Author: Rupa Marya
Publisher: Farrar, Straus and Giroux
ISBN: 0374602522
Category : Social Science
Languages : en
Pages : 496
Book Description
Raj Patel, the New York Times bestselling author of The Value of Nothing, teams up with physician, activist, and co-founder of the Do No Harm Coalition Rupa Marya to reveal the links between health and structural injustices--and to offer a new deep medicine that can heal our bodies and our world. The Covid pandemic and the shocking racial disparities in its impact. The surge in inflammatory illnesses such as gastrointestinal disorders and asthma. Mass uprisings around the world in response to systemic racism and violence. Rising numbers of climate refugees. Our bodies, societies, and planet are inflamed. Boldly original, Inflamed takes us on a medical tour through the human body—our digestive, endocrine, circulatory, respiratory, reproductive, immune, and nervous systems. Unlike a traditional anatomy book, this groundbreaking work illuminates the hidden relationships between our biological systems and the profound injustices of our political and economic systems. Inflammation is connected to the food we eat, the air we breathe, and the diversity of the microbes living inside us, which regulate everything from our brain’s development to our immune system’s functioning. It’s connected to the number of traumatic events we experienced as children and to the traumas endured by our ancestors. It’s connected not only to access to health care but to the very models of health that physicians practice. Raj Patel, the renowned political economist and New York Times bestselling author of The Value of Nothing, teams up with the physician Rupa Marya to offer a radical new cure: the deep medicine of decolonization. Decolonizing heals what has been divided, reestablishing our relationships with the Earth and one another. Combining the latest scientific research and scholarship on globalization with the stories of Marya’s work with patients in marginalized communities, activist passion, and the wisdom of Indigenous groups, Inflamed points the way toward a deep medicine that has the potential to heal not only our bodies, but the world.
Inflamed
Author: Rupa Marya
Publisher: Farrar, Straus and Giroux
ISBN: 0374602522
Category : Social Science
Languages : en
Pages : 496
Book Description
Raj Patel, the New York Times bestselling author of The Value of Nothing, teams up with physician, activist, and co-founder of the Do No Harm Coalition Rupa Marya to reveal the links between health and structural injustices--and to offer a new deep medicine that can heal our bodies and our world. The Covid pandemic and the shocking racial disparities in its impact. The surge in inflammatory illnesses such as gastrointestinal disorders and asthma. Mass uprisings around the world in response to systemic racism and violence. Rising numbers of climate refugees. Our bodies, societies, and planet are inflamed. Boldly original, Inflamed takes us on a medical tour through the human body—our digestive, endocrine, circulatory, respiratory, reproductive, immune, and nervous systems. Unlike a traditional anatomy book, this groundbreaking work illuminates the hidden relationships between our biological systems and the profound injustices of our political and economic systems. Inflammation is connected to the food we eat, the air we breathe, and the diversity of the microbes living inside us, which regulate everything from our brain’s development to our immune system’s functioning. It’s connected to the number of traumatic events we experienced as children and to the traumas endured by our ancestors. It’s connected not only to access to health care but to the very models of health that physicians practice. Raj Patel, the renowned political economist and New York Times bestselling author of The Value of Nothing, teams up with the physician Rupa Marya to offer a radical new cure: the deep medicine of decolonization. Decolonizing heals what has been divided, reestablishing our relationships with the Earth and one another. Combining the latest scientific research and scholarship on globalization with the stories of Marya’s work with patients in marginalized communities, activist passion, and the wisdom of Indigenous groups, Inflamed points the way toward a deep medicine that has the potential to heal not only our bodies, but the world.
