Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences PDF Download

Author: Pierre R. Bushel
Publisher: Frontiers Media SA
ISBN: 2889457664
Category :
Languages : en
Pages : 112

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Book Description
Toxicogenomics combines the use of toxicology and genomic sciences to elucidate chemical, toxic and environmental stressor effects on biological systems. Integrative toxicogenomics requires innovation in bioinformatics, statistics and systems toxicology and typically a combination of the utility of two of more of these disciplines to better understand molecular mechanisms involved in toxic responses. This Frontiers in Toxicogenomics Research Topic eBook focuses on integrative toxicogenomics more so at the late stage (analyzing each data set separately and then merging the results ) and brings together analyses that combine gene expression (microarray, TempO-Seq or RNA-Seq) with other data (biological assays, clinical chemistry, therapeutic categories or molecular pathways) or highlights data analytics that leverage bioinformatics and statistics. The eight articles illustrate the state-of-art in the field and the analysis of toxicogenomics data for a more comprehensive deduction of biological mechanisms and cellular functions associated with adverse outcomes from environmental exposures, chemicals and toxicants. However, it is clear that the field of integrative toxicogenomics needs considerably more attention paid to it in order to develop other clever ways of integrating the data for analysis.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309112982
Category : Science
Languages : en
Pages : 300

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Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Author: Sara Shostak
Publisher: Univ of California Press
ISBN: 0520275187
Category : Health & Fitness
Languages : en
Pages : 311

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Book Description
We rely on environmental health scientists to document the presence of chemicals where we live, work, and play and to provide an empirical basis for public policy. In the last decades of the 20th century, environmental health scientists began to shift their focus deep within the human body, and to the molecular level, in order to investigate gene-environment interactions. In Exposed Science, Sara Shostak analyzes the rise of gene-environment interaction in the environmental health sciences and examines its consequences for how we understand and seek to protect population health. Drawing on in-depth interviews and ethnographic observation, Shostak demonstrates that what we know – and what we don’t know – about the vulnerabilities of our bodies to environmental hazards is profoundly shaped by environmental health scientists’ efforts to address the structural vulnerabilities of their field. She then takes up the political effects of this research, both from the perspective of those who seek to establish genomic technologies as a new basis for environmental regulation, and from the perspective of environmental justice activists, who are concerned that that their efforts to redress the social, political, and economical inequalities that put people at risk of environmental exposure will be undermined by molecular explanations of environmental health and illness. Exposed Science thus offers critically important new ways of understanding and engaging with the emergence of gene-environment interaction as a focal concern of environmental health science, policy-making, and activism.

Author: Paul A. Schulte
Publisher: Academic Press
ISBN: 0323138578
Category : Medical
Languages : en
Pages : 609

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Book Description
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309120462
Category : Political Science
Languages : en
Pages : 422

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Book Description
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Author: Victor R. Preedy
Publisher: Springer
ISBN: 9789400776951
Category : Medical
Languages : en
Pages : 0

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Book Description
In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics and so on. The chapters are written by national or international experts and specialists.

Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 1439830096
Category : Medical
Languages : en
Pages : 312

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Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Author: Neelam Thakur
Publisher: CRC Press
ISBN: 1040144152
Category : Medical
Languages : en
Pages : 345

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Book Description
This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance. Additionally, it explores nanotechnology in radiation therapy, phototherapy modalities and bioengineered virus-like nanoparticles for diagnostics and therapeutics. The last section reviews the clinical applications and prospects, examining theranostic nanoparticles, the clinical translation of nanomedicine and the current limitations of cancer nanotherapy. It also addresses future directions in nanoparticle application, and examines the genotoxicity, immunotoxicity, cytotoxicity assessments, safety profiles, targeted drug delivery, and their role in viral oncogenesis. This book is a useful resource for researchers, clinicians and students in the fields of oncology and nanotechnology.

Author: Danny D. Reible
Publisher: Springer Science & Business Media
ISBN: 1461467268
Category : Technology & Engineering
Languages : en
Pages : 496

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Book Description
The purpose of this book is to help engineers and scientists better understand contaminated sediment sites and identify and design remedial approaches that are more efficient and effective. Contaminated sediment management is a difficult and costly exercise that is rarely addressed with easily identified and implemented remedies. It is hoped that this book can help identify and implement management approaches that provide an optimal, if not entirely satisfactory, solution to sediment contaminant problems.​

Author: Florian Markowetz
Publisher: Cambridge University Press
ISBN: 131638098X
Category : Science
Languages : en
Pages : 287

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Book Description
Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.