Insulin-Like Growth Factors in Development, Cancers and Aging PDF Download

Author: Haim Werner
Publisher: MDPI
ISBN: 3036507701
Category : Science
Languages : en
Pages : 196

View

Book Description
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.

Author: Haim Werner
Publisher:
ISBN: 9783036507712
Category :
Languages : en
Pages : 196

View

Book Description
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners.

Author:
Publisher: Academic Press
ISBN: 0080922155
Category : Science
Languages : en
Pages : 766

View

Book Description
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. Longest running series published by Academic Press Contributions by leading international authorities

Author: Kerry S. Courneya
Publisher: Springer Science & Business Media
ISBN: 3642042317
Category : Medical
Languages : en
Pages : 389

View

Book Description
This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors are discussed, and behavior change strategies for increasing physical activity in cancer survivors are appraised. The final part of the book is devoted to special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.

Author: Derek LeRoith
Publisher: CRC Press
ISBN: 9780849357121
Category : Medical
Languages : en
Pages : 328

View

Book Description
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

Author: Derek LeRoith
Publisher: Springer Science & Business Media
ISBN: 146140598X
Category : Medical
Languages : en
Pages : 290

View

Book Description
The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 30

View

Book Description
A marked propensity for prostate cancer to arises in the peripheral prostate with aging. The Insulin-like Growth Factor-II (IGF-II) gene is an auto-paracrine growth stimulator that is an important positive modulator of cancer development. lGF-II typically demonstrates monoallelic, or imprinted, expression in adult tissues and indeed this pattern is maintained in the periurethral zone, a region where cancer development is rare. In addition, IGF-II loss of imprinting (LOl), as well as increased lGF-II expression, are common attributes of prostate cancer. It is our hypothesis to be tested that an age-dependent loss of lGF-II imprinting, resulting from age-dependent changes in DNA methylation, occurs specifically in the peripheral zone of the prostate and contributes to the increased risk for cancer development. To examine temporally when this loss of IGF-II imprinting occurs and the mechanisms underlying it we propose 3 Specific Aims: (1) To determine if IGF-II LOl in the peripheral prostate derives from stromal and/or epithelial cells; (2) To determine whether lGF-II LOl occurs as an age-dependent process in human prostate tissues that are uninvolved with cancer; and (3) To examine DNA methylation as a mechanism for any observed changes in the imprint status in prostate tissues. This proposal is significant and unique in testing whether regional epigenetic changes occur in histologically normal prostate tissues that are destined to become neoplastic. We expect to determine whether specific age-related, peripheral zone changes in methylation and imprinting occur in the general population and whether these changes are linked to prostate cancer development.

Author: Martin O. Savage
Publisher:
ISBN: 9780702020933
Category : Insulin-like growth factor-binding proteins
Languages : en
Pages : 9

View

Book Description
Examining growth hormone resistance, this text includes coverage of such topics as: growth hormone receptor signalling; metabolic actions of growth hormone - direct and indirect; and IGF bioactivity and its modification in growth hormone resistance in childhood.

Author: Derek LeRoith
Publisher:
ISBN:
Category :
Languages : en
Pages : 223

View

Book Description

Author: Jens O. L. Jørgensen
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805579926
Category : Science
Languages : en
Pages : 241

View

Book Description
It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.