Publisher: Farrar, Straus and Giroux
ISBN: 0374602522
Category : Social Science
Languages : en
Pages : 496
Book Description
Raj Patel, the New York Times bestselling author of The Value of Nothing, teams up with physician, activist, and co-founder of the Do No Harm Coalition Rupa Marya to reveal the links between health and structural injustices--and to offer a new deep medicine that can heal our bodies and our world. The Covid pandemic and the shocking racial disparities in its impact. The surge in inflammatory illnesses such as gastrointestinal disorders and asthma. Mass uprisings around the world in response to systemic racism and violence. Rising numbers of climate refugees. Our bodies, societies, and planet are inflamed. Boldly original, Inflamed takes us on a medical tour through the human body—our digestive, endocrine, circulatory, respiratory, reproductive, immune, and nervous systems. Unlike a traditional anatomy book, this groundbreaking work illuminates the hidden relationships between our biological systems and the profound injustices of our political and economic systems. Inflammation is connected to the food we eat, the air we breathe, and the diversity of the microbes living inside us, which regulate everything from our brain’s development to our immune system’s functioning. It’s connected to the number of traumatic events we experienced as children and to the traumas endured by our ancestors. It’s connected not only to access to health care but to the very models of health that physicians practice. Raj Patel, the renowned political economist and New York Times bestselling author of The Value of Nothing, teams up with the physician Rupa Marya to offer a radical new cure: the deep medicine of decolonization. Decolonizing heals what has been divided, reestablishing our relationships with the Earth and one another. Combining the latest scientific research and scholarship on globalization with the stories of Marya’s work with patients in marginalized communities, activist passion, and the wisdom of Indigenous groups, Inflamed points the way toward a deep medicine that has the potential to heal not only our bodies, but the world.
Inflamed
Author: Anne E. Belden
Publisher: Simon and Schuster
ISBN: 1642939374
Category : Social Science
Languages : en
Pages : 438
Book Description
The dramatic story of hundreds of senior citizens left in the path of a ferocious firestorm and what the quest for accountability reveals about the increasing risks to our most vulnerable population. “…a powerful work of investigative journalism about a particularly vulnerable segment of the population…. Alongside an engrossing account of the emergency as it unfolded in Sonoma County, Belden and Gullixson provide a definitive account of management’s woefully inadequate response at the two sister facilities. Their findings are a lesson to other care facilities —here’s what not to do.” —San Francisco Chronicle Just after midnight on October 9, 2017, as one of the nation’s deadliest and most destructive firestorms swept over California’s Wine Country, hundreds of elderly residents from two posh senior living facilities were caught in its path. The frailest were blind, in wheelchairs, or diagnosed with dementia, and their community quickly transformed from a palatial complex that pledged to care for them to one that threatened to entomb them. The rescue of the final 105 seniors left behind on an inflamed hillside depended not on employees, but strangers whose lives intersected in a riveting tale of terror and heroism. Headlines blamed caregivers for abandonment and neglect, but the truth proved far more complex—leading to a battle for accountability that stretched from the courtroom to the state legislature, and ultimately, to the ballot box. Inflamed: Abandonment, Heroism, and Outrage in Wine Country’s Deadliest Firestorm is the gripping and emotional narrative detailing what happened to these seniors, employees, and rescuers before, during, and after the Tubbs Fire decimated portions of Santa Rosa, including Oakmont Senior Living Villa Capri and part of Varenna at Fountaingrove. Anne Belden and Paul Gullixson are professional journalists and Sonoma County residents who spent three years recording each phase of the disaster in agonizing detail—from the botched evacuation and its excruciating aftermath to the investigations, lawsuits, and breakdowns that followed. They tell this harrowing story with a veracity and compassion only achieved by experienced reporters with local roots. Their narrative revisits the horrors of 2017 but also asks the reader to look to the future and consider how their community’s most vulnerable will fare as ten thousand Baby Boomers retire each day, the for-profit assisted living industry rapidly expands, and the climate becomes more volatile. If this travesty can happen at high-end senior living complexes, it can happen anywhere.
Publisher: Simon and Schuster
ISBN: 1642939374
Category : Social Science
Languages : en
Pages : 438
Book Description
The dramatic story of hundreds of senior citizens left in the path of a ferocious firestorm and what the quest for accountability reveals about the increasing risks to our most vulnerable population. “…a powerful work of investigative journalism about a particularly vulnerable segment of the population…. Alongside an engrossing account of the emergency as it unfolded in Sonoma County, Belden and Gullixson provide a definitive account of management’s woefully inadequate response at the two sister facilities. Their findings are a lesson to other care facilities —here’s what not to do.” —San Francisco Chronicle Just after midnight on October 9, 2017, as one of the nation’s deadliest and most destructive firestorms swept over California’s Wine Country, hundreds of elderly residents from two posh senior living facilities were caught in its path. The frailest were blind, in wheelchairs, or diagnosed with dementia, and their community quickly transformed from a palatial complex that pledged to care for them to one that threatened to entomb them. The rescue of the final 105 seniors left behind on an inflamed hillside depended not on employees, but strangers whose lives intersected in a riveting tale of terror and heroism. Headlines blamed caregivers for abandonment and neglect, but the truth proved far more complex—leading to a battle for accountability that stretched from the courtroom to the state legislature, and ultimately, to the ballot box. Inflamed: Abandonment, Heroism, and Outrage in Wine Country’s Deadliest Firestorm is the gripping and emotional narrative detailing what happened to these seniors, employees, and rescuers before, during, and after the Tubbs Fire decimated portions of Santa Rosa, including Oakmont Senior Living Villa Capri and part of Varenna at Fountaingrove. Anne Belden and Paul Gullixson are professional journalists and Sonoma County residents who spent three years recording each phase of the disaster in agonizing detail—from the botched evacuation and its excruciating aftermath to the investigations, lawsuits, and breakdowns that followed. They tell this harrowing story with a veracity and compassion only achieved by experienced reporters with local roots. Their narrative revisits the horrors of 2017 but also asks the reader to look to the future and consider how their community’s most vulnerable will fare as ten thousand Baby Boomers retire each day, the for-profit assisted living industry rapidly expands, and the climate becomes more volatile. If this travesty can happen at high-end senior living complexes, it can happen anywhere.
