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Author: Pedro Castelo-Branco Publisher: Academic Press ISBN: 0128164220 Category : Science Languages : en Pages : 490
Book Description
Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists
Author: Pedro Castelo-Branco Publisher: Academic Press ISBN: 0128164220 Category : Science Languages : en Pages : 490
Book Description
Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists
Author: L.S. Hnilica Publisher: CRC Press ISBN: 1351093843 Category : Medical Languages : en Pages : 297
Book Description
This book endeavours to present an analysis of the current knowledge of the structure properties and possible functions of histones. The broad scope of this topic prevents the discussion of certain individual aspects in any detail. For this purpose, some of the more specialised review articles should be consulted. However, the present volume will contribute to a more general understanding of histone biochemistry and will provide stimulation, as well as source references, to the student of the cell nucleus and its functions.
Author: Gary S. Stein Publisher: CRC Press ISBN: 9780849355158 Category : Science Languages : en Pages : 426
Book Description
This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.
Author: D. M. Philips Publisher: Springer Science & Business Media ISBN: 1468418157 Category : Science Languages : en Pages : 315
Book Description
The histones are now a very well established part of Biochemistry. The interpretation of all that is known about them, however, is already too great a burden for a single author to undertake. Indeed, a survey of the indexed literature shows that the number of publications on the histones has approximately doubled in every three years for the past 15 years, and is now several hundred a year. It is time then to bring together in one publication the major topics embraced by this great research effort. This book therefore endeavours to give, in six chapters, a broad and searching account of the biochemistry and biophysics of these interesting proteins and their complexes with nucleic acids, the nucleohistones. Each chapter is written by different authors who are all active in this research and who have had many years experience with these proteins and their complexes. Chapters 1, 2, part of 3, and all of Chapters 5 and 6, cover the occurrence, preparation, characterization, sequence structure, bio physical properties and finally, the biosynthesis and functions of the histones. The other part of Chapter 3, the whole of Chapter 4 and to a less extent some other chapters, all discuss the properties and structure of the nucleohistones. The study of these complexes is undoubtedly of great importance in bridging the gaps in our knowledge of template activity and differentiation as well as of chromosomal structure and mechanics.
Author: Renato Paro Publisher: Springer Nature ISBN: 3030686701 Category : Science Languages : en Pages : 215
Book Description
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Author: Raphaël Margueron Publisher: Springer Nature ISBN: 1071624814 Category : Science Languages : en Pages : 490
Book Description
This volume provides methods used to investigate histone methyltransferase function. Chapters guide readers through a comprehensive set of approaches that detail phylogenetic diversity, histone demethylase activities in vitro, generating chromatin substrates, auto-methylation, quantification of metabolites, protein purification, crystallization, X-ray structure, cryogenic electron microscopy, assessing genome-wide patterns, CUT&Tag in mouse embryonic tissues, chemical biology approaches, peptide SPOT arrays, nascent chromatin capture, ectopic protein tethering, computational models, and development of methyltransferase inhibitors. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Histone Methyltransferases: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Author: Tso-Pang Yao Publisher: Springer Science & Business Media ISBN: 3642216315 Category : Medical Languages : en Pages : 269
Book Description
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
Author: Dong Fang Publisher: Springer Nature ISBN: 9811581045 Category : Medical Languages : en Pages : 102
Book Description
This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
Author: Pedro Castelo-Branco
Author: Pedro Castelo-Branco
Author: L.S. Hnilica
Author: Gary S. Stein
Author: D. M. Philips
Author: 
Author: Renato Paro
Author: Raphaël Margueron
Author: Tso-Pang Yao
Author: Dong Fang
Author: Christiane Pienna Soares