Homogeneous Palladium Catalyzed Cyclizations and Reductions PDF Download

Author: Rebecca Braslau
Publisher:
ISBN:
Category :
Languages : en
Pages : 602

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Author: Montserrat Diéguez
Publisher: John Wiley & Sons
ISBN: 3527804072
Category : Technology & Engineering
Languages : en
Pages : 431

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An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

Author: Lonneke Jacoba Verhoeven
Publisher: Cuvillier Verlag
ISBN: 9783897129573
Category :
Languages : en
Pages : 136

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Author: P. Henry
Publisher: Springer
ISBN: 9789400994478
Category : Science
Languages : en
Pages : 435

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The field of organometallic chemistry has emerged over the last twenty-five years or so to become one of the most important areas of chemistry, and there are no signs of abatement in the intense current interest in the subject, particularly in terms of its proven and potential application in catalytic reactions involving hydrocarbons. The development of the organometallic/ catalysis area has resulted in no small way from many contributions from researchers investigating palladium systems. Even to the well-initiated, there seems a bewildering and diverse variety of organic reactions that are promoted by palladium(II) salts and complexes. Such homogeneous reactions include oxidative and nonoxidative coupling of substrates such as olefins, dienes, acetylenes, and aromatics; and various isomerization, disproportionation, hydrogenation, dehydrogenation, car bonylation and decarbonylation reactions, as well as reactions involving formation of bonds between carbon and halogen, nitrogen, sulfur, and silicon. The books by Peter M. Maitlis - The Organic Chemistry of Palladium, Volumes I, II, Academic Press, 1971 - serve to classify and identify the wide variety of reactions, and access to the vast literature is available through these volumes and more recent reviews, including those of J. Tsuji [Accounts Chem. Res. , 6, 8 (1973); Adv. in Organometal. , 17, 141 (1979)], R. F. Heck [Adv. in Catat. , 26, 323 (1977)], and ones by Henry [Accounts Chem. Res. , 6, 16 (1973); Adv. in Organometal. , 13, 363 (1975)]. F. R. Hartley's book - The Chemistry of Platinum and Palladium, App!. Sci. Pub!.

Author: Ei-ichi Negishi
Publisher: John Wiley & Sons
ISBN: 0471473812
Category : Science
Languages : en
Pages : 1657

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Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.

Author: Robertus J. M. Klein Gebbink
Publisher: John Wiley & Sons
ISBN: 3527699104
Category : Technology & Engineering
Languages : en
Pages : 709

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An expert overview of current research, applications, and economic and environmental advantages The study and development of new homogeneous catalysts based on first-row metals (Mn, Fe, Co, Ni, and Cu) has grown significantly due to the economic and environmental advantages that non-noble metals present. Base metals offer reduced cost, greater supply, and lower toxicity levels than noble metals?enabling greater opportunity for scientific investigation and increased development of practical applications. Non-Noble Metal Catalysis provides an authoritative survey of the field, from fundamental concepts and computational methods to industrial applications and reaction classes. Recognized experts in organometallic chemistry and homogeneous catalysis, the authors present a comprehensive overview of the conceptual and practical aspects of non-noble metal catalysts. Examination of topics including non-innocent ligands, proton-coupled electron transfer, and multi-nuclear complexes provide essential background information, while areas such as kinetic lability and lifetimes of intermediates reflect current research and shifting trends in the field. This timely book demonstrates the efficacy of base metal catalysts in the pharmaceutical, fine-chemical, and agrochemical industries, addressing both environmental and economic concerns. Providing essential conceptual and practical exploration, this valuable resource: -Illustrates how unravelling new reactivity patterns can lead to new catalysts and new applications -Highlights the multiple advantages of using non-noble metals in homogenous catalysis -Demonstrates how the availability of non-noble metal catalysis reduces costs and leads to immense savings for the chemical industry -Reveals how non-noble metal catalysis are more sustainable than noble metals such as palladium or platinum Non-Noble Metal Catalysis: Molecular Approaches and Reactions is an indispensable source of up-to-date information for catalytic chemists, organic chemists, industrial chemists, organometallic chemists, and those seeking to broaden their knowledge of catalytic chemistry.