The Inflamed Mind
Author: Edward Bullmore
Publisher: Macmillan + ORM
ISBN: 1250318157
Category : Psychology
Languages : en
Pages : 239
Book Description
As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge professor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.
Publisher: Macmillan + ORM
ISBN: 1250318157
Category : Psychology
Languages : en
Pages : 239
Book Description
As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge professor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.
Brain Inflamed
Author: Kenneth Bock, MD
Publisher: HarperCollins
ISBN: 0062970895
Category : Health & Fitness
Languages : en
Pages : 304
Book Description
From renowned integrative physician Kenneth Bock, M.D., comes a groundbreaking approach to understanding adolescent and teen mental health disorders. Over the past decade, the number of 12- to 17-year-olds suffering from mental health disorders has more than doubled. While adolescents and teens are notorious for mood swings and rebellion, parents today are navigating new terrain as their children are increasingly at risk of struggling with a mental health issue. But the question remains: What is causing this epidemic of illness? In Brain Inflamed, acclaimed integrative doctor Dr. Kenneth Bock shares a revolutionary new view of adolescent and teen mental health—one that suggests many of the mental disorders most common among this population (including depression, anxiety, and OCD) may share the same underlying mechanism: systemic inflammation. In this groundbreaking work, Dr. Bock explains the essential role of the immune system and the microbiome in mental health, detailing the ways in which imbalances in these systems—such as autoimmune conditions, thyroid disorders, or leaky gut syndrome—can generate neurological inflammation. While most conventional doctors assume that teens’ psychological struggles can be resolved only with therapy and psychotropic drugs, Dr. Bock’s approach considers the whole-body health of his patients. In his integrative evaluations, he often uncovers triggers such as gluten sensitivity, adrenal dysfunction, Lyme disease, and post-strep infections—all of which create imbalances in the body that can generate psychological symptoms. Filled with incredible stories from Dr. Bock’s more than thirty years as a practicing physician, Brain Inflamed explains the biological underpinnings of many common mental health issues, and empowers the parents and family members of struggling teens with practical advice—and perhaps most importantly, hope for a brighter future.
Publisher: HarperCollins
ISBN: 0062970895
Category : Health & Fitness
Languages : en
Pages : 304
Book Description
From renowned integrative physician Kenneth Bock, M.D., comes a groundbreaking approach to understanding adolescent and teen mental health disorders. Over the past decade, the number of 12- to 17-year-olds suffering from mental health disorders has more than doubled. While adolescents and teens are notorious for mood swings and rebellion, parents today are navigating new terrain as their children are increasingly at risk of struggling with a mental health issue. But the question remains: What is causing this epidemic of illness? In Brain Inflamed, acclaimed integrative doctor Dr. Kenneth Bock shares a revolutionary new view of adolescent and teen mental health—one that suggests many of the mental disorders most common among this population (including depression, anxiety, and OCD) may share the same underlying mechanism: systemic inflammation. In this groundbreaking work, Dr. Bock explains the essential role of the immune system and the microbiome in mental health, detailing the ways in which imbalances in these systems—such as autoimmune conditions, thyroid disorders, or leaky gut syndrome—can generate neurological inflammation. While most conventional doctors assume that teens’ psychological struggles can be resolved only with therapy and psychotropic drugs, Dr. Bock’s approach considers the whole-body health of his patients. In his integrative evaluations, he often uncovers triggers such as gluten sensitivity, adrenal dysfunction, Lyme disease, and post-strep infections—all of which create imbalances in the body that can generate psychological symptoms. Filled with incredible stories from Dr. Bock’s more than thirty years as a practicing physician, Brain Inflamed explains the biological underpinnings of many common mental health issues, and empowers the parents and family members of struggling teens with practical advice—and perhaps most importantly, hope for a brighter future.
