Proteomics for Drug Discovery PDF Download

Author: Josip Blonder
Publisher: Springer Nature
ISBN: 1071639226
Category :
Languages : en
Pages : 315

View

Book Description

Author: Andrew G. Stephen
Publisher: Springer Nature
ISBN: 107163822X
Category : Cancer
Languages : en
Pages : 367

View

Book Description
"This volume details protocols ranging from high yield production metabolically labeled KRAS for NMR studies to approaches that quantify engagement of novel molecules that bind KRAS in live cells. Chapters focus on protein production and characterization, biochemical assays, cell-based assays, KRAS-membrane interactions, targeting KRAS, and cell models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, KRAS: Methods and Protocols aims to provide methods that will be instrumental in the development of future clinically approved KRAS therapeutics"--Back cover.

Author: Ian W.J. Carter
Publisher: Springer Science & Business Media
ISBN: 9048190398
Category : Science
Languages : en
Pages : 420

View

Book Description
Not another textbook, but a valuable tool for doctors and microbiologists wanting to know how to set up a PCR diagnostic microbiology laboratory according to current regulatory standards and perform assays supplied with patient clinical diagnostic criteria and easy to follow protocols. Whether laboratories are using commercial kits or in-house methods developed in their own laboratories or adopted from published methods, all clinical microbiology laboratories need to be able to understand, critically evaluate, perform and interpret these tests according to rigorous and clinically appropriate standards and international guidelines. The cost and effort of development and evaluation of in-house tests is considerable and many laboratories do not have the resources to do so. This compendium is a vehicle to improve and maintain the clinical relevance and high quality of diagnostic PCR. It is a unique collection of; guidelines for PCR laboratory set up and quality control, test selection criteria, methods and detailed step by step protocols for a diagnostic assays in the field of molecular microbiology. The structure of the book provides the PCR fundamentals and describes the clinical aspects and diagnosis of infectious disease. This is followed by protocols divided into; bacteria, virus, fungi and parasites, and susceptibility screens. The inclusion of medical criteria and interpretation adds value to the compendium and benefits clinicians, scientists, researchers and students of clinical diagnostic microbiology

Author: Ana Varela Coelho
Publisher: BoD – Books on Demand
ISBN: 9535111361
Category : Medical
Languages : en
Pages : 208

View

Book Description
Tandem Mass Spectrometry - Molecular Characterization presents a comprehensive coverage of theory, instrumentation and description of experimental strategies and MS/MS data interpretation for the structural characterization of relevant molecular compounds. The areas covered include the analysis of drugs, metabolites, carbohydrates and protein post-translational modifications. The book series in Tandem Mass Spectrometry serves multiple groups of audiences; professional (academic and industry), graduate students and general readers interested in the use of modern mass spectrometry in solving critical questions of chemical and biological sciences.

Author: Helen B. Needham
Publisher: PublishAmerica
ISBN: 9781451276176
Category : Humor
Languages : en
Pages : 254

View

Book Description

Author: Kerstin Kaufmann
Publisher: Springer Nature
ISBN: 1071633546
Category :
Languages : en
Pages : 380

View

Book Description

Author: Ezra Berman
Publisher:
ISBN:
Category : Cats
Languages : en
Pages : 644

View

Book Description
Some 2300 references to scientific books, journal articles, and miscellaneous publications about the domestic cat. Also includes some foreign-language citations. Both retrospective and current. Entries include abstract numbers, bibliographical information, and abstracts that vary in length. Author, subject (descriptors) indexes.

Author: S. Wayne Hall
Publisher: Page Publishing Inc
ISBN: 1645840093
Category : Fiction
Languages : en
Pages : 255

View

Book Description
Tom Beckway is retired. In his younger years, he had a brief but extremely successful career in law enforcement. Because small-town police departments could not afford to pay their officers very well and because he had a young family, Tom made the decision to leave law enforcement. He took one manufacturing job after another, raised and educated his children, and now at the age of sixty, is comfortably retired. The concept is important to him. With lots of free time on his hands, Tom starts a business called Tom's Answers and Solutions. Using his dated but significant law enforcement training and experience, he put together a resume and distributed it to local law firms and insurance companies. When they need to locate a witness, or if they are in need of a sworn witness's statement, Tom is the man for the job. In this case, Tom is hired to get a witness statement from the sister of a recently arrested man. Sounds simple, but Tom soon finds himself in the middle of a double murder and all kinds of small-town intrigue. With the knowledge that his estranged wife is on her way to Indiana for a surprise visit burning in the back of his mind, and with the help of his live-in brother-in-law, and despite the misadventures of his mean-as-a-snake cat, LC, Tom Beckway is determined to find the answer or solution.

Author:
Publisher: Elsevier
ISBN: 0443185859
Category : Science
Languages : en
Pages : 512

View

Book Description
Biochemical Pathways and Environmental Responses in Plants, Part B, Volume 682 in the Methods in Enzymology series, highlights advances in the field with this new volume presenting chapters on MIE 681/682: Biochemical pathways and environmental responses in plants, Structure, function, and engineering of plant polyketide synthases, A sensitive LC-MS/MS assay for enzymatic characterization of methylthioalkylmalate synthase involved in glucosinolate side-chain elongation, Assaying formate-tetrahydrofolate ligase with monoglutamylated and polyglutamylated substrates using a fluorescence-HPLC based assay, An Approach to Nearest Neighbor Analysis of Pigmented Protein Complexes by Using Chemical Crosslinking in Combination with Mass Spectrometry, Biochemical characterization of plant aromatic aminotransferases, and much more. Other chapters focus on Functional Analysis of Phosphoethanolamine N-methyltransferase (PMT) in Plants and Parasites, A structure-guided computational screening approach for predicting plant enzyme-metabolite interactions, Plant metacaspase: an example of microcrystal structure determination and analysis, Biocatalytic system for comparative assessment of functional association of cytochrome P450 monooxygenases with their redox partners, Dirigent Protein Family Function and Structure, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology series - Includes the latest information on Biochemical pathways and environmental responses in plants

Author: United States. Department of State
Publisher:
ISBN:
Category :
Languages : en
Pages : 904

View

Book Description