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Author: Dan Gusfield Publisher: Cambridge University Press ISBN: 1108386253 Category : Computers Languages : en Pages : 431
Book Description
Integer linear programming (ILP) is a versatile modeling and optimization technique that is increasingly used in non-traditional ways in biology, with the potential to transform biological computation. However, few biologists know about it. This how-to and why-do text introduces ILP through the lens of computational and systems biology. It uses in-depth examples from genomics, phylogenetics, RNA, protein folding, network analysis, cancer, ecology, co-evolution, DNA sequencing, sequence analysis, pedigree and sibling inference, haplotyping, and more, to establish the power of ILP. This book aims to teach the logic of modeling and solving problems with ILP, and to teach the practical 'work flow' involved in using ILP in biology. Written for a wide audience, with no biological or computational prerequisites, this book is appropriate for entry-level and advanced courses aimed at biological and computational students, and as a source for specialists. Numerous exercises and accompanying software (in Python and Perl) demonstrate the concepts.
Author: Saul I. Gass Publisher: Courier Corporation ISBN: 048643284X Category : Mathematics Languages : en Pages : 545
Book Description
Comprehensive, well-organized volume, suitable for undergraduates, covers theoretical, computational, and applied areas in linear programming. Expanded, updated edition; useful both as a text and as a reference book. 1995 edition.
Author: John W. Chinneck Publisher: Springer Science & Business Media ISBN: 0387749322 Category : Mathematics Languages : en Pages : 283
Book Description
Written by a world leader in the field and aimed at researchers in applied and engineering sciences, this brilliant text has as its main goal imparting an understanding of the methods so that practitioners can make immediate use of existing algorithms and software, and so that researchers can extend the state of the art and find new applications. It includes algorithms on seeking feasibility and analyzing infeasibility, as well as describing new and surprising applications.
Author: Jon Lee Publisher: Springer Science & Business Media ISBN: 1461419271 Category : Mathematics Languages : en Pages : 687
Book Description
Many engineering, operations, and scientific applications include a mixture of discrete and continuous decision variables and nonlinear relationships involving the decision variables that have a pronounced effect on the set of feasible and optimal solutions. Mixed-integer nonlinear programming (MINLP) problems combine the numerical difficulties of handling nonlinear functions with the challenge of optimizing in the context of nonconvex functions and discrete variables. MINLP is one of the most flexible modeling paradigms available for optimization; but because its scope is so broad, in the most general cases it is hopelessly intractable. Nonetheless, an expanding body of researchers and practitioners — including chemical engineers, operations researchers, industrial engineers, mechanical engineers, economists, statisticians, computer scientists, operations managers, and mathematical programmers — are interested in solving large-scale MINLP instances.
Author: Gerard Sierksma Publisher: CRC Press ISBN: 1498743129 Category : Business & Economics Languages : en Pages : 676
Book Description
Presenting a strong and clear relationship between theory and practice, Linear and Integer Optimization: Theory and Practice is divided into two main parts. The first covers the theory of linear and integer optimization, including both basic and advanced topics. Dantzig's simplex algorithm, duality, sensitivity analysis, integer optimization models
Author: Aidong Zhang Publisher: Cambridge University Press ISBN: 1139479032 Category : Computers Languages : en Pages : 283
Book Description
The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with the interactions of similar known proteins. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.
Author: Jeff Edmonds Publisher: Cambridge University Press ISBN: 1139471759 Category : Computers Languages : en Pages : 409
Book Description
This textbook, for second- or third-year students of computer science, presents insights, notations, and analogies to help them describe and think about algorithms like an expert, without grinding through lots of formal proof. Solutions to many problems are provided to let students check their progress, while class-tested PowerPoint slides are on the web for anyone running the course. By looking at both the big picture and easy step-by-step methods for developing algorithms, the author guides students around the common pitfalls. He stresses paradigms such as loop invariants and recursion to unify a huge range of algorithms into a few meta-algorithms. The book fosters a deeper understanding of how and why each algorithm works. These insights are presented in a careful and clear way, helping students to think abstractly and preparing them for creating their own innovative ways to solve problems.
Author: Tandy Warnow Publisher: Cambridge University Press ISBN: 1107184711 Category : Computers Languages : en Pages : 399
Book Description
This book presents the foundations of phylogeny estimation and technical material enabling researchers to develop improved computational methods.
Author: Dan Gusfield
Author: Dan Gusfield
Author: Dan Gusfield
Author: Saul I. Gass
Author: John W. Chinneck
Author: Jon Lee
Author: Gerard Sierksma
Author: Aidong Zhang
Author: L. Pachter
Author: Jeff Edmonds
Author: Tandy Warnow