Inflamed
Author: Shelly Malone
Publisher: Agustin Publishing
ISBN: 9780692704400
Category :
Languages : en
Pages :
Book Description
Chosen by SELF Magazine as one of "7 Fascinating And Illuminating Books That Will Totally Open Your Eyes About Your Health" Both absorbing and revelatory, INFLAMED isn't just a story of healing (of an inflammatory, autoimmune condition). It's a crystal clear guide that cuts through the confusion and contradiction, offering an anti-inflammatory roadmap to reduce pain, calm chronic symptoms, and light a path to glowing, vibrant health. Whether your personal health simply feels slightly off, or you're experiencing a serious chronic illness, conventional care alone may not be getting you the results you want. Are you experiencing issues like fatigue, poor mood, resistant weight loss, aching joints, digestive upset or skin problems? INFLAMED is your concise guide to changing your life by reducing inflammation. A refreshing voice for readers who appreciate Western medicine, but who are searching for treatments that solve the root cause of their conditions - not just address them with a quick, pharmacological fix - Shelly Malone is the discerning expert chronic sufferers have been waiting for. Inside, readers will find: Exactly what inflammation means and how it manifests (including pain, allergies, infertility, depression, obesity and autoimmune conditions) The complete story on gluten, dairy and other food sensitivities The role your genes do and don't play in disease What your digestive tract is trying to tell you Why it's time to trade the calorie and fat gram counting for brand new eating principles Where inflammatory toxins hide (in your food, in your home and on your body) The synergistic connection between stress, sleep and hormones How your past medical history could be contributing to your poor health INFLAMED closes with a customizable, 25-step action plan the meets you where you are and provides over 20 guides from meal/snack ideas to product label guides to "lesser evils," a chart of delicious (and realistic) food substitutions. Lifestyle change can be intimidating. Learn how to get started with small, specific action steps for consistent progress - and better health. Find a reason - and a way - to live a healthy, vibrant life. www.inflamedbook.com
Publisher: Agustin Publishing
ISBN: 9780692704400
Category :
Languages : en
Pages :
Book Description
Chosen by SELF Magazine as one of "7 Fascinating And Illuminating Books That Will Totally Open Your Eyes About Your Health" Both absorbing and revelatory, INFLAMED isn't just a story of healing (of an inflammatory, autoimmune condition). It's a crystal clear guide that cuts through the confusion and contradiction, offering an anti-inflammatory roadmap to reduce pain, calm chronic symptoms, and light a path to glowing, vibrant health. Whether your personal health simply feels slightly off, or you're experiencing a serious chronic illness, conventional care alone may not be getting you the results you want. Are you experiencing issues like fatigue, poor mood, resistant weight loss, aching joints, digestive upset or skin problems? INFLAMED is your concise guide to changing your life by reducing inflammation. A refreshing voice for readers who appreciate Western medicine, but who are searching for treatments that solve the root cause of their conditions - not just address them with a quick, pharmacological fix - Shelly Malone is the discerning expert chronic sufferers have been waiting for. Inside, readers will find: Exactly what inflammation means and how it manifests (including pain, allergies, infertility, depression, obesity and autoimmune conditions) The complete story on gluten, dairy and other food sensitivities The role your genes do and don't play in disease What your digestive tract is trying to tell you Why it's time to trade the calorie and fat gram counting for brand new eating principles Where inflammatory toxins hide (in your food, in your home and on your body) The synergistic connection between stress, sleep and hormones How your past medical history could be contributing to your poor health INFLAMED closes with a customizable, 25-step action plan the meets you where you are and provides over 20 guides from meal/snack ideas to product label guides to "lesser evils," a chart of delicious (and realistic) food substitutions. Lifestyle change can be intimidating. Learn how to get started with small, specific action steps for consistent progress - and better health. Find a reason - and a way - to live a healthy, vibrant life. www.inflamedbook.com
The Value of Nothing
Author: Raj Patel
Publisher: Macmillan + ORM
ISBN: 1429982624
Category : Political Science
Languages : en
Pages : 24
Book Description
"A deeply though-provoking book about the dramatic changes we must make to save the planet from financial madness."--Naomi Klein, author of The Shock Doctrine Opening with Oscar Wilde's observation that "nowadays people know the price of everything and the value of nothing," Patel shows how our faith in prices as a way of valuing the world is misplaced. He reveals the hidden ecological and social costs of a hamburger (as much as $200), and asks how we came to have markets in the first place. Both the corporate capture of government and our current financial crisis, Patel argues, are a result of our democratically bankrupt political system. If part one asks how we can rebalance society and limit markets, part two answers by showing how social organizations, in America and around the globe, are finding new ways to describe the world's worth. If we don't want the market to price every aspect of our lives, we need to learn how such organizations have discovered democratic ways in which people, and not simply governments, can play a crucial role in deciding how we might share our world and its resources in common. This short, timely and inspiring book reveals that our current crisis is not simply the result of too much of the wrong kind of economics. While we need to rethink our economic model, Patel argues that the larger failure beneath the food, climate and economic crises is a political one. If economics is about choices, Patel writes, it isn't often said who gets to make them. The Value of Nothing offers a fresh and accessible way to think about economics and the choices we will all need to make in order to create a sustainable economy and society.
