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Author: Timo Partonen Publisher: Frontiers Media SA ISBN: 2889454517 Category : Languages : en Pages : 117
Book Description
"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”
Author: Timo Partonen Publisher: Frontiers Media SA ISBN: 2889454517 Category : Languages : en Pages : 117
Book Description
"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called "clock genes."
Author: Jay C. Dunlap Publisher: Sinauer Associates Incorporated ISBN: 9780878931491 Category : Science Languages : en Pages : 406
Book Description
The study of how solar- and lunar- related rhythms are governed by living pacemakers within organisms constitutes the scientific discipline of chronobiology. Few fields encompass the breadth of science that is associated with this subject, which is at the cutting edge of fields ranging from microbial genetics to ethology to treatment of human psychiatric illnesses. In order to recognise that no individual could do justice to the field in writing a comprehensive text, a group of experienced editors and contributors have collaborated to produce Chronobiology. Written in a clear style and fully illustrated to elucidate difficult points, the book assumes no previous background in neuroscience or maths and reduces technical terminology to a minimum. Examples from the real world and from current and classic research are included.
Author: Derek J. Chadwick Publisher: John Wiley & Sons ISBN: 0470514604 Category : Science Languages : en Pages : 348
Book Description
Prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. Also considers the implications of the basic and clinical research for humans.
Author: Urs Albrecht Publisher: Springer Science & Business Media ISBN: 1441912622 Category : Science Languages : en Pages : 306
Book Description
With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.
Author: Arthur T. Winfree Publisher: Macmillan + ORM ISBN: 1466813954 Category : Science Languages : en Pages : 341
Book Description
"A clock," writes Arthur T. Winfree, "is not much good if you can't pull out its stem and set it." Similarly, the most critical property of biological clocks--which rhythmically organize the processes of life--is their ability to reset on cue. This ability allows enables biological clocks to regain synchrony with a changing environment (as when we travel across time zones) or to maintain the alignment between certain physiological rhythms and the natural solar day. In The Timing of Biological Clocks, Winfree explores circadian rhythms. In reporting experiments on animals, plants, and single cells, he not only illustrates the principles that guide the resetting of biological clocks but reveals that each of these clocks has a vulnerable phase, a moment in each "turn of the dial" when a cueing stimulus of a particular intensity results in an abnormal, unpredictable resetting--perhaps even annihilating the clock's rhythm entirely. A singular feature of the author's exploration of these phenomena is his use of a range of colors to represent the passage of cyclic time. By this device, Winfree not only removes the purely arbitrary discontinuity of a conventional clock dial but makes reasoning about the real discontinuities of biological clocks transparently clear.
Author: Achim Kramer Publisher: Springer Science & Business Media ISBN: 3642259502 Category : Medical Languages : en Pages : 414
Book Description
This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
Author: Joseph S. Takahashi Publisher: Springer Science & Business Media ISBN: 9780306465048 Category : Medical Languages : en Pages : 820
Book Description
The nature of the circadian clocks is described at the molecular, cellular, tissue, and system levels of organization in diverse organisms. The central role of the circadian clock in the regulation of the sleep-wake cycle as well as seasonal rhythms and other cyclical processes is also discussed. The importance of the circadian clock system for human health, safety, performance, and productivity is also reviewed in this volume."--BOOK JACKET.
Author: Susie Vrobel Publisher: World Scientific ISBN: 9814295973 Category : Science Languages : en Pages : 312
Book Description
This book provides an interdisciplinary introduction to the notion of fractal time, starting from scratch with a philosophical and perceptual puzzle. How subjective duration varies, depending on the way we embed current content into contexts, is explained. The complexity of our temporal perspective depends on the number of nestings performed, i.e. on the number of contexts taken into account. This temporal contextualization is described against the background of the notion of fractal time. Our temporal interface, the Now, is portrayed as a fractal structure which arises from the distribution of content and contexts in two dimensions: the length and the depth of time. The leitmotif of the book is the notion of simultaneity, which determines the temporal structure of our interfaces. Recent research results are described which present and discuss a number of distorted temporal perspectives. It is suggested that dynamical diseases arise from unsuccessful nesting attempts, i.e. from failed contextualization. Successful nesting, by contrast, manifests itself in a "win-win handshake" between the observer-participant and his chosen context. The answer as to why a watched kettle never boils has repercussions in many a discipline. It would be of immense interest to anyone who works in the fields of cognitive and complexity sciences, psychology and the neurosciences, social medicine, philosophy and the arts.
Author: Timo Partonen
Author: Timo Partonen
Author: 
Author: Jay C. Dunlap
Author: Derek J. Chadwick
Author: Urs Albrecht
Author: Charles A. Czeisler
Author: Arthur T. Winfree
Author: Achim Kramer
Author: Joseph S. Takahashi
Author: Susie Vrobel