Insights to Neuroimmune Biology PDF Download

Author: Istvan Berczi
Publisher: Elsevier
ISBN: 012801833X
Category : Science
Languages : en
Pages : 312

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Book Description
Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms. - Provides information on the importance and applicability of the field of neuroimmunology - Describes subjects that have shown significant recent developments - Introduces a whole new dimension to neuroimmunology by discussing Epigenetic Immunoregulation - Investigates the mechanisms and functions of the Neuroimmune Regulatory Supersystem - Promotes translational research in the field of neuroimmune biology - Covers challenges, such as dealing with problems of e.g., hypothalamic regulation of immune functions, interrelationships of stress and disease, epigenetic immunoregulation, neuroprotection, and neuroimmune regulation in pregnancy.

Author: Istvan Berczi
Publisher: Elsevier
ISBN: 0123846927
Category : Science
Languages : en
Pages : 285

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Book Description
New Insights to Neuroimmune Biology investigates the mechanisms that and functions of the Neuroimmune Regulatory Supersystem. Covering molecular regulation of cytokines in brain astrocytes, immunoregulation by the sympathetic nervous system, circadian regulation of immune reactions, antigen recognition by the CNS, the modulation of the immune response by head injury, neurogenic inflammation, the role of tachykinins in asthma and allergic disease, defence and defeat reactions, cytokines, behavior and affective disorders, increased activity of type 1 helper T cell functions after reward stimulation.This book has relevance to the entire scientific community in Biology, Medicine and Veterinary medicine as it discusses molecular, cellular, organic and systemic aspects as well as the physological, pathophysiological and behavioral mechnisms which are involved in Neuroimmiune Biology.

Author: Michal Schwartz
Publisher: Yale University Press
ISBN: 0300203470
Category : Medical
Languages : en
Pages : 316

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Book Description
Pathbreaking research offers new hope for treating brain diseases and injuries and for maintaining brain health even into old age In the past, the brain was considered an autonomous organ, self-contained and completely separate from the body's immune system. But over the past twenty years, neuroimmunologist Michal Schwartz, together with her research team, not only has overturned this misconception but has brought to light revolutionary new understandings of brain health and repair. In this book Schwartz describes her research journey, her experiments, and the triumphs and setbacks that led to the discovery of connections between immune system and brain. Michal Schwartz, with Anat London, also explains the significance of the findings for future treatments of brain disorders and injuries, spinal cord injuries, glaucoma, depression, and other conditions such as brain aging and Alzheimer's and Parkinson's diseases. Scientists, physicians, medical students, and all readers with an interest in brain function and its relationship to the immune system in health and disease will find this book a valuable resource. With general readers in mind, the authors provide a useful primer to explain scientific terms and concepts discussed in the book.

Author: Valentin A. Pavlov
Publisher: Frontiers Media SA
ISBN: 2889455335
Category :
Languages : en
Pages : 222

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Book Description
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.

Author: Allan Siegel
Publisher: Springer Science & Business Media
ISBN: 0387848517
Category : Medical
Languages : en
Pages : 437

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Book Description
For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter “Cytokines and the Blood–Brain Barrier” p- vides insight into interactions between the blood–brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter “Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines,” the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.

Author: Qing Yan
Publisher: Humana Press
ISBN: 9781627030700
Category : Medical
Languages : en
Pages : 0

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Book Description
Psychoneuroimmunology (PNI) has developed rapidly in the last four decades. As a multidisciplinary area, PNI may provide a scientific basis for mind-body relationships toward the development of personalized and systems medicine. In Psychoneuroimmunology:Methods and Protocols, expert researchers in the field detail methods and protocols geared toward the development of integrative and individualized therapeutics in multiple dimensions from drugs to behaviors. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Psychoneuroimmunology:Methods and Protocols aids scientists in continuing to study holistic views for the translation of psychoneuroimmunology into better preventive and personalized medical practice.

Author: Lee Arnold Green
Publisher: Christian Faith Publishing, Inc.
ISBN:
Category : Religion
Languages : en
Pages : 532