Publisher: Macmillan + ORM
ISBN: 1429982624
Category : Political Science
Languages : en
Pages : 24
Book Description
"A deeply though-provoking book about the dramatic changes we must make to save the planet from financial madness."--Naomi Klein, author of The Shock Doctrine Opening with Oscar Wilde's observation that "nowadays people know the price of everything and the value of nothing," Patel shows how our faith in prices as a way of valuing the world is misplaced. He reveals the hidden ecological and social costs of a hamburger (as much as $200), and asks how we came to have markets in the first place. Both the corporate capture of government and our current financial crisis, Patel argues, are a result of our democratically bankrupt political system. If part one asks how we can rebalance society and limit markets, part two answers by showing how social organizations, in America and around the globe, are finding new ways to describe the world's worth. If we don't want the market to price every aspect of our lives, we need to learn how such organizations have discovered democratic ways in which people, and not simply governments, can play a crucial role in deciding how we might share our world and its resources in common. This short, timely and inspiring book reveals that our current crisis is not simply the result of too much of the wrong kind of economics. While we need to rethink our economic model, Patel argues that the larger failure beneath the food, climate and economic crises is a political one. If economics is about choices, Patel writes, it isn't often said who gets to make them. The Value of Nothing offers a fresh and accessible way to think about economics and the choices we will all need to make in order to create a sustainable economy and society.
Inflamed Invisible
Author: David Toop
Publisher: MIT Press
ISBN: 1912685248
Category : Music
Languages : en
Pages : 304
Book Description
A rich collection of essays tracing the relationship between art and sound. In the 1970s David Toop became preoccupied with the possibility that music was no longer bounded by formalities of audience: the clapping, the booing, the short attention span, the demand for instant gratification. Considering sound and listening as foundational practices in themselves leads music into a thrilling new territory: stretched time, wilderness, video monitors, singing sculptures, weather, meditations, vibration and the interior resonance of objects, interspecies communications, instructional texts, silent actions, and performance art. Toop sought to document the originality and unfamiliarity of this work from his perspective as a practitioner and writer. The challenge was to do so without being drawn back into the domain of music while still acknowledging the vitality and hybridity of twentieth-century musics as they moved toward art galleries, museums, and site-specificity. Toop focused on practitioners, whose stories are as compelling as the theoretical and abstract implications of their works. Inflamed Invisible collects more than four decades of David Toop's essays, reviews, interviews, and experimental texts, drawing us into the company of artists and their concerns, not forgetting the quieter, unsung voices. The volume is an offering, an exploration of strata of sound that are the crossing points of sensory, intellectual, and philosophical preoccupations, layers through which objects, thoughts and air itself come alive as the inflamed invisible.
