-century Italian history, the years 1943-46. After more than two decades of a Fascist regime and a disastrous war experience during which Italy changed sides, these years saw the laying of the political and cultural foundations for what has since become known as Italy's First Republic. Drawing on texts from the literature, film, journalism, and political debate of the period, Antifascisms offers a thorough survey of the personalities and positions that informed the decisions taken in this crucial phase of modern Italian history.
Author: Sandra Knowles Weller
Author: Sandra Knowles Weller
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Author: William Gilbert
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Author: David Ward
Author: Euripides
Author: Philostratus (the Athenian)
Author: Horace Fletcher
Author: Kenneth Grant
Author: Alessandra Ceretto