Author: Maxim Chacko-Joseph CheeranPublisher:
ISBN:
Category :
Languages : en
Pages : 546
Book Description
Host Defense Mechanisms Against Human Cytomegalovirus Brain Infection
Author: Maxim Chacko-Joseph CheeranPublisher:
ISBN:
Category :
Languages : en
Pages : 546
Book Description
The Brain and Host Defense
Author: Publisher: Elsevier
ISBN: 0444535454
Category : Medical
Languages : en
Pages : 362
Book Description
It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems.Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. - Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases - Includes analysis of the role of the brain in the adaptive responses to disease - Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases
Human Cytomegalovirus
Author: Thomas E. ShenkPublisher: Springer Science & Business Media
ISBN: 3540773495
Category : Medical
Languages : en
Pages : 477
Book Description
This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
Human Herpesviruses
Author: Ann ArvinPublisher: Cambridge University Press
ISBN: 1139461648
Category : Medical
Languages : en
Pages : 1325
Book Description
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Chimpanzees in Biomedical and Behavioral Research
Author: National Research CouncilPublisher: National Academies Press
ISBN: 0309220424
Category : Science
Languages : en
Pages : 200
Book Description
For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Clinical Approach to Infection in the Compromised Host
Author: Robert H. RubinPublisher: Springer Science & Business Media
ISBN: 0306466937
Category : Medical
Languages : en
Pages : 748
Book Description
At the beginning of the new millennium, it is opportune to raveling of the molecular pathways of impaired host - review what has been accomplished in the field of infec- fense mechanisms and the characterization of the genetic tious diseases during the last decades of the previous mutations involved, with the prospect of novel strategies century. The paradigm of the immunocompromised host for therapeutic interventions and possible corrective gene has taught much about the pathophysiology of infectious therapy. In this foreword, I will take a helicopter view of diseases, particularly with regard to immunological as- the various aspects of host defense mechanisms with pects of host defense. In the beginning, Robert Good special emphasis on genetic factors, because of their re- called immunodeficiency syndromes "experiments of na- vance for the course and outcome of infections. ture." In the 1960s and subsequent decades, the clinical During life, there exist phases of age-related c- and immunological aspects of immune deficiencies were promised immune functions. After birth there is a phys- studied and adequate treatment attempted. A reflection of logical immune deficiency because the production of an- these developments were the three successful meetings on bodies commences slowly upon contact of the neonate these topics in Veldhoven, The Netherlands (1980), Stir- with microorganisms and upon vaccination.
Pathology and Pathogenesis of Human Viral Disease
Author: John E. CraigheadPublisher: Academic Press
ISBN: 0080538487
Category : Medical
Languages : en
Pages : 466
Book Description
Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection. Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians. - Provides a comprehensive, worldwide perspective of viral disease pathology - Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology - Addresses topics from the perspective of the clinical pathologist - Illustrates unique, viral induced pathological lesions - Considers common and uncommon complications of infection
Vascular Responses to Pathogens
Author: Felicity N.E. GavinsPublisher: Academic Press
ISBN: 0128013257
Category : Medical
Languages : en
Pages : 254
Book Description
Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease. - Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature - Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field - Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature - Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs
The Immune Response
Author: Tak W. MakPublisher: Academic Press
ISBN: 0080534481
Category : Medical
Languages : en
Pages : 1217
Book Description
The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail
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