Publisher: MIT Press
ISBN: 1912685248
Category : Music
Languages : en
Pages : 304
Book Description
A rich collection of essays tracing the relationship between art and sound. In the 1970s David Toop became preoccupied with the possibility that music was no longer bounded by formalities of audience: the clapping, the booing, the short attention span, the demand for instant gratification. Considering sound and listening as foundational practices in themselves leads music into a thrilling new territory: stretched time, wilderness, video monitors, singing sculptures, weather, meditations, vibration and the interior resonance of objects, interspecies communications, instructional texts, silent actions, and performance art. Toop sought to document the originality and unfamiliarity of this work from his perspective as a practitioner and writer. The challenge was to do so without being drawn back into the domain of music while still acknowledging the vitality and hybridity of twentieth-century musics as they moved toward art galleries, museums, and site-specificity. Toop focused on practitioners, whose stories are as compelling as the theoretical and abstract implications of their works. Inflamed Invisible collects more than four decades of David Toop's essays, reviews, interviews, and experimental texts, drawing us into the company of artists and their concerns, not forgetting the quieter, unsung voices. The volume is an offering, an exploration of strata of sound that are the crossing points of sensory, intellectual, and philosophical preoccupations, layers through which objects, thoughts and air itself come alive as the inflamed invisible.
Inflammation and the Microcirculation
Author: D. Neil Granger
Publisher: Morgan & Claypool Publishers
ISBN: 1615041656
Category : Medical
Languages : en
Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Publisher: Morgan & Claypool Publishers
ISBN: 1615041656
Category : Medical
Languages : en
Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
The Inflamed Feeling
Author: Mats Lekander
Publisher: Oxford University Press
ISBN: 0198863446
Category : Medical
Languages : en
Pages : 265
Book Description
What do feeling sick and being afraid of strangers have in common? The answer is that these feelings represent a behavioural drive which evolved in our ancestors to combat the most dangerous threat to survival: infection. Behaviour and emotions play pivotal roles in the struggle for good health. When your body is telling your brain that you are sick, you are experiencing survival strategies that developed years ago. Listening to these feelings will allow you to save energy that can be used for recuperation and recovery. Urges of staying still, noticing pain, feeling sorry for yourself, and focusing inward are bodily messages that benefit immune defence. For our forefathers, in whom these strategies evolved, it wasn't enough to change behaviour once sick. Defensive behaviours to be able to avoid infection in the first place were also needed. Thus, tools for detecting illness in others evolved. This is why superficial signs of ill-health, or maybe even the prejudicial idea of a person with a foreign bacterial culture, can cause anxiety and avoidance. Not surprisingly, having a too high or too low sensitivity to inner or outer disease signals is connected to mental as well as somatic disorders. In this book, Mats Lekander explains the science behind perceived health, using Barbie dolls, visual illusions, personal experiences, placebo, hypochondriacs and historical anecdotes. Placed against a back-drop of the latest neuroscience and psychoneuroimmunology he explains why you feel healthy or sick. He describes when he poisoned himself at work and enjoyed it, and why white blood cells and inflammation are key players when our brains trys to guess what is going in our inner worlds. The result is an absorbing and eye-opening book, one that seems so relevant in the current times.
Publisher: Oxford University Press
ISBN: 0198863446
Category : Medical
Languages : en
Pages : 265
Book Description
What do feeling sick and being afraid of strangers have in common? The answer is that these feelings represent a behavioural drive which evolved in our ancestors to combat the most dangerous threat to survival: infection. Behaviour and emotions play pivotal roles in the struggle for good health. When your body is telling your brain that you are sick, you are experiencing survival strategies that developed years ago. Listening to these feelings will allow you to save energy that can be used for recuperation and recovery. Urges of staying still, noticing pain, feeling sorry for yourself, and focusing inward are bodily messages that benefit immune defence. For our forefathers, in whom these strategies evolved, it wasn't enough to change behaviour once sick. Defensive behaviours to be able to avoid infection in the first place were also needed. Thus, tools for detecting illness in others evolved. This is why superficial signs of ill-health, or maybe even the prejudicial idea of a person with a foreign bacterial culture, can cause anxiety and avoidance. Not surprisingly, having a too high or too low sensitivity to inner or outer disease signals is connected to mental as well as somatic disorders. In this book, Mats Lekander explains the science behind perceived health, using Barbie dolls, visual illusions, personal experiences, placebo, hypochondriacs and historical anecdotes. Placed against a back-drop of the latest neuroscience and psychoneuroimmunology he explains why you feel healthy or sick. He describes when he poisoned himself at work and enjoyed it, and why white blood cells and inflammation are key players when our brains trys to guess what is going in our inner worlds. The result is an absorbing and eye-opening book, one that seems so relevant in the current times.
Fundamentals of Inflammation
Author: Charles N. Serhan
Publisher: Cambridge University Press
ISBN: 1139936670
Category : Science
Languages : en
Pages : 489
Book Description
The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
Publisher: Cambridge University Press
ISBN: 1139936670
Category : Science
Languages : en
Pages : 489
Book Description
The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.