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Book Description
The Book of Affinitive Life: Part 1 in Conjunction: The Book of Life is mainly about life on Earth concerning the invited signals of love that create addictions and eventually transcend into affinitive life. It is commonly characterized in the world as a passion, hobby, or bond to someone or something; and it is practiced or lived by means of a habitual lifestyle or habit by virtue of signal responsiveness in response to behavior in interaction with whom or what affinitive life centers on. The surprisingly interesting spiritual fact about the love signal is that it lies beyond ordinary experiences and supernaturally transcends into an acquired spirit that is grafted into your natural spirit as an integral part, which is then potentially lived as affinitive life, and in turn, a passion, hobby, or bond to someone or something. Affinitive life as a passion, hobby, or bond is actually unknown to the world as such. That is because it is spirit-based and all spiritual lives are physically based. First Corinthians 2:14-15 says, "The natural man receiveth not the things of the Spirit of God: for they are foolishness unto him: neither can he know them, because they are spiritually discerned. But he that is spiritual judgeth all things, yet he himself is judged of no man." That means scientists could never use genetic engineering to find the true meaning of passions, hobbies, or bonding to someone or something as an affinitive life because it is foolishness to them. Genetic engineering is the direct manipulation of an organism's genome, which means its genes are used by biotechnology, also called genetic modification, which is genetic manipulation of the genes of an organism's genome. This book is the book of affinitive life, part 1, to the natural side of life and the book of life to the spirit side of life of invited signals of love. For that reason, the name of this book is The Book of Affinitive Life: Part 1 in Conjunction: The Book of Life. It is called The Book of Affinitive Life as it refers to and relates to the natural side of life first, and then to the same degree, it relates to the spirit side of life. Additionally, it characterizes the Book of Life, which no natural or ordinary man could write; there had to be a spiritual component. All affinitive lives are lived optionally as a habitual lifestyle or habit in natural life, in conjunction with natural life as an integral part.

Author: Vladimir V. Klimov
Publisher: Springer Nature
ISBN: 303104309X
Category : Medical
Languages : en
Pages : 317

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Book Description
Allergies are a significant health issue, yet few books exist on allergen tolerance of separation; here the author classifies allergen tolerance breakdown in specific types, according to the possibility that the autonomic breakdown of allergen tolerance in the unified airway depends on a deficit of pro-tolerogenic neurotransmitters at the local level. This paradigm, which explains the pathogenesis of allergic disorders, opens to new approaches to allergen-specific immunotherapy (AIT). While focusing on the new atopic disorders of the unified airway, such as local allergic rhinitis, "dual" allergic rhinitis, local allergic asthma, and local allergic conjunctivitis, the work combines clinical examples of allergic diseases and their treatment with their immunological background. The topics range from the specific immune-derived maintenance of allergen tolerance and the role of the neuroimmune network in allergic inflammation to conventional atopic diseases and more particular issues of local atopic disorders in the unified airway, oral tolerance, and its breakdown, and its translation in genitourinary aspects of allergic inflammation. Specific chapters are also devoted to allergen-specific immunotherapy (AIT) and anti-allergy treatments. Thought for upper graduate students, it will also be a valued resource for allergy practitioners, pulmonologists, ENT specialists, pediatricians, and translational researchers. Textbook of Allergen Tolerance includes classical didactic features such as abstracts, keywords, background notes, discussion points, and Q&A., as well as 20 audio files Text-to-Speech for the visually impaired, and 10 video to support the readers.

Author: Sana Loue
Publisher: Springer Nature
ISBN: 3031103300
Category : Psychology
Languages : en
Pages : 370

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Book Description
This book responds to the needs that arise at the intersection of people and animals, focusing on human-animal interaction, human-animal studies, the emotional work of caring for animals, and animal-assisted interventions and therapies. Unlike many works that focus primarily on issues at the micro level, such as animal-assisted interventions, this volume is unique in its focus on issues arising at the micro, macro, and mezzo levels, encompassing human-animal issues and interactions at the level of individuals and family, groups, institutions, and communities. Accordingly, this comprehensive guide addresses the need to better prepare practitioners to work in interdisciplinary environments, whether in the context of theory, research, practice, or advocacy. The authorship of the volume reflects the interdisciplinary foundations of veterinary social work, with contributions from social workers, psychologists, veterinarians, physicians, anthropologists, and bioethicists. The volume is divided into five parts that examine, respectively: the foundations (history and scope) of veterinary social work (Part I); the practice of veterinary social work with individuals, in the context of community programs, and in social work practice (Part II); veterinary social work and the veterinary setting, including veterinary well-being and conflict management (Part III); veterinary social work education (Part IV); and the future of veterinary social work (Part V). Importantly, the volume addresses not only practice issues in the veterinary, clinical, and community settings, but also examines ethical concerns in the clinical and research contexts and the implications of cultural and societal variations on the practice of veterinary social work. The Comprehensive Guide to Interdisciplinary Veterinary Social Work is the definitive resource for social workers and psychologists new to practice issues relating to animals, social work and psychology students at the graduate and undergraduate levels, veterinarians and veterinary students, hospital administrators (human hospitals), and veterinary hospital managers.

Author:
Publisher: Elsevier
ISBN: 0444535454
Category : Medical
Languages : en
Pages : 362

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Book Description
It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems.Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. - Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases - Includes analysis of the role of the brain in the adaptive responses to disease - Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases