Immunotherapeutic Biologic Agents to Treat Autoinflammatory Diseases PDF Download

Author: Barbara E. Ostrov
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :

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Book Description
In recent years, innovative treatment for patients with autoimmune and autoinflammatory diseases has advanced in concert with our increased understanding of molecular and clinical immunology. Deeper understanding of autoimmunity has allowed for the development of cutting-edge biologic drugs for patients with relatively common autoimmune diseases. During this same period, knowledge regarding the molecular bases of autoinflammatory genetic diseases has also greatly expanded. Biologic immunotherapeutic agents developed for autoimmune diseases that primarily target cytokines that are also dysregulated in the uncommon autoinflammatory diseases are the focus of this article. In the following pages, selected genetic autoinflammatory diseases and key immunotherapeutic treatment approaches are addressed. The current understanding of these diseases and mechanisms by which therapeutic agents may benefit patients are reviewed. Indications, risks, and additional considerations for the use of these agents in treatment of autoinflammatory disorders are addressed as well.

Author: Vibeke Strand
Publisher: CRC Press
ISBN: 1482273535
Category : Medical
Languages : en
Pages : 341

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Book Description
Provides a detailed survey of therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit.

Author: Krassimir Metodiev
Publisher: BoD – Books on Demand
ISBN: 9535131052
Category : Medical
Languages : en
Pages : 416

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Book Description
This is another attempt of InTechOpen to continue the dissemination of international knowledge and experience in the field of immunology. The present book includes a number of modern concepts of specialists and experts in the field of immunotherapy, covering the major topics and analyzing the history, current stage, and future ideas of application of modern immunomodulation. It is always a benefit, but also a compliment, to gather a team of internationally distinguished authors and to motivate them to reveal their expertise for the benefit of medical science and health practice. On behalf of all readers, immunologists, immunogeneticists, biologists, oncologists, microbiologists, virologists, hematologists, chemotherapists, health-care experts, as well as students and medical specialists, also on my personal behalf, I would like to extend my gratitude and highest appreciation to InTechOpen for giving me the unique chance to be the editor of this exclusive book.

Author: Sujata P. Sawarkar
Publisher: Springer Nature
ISBN: 9811590389
Category : Medical
Languages : en
Pages : 267

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Book Description
This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.

Author: Patrick Kimuyu
Publisher: GRIN Verlag
ISBN: 3668588511
Category : Medical
Languages : en
Pages : 14

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Book Description
Research Paper (postgraduate) from the year 2017 in the subject Medicine - Epidemiology, grade: 1.8, Egerton University, language: English, abstract: Immunotherapy approach seems to have gained a widespread application in the treatment of diseases, unlike in the past two decades when it was not considered as a significant treatment option. However, this treatment option dates back to the nineteenth century in which surgeons discovered the correlation between surgery and microbial infections, especially in post-surgery patients. For instance, William Coley, a renowned New York surgeon applied immunotherapy technique on cancer patients. This was after his realization that, some bacterial infections to post-surgery cancer patients helped to manage the disease. Coley received posthumous fame after researchers identified the beneficial bacteria as Coley toxins. Despite the success realized in the treatment of the disease, it was abandoned after new treatment techniques were discovered. Since then, immunotherapy received little attention from healthcare professionals and researchers until recently when it was found to be significant in treating most of the challenging diseases such as cancer, autoimmune diseases as well as infectious diseases.

Author: Paula Trahan Rieger
Publisher: Jones & Bartlett Publishers
ISBN:
Category : Medical
Languages : en
Pages : 360

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Book Description
Rieger (U. of Texas M.D. Anderson Cancer Center) synthesizes knowledge about this rapidly expanding field to help other nurses understand its biological basis and clinical indications. Targeted at oncology nurses, the text will also be of interest in other specialties using biological agents to treat conditions such as hepatitis, autoimmune diseases, and multiple sclerosis. New to this edition are chapters on the retinoids, vaccines, gene therapy, the management of anorexia as a toxic effect, and patients' perspectives on participation in clinical trials. Other new information includes recent data on the immune system, emerging strategies in molecular medicine, clinical "pearls" or tips that summarize key points, and lists of useful Web sites and other resources. Annotation copyrighted by Book News, Inc., Portland, OR

Author: Kazuwa Nakao
Publisher: Springer
ISBN: 4431556516
Category : Science
Languages : en
Pages : 330

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Book Description
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309180686
Category : Medical
Languages : en
Pages : 102

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Book Description
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Author: Fionula M. Brennan
Publisher: Landes Bioscience
ISBN:
Category : Autoimmune diseases
Languages : en
Pages : 286

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Book Description
A review of the field of cytokines in autoimmunity written by 22 researchers suggesting diverse applications, and building on the successes of recent rheumatoid arthritis clinical trials. The contributors present and review findings on arthritis, diabetes, multiple sclerosis, thyroid disease, Sjogren's syndrome, Lupus, scleroderma, and psoriasis. The final sections concentrate on laboratory and clinical concerns working with "knockout" mice, transgenic mice, and cytokine therapy. Distributed by Chapman and Hall. CiP shows the title as Role of cytokines..... Annotation copyright by Book News, Inc., Portland, OR

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309225493
Category : Medical
Languages : en
Pages : 432

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Book Description
The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.