Author: Árpád Molnár
Publisher: John Wiley & Sons
ISBN: 3527648305
Category : Science
Languages : en
Pages : 531

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This handbook and ready reference brings together all significant issues of practical importance in selected topics discussing recent significant achievements for interested readers in one single volume. While covering homogeneous and heterogeneous catalysis, the text is unique in focusing on such important aspects as using different reaction media, microwave techniques or catalyst recycling. It also provides a comprehensive treatment of key issues of modern-day coupling reactions having emerged and matured in recent years and emphasizes those topics that show potential for future development, such as continuous flow systems, water as a reaction medium, and catalyst immobilization, among others. With its inclusion of large-scale applications in the pharmaceutical industry, this will equally be of great interest to industrial chemists. From the contents * Palladium-Catalyzed Cross-Coupling Reactions - A General Introduction * High-turnover Heterogeneous Palladium Catalysts in Coupling Reactions: the Case of Pd Loaded on Dealuminated Y Zeolites Palladium-Catalyzed Coupling Reactions with Magnetically Separable Nanocatalysts * The Use of Ordered Porous Solids as Support Materials in Palladium-Catalyzed Cross-Coupling Reactions * Coupling Reactions Induced by Polymer-Supported Catalysts * Coupling Reactions in Ionic Liquids * Cross-Coupling Reactions in Aqueous Media * Microwave-Assisted Synthesis in C-C and C-Heteroatom Coupling Reactions * Catalyst Recycling in Palladium-Catalyzed Carbon-Carbon Coupling Reactions * Nature of the True Catalytic Species in Carbon-Carbon Coupling Reactions with * Heterogeneous Palladium Precatalysts * Coupling Reactions in Continuous Flow Systems * Large-Scale Applications of Palladium-Catalyzed Couplings in the Pharmaceutical Industry

Author: Wei Du
Publisher:
ISBN: 9781361385456
Category :
Languages : en
Pages :

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This dissertation, "Palladium-catalyzed oxidative cascade cyclizations via C-N/C-C formation for synthesis of nitrogen heterocycles" by Wei, Du, 杜玮, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled PALLADIUM-CATALYZED OXIDATIVE CASCADE CYCLIZATIONS VIA C-N/C-C FORMATION FOR SYNTHESIS OF NITROGEN HETEROCYCLES submitted by Du Wei for the Degree of Doctor of Philosophy at The University of Hong Kong in May 2014 Pd(II)-catalyzed oxidative amination of alkenes is a versatile method to construct N-containing heterocycles which are found in many biologically active synthetic targets, including natural products and pharmaceuticals. Considering the efficiency of the cascade reaction, we have employed this protocol to synthesize nitrogen heterocycles (including chiral ones) via Pd(II)-catalyzed C-N/C-C bond formation. We have developed a highly efficient enantioselective method for oxidative cascade cyclization of acrylamides tethered alkene using Pd(TFA) /diPh-pyrox as catalyst under a mild aerobic condition (Scheme 1). A series of pyrrolizidine derivatives, such as 2.4a, 2.2h, and 2.2n, have been synthesized in good yields and excellent enantioselectivity. The mechanism study has indicated that the cyclization reaction proceeded through both trans-/cis-aminopalladation (AP) with a ratio of ca. 3:1 (Scheme 2). Besides, we have found that some factors, including the counterions of Pd(II) complexes, the electronic density of the isolated double bond and the steric bulkiness of ligands, affect the stereochemical selectivity in the aminopalladation step. This study has important implications for designing new catalyst systems for enantioselective Pd-catalyzed oxidative amination reactions. We have also disclosed the first enantioselective Pd(II)-catalyzed oxidative aminoarylation reaction (Scheme 3). The reactions were carried out with Pd(OAc) /β-ICD as catalyst to synthesize indoline derivatives, such as 3.2a, 3.2b and 3.2i, in moderate to good yields with moderate enantioselectivity. Base on previous successful cascade reactions of aminopalladation/C(sp )-H functionalization, we have developed a palladium (II)-catalyzed oxidative cascade aminoalkylation via aminopalladation/C(sp )-H activation for divergent synthesis of three-membered-ring (i.e. 4.2ag, 4.2an and 4.2ar) or five-membered-ring (i.e. 4.3aa, 4.3ad and 4.3bs) fused indolines (Scheme 4). The benzylic C-H and the C-H at -position of anilides can be selectively activated under different reaction conditions. 3 This is the first example of palladium catalyzed C(sp )-H activation without employment of prefunctionalized reagents (halogenated or boron-containing reagents) and directing groups, representing a green and economic protocol for construction of N-containing heterocycles. Scheme 1 Scheme 2 Scheme 3 Scheme 4 DOI: 10.5353/th_b5312312 Subjects: Heterocyclic compounds - Synthesis Organopalladium compounds

Author: Benjamin Ciszek
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: Michael Kenneth Ameriks
Publisher:
ISBN:
Category :
Languages : en
Pages : 952

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