High Altitude Sickness – Solutions from Genomics, Proteomics and Antioxidant Interventions PDF Download

Author: Narendra Kumar Sharma
Publisher: Springer Nature
ISBN: 9811910081
Category : Medical
Languages : en
Pages : 222

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Book Description
This book reviews the recent advances in the development of proteomics-based biomarkers for the non-invasive diagnosis of altitude sickness and explores the potential of antioxidant therapy for this sickness. The first chapters introduce the associated pathophysiology and provide mechanistic insights into the enhanced generation of reactive oxygen and nitrogen species (RONS), which leads to an increase in oxidative damage to lipids, proteins, and DNA. The book then highlights the current problems relating to the diagnosis and treatment of altitude sickness and summarizes novel approaches for identifying potential biomarkers and therapeutics. Lastly, it explores the therapeutic efficacy of antioxidant agents.

Author: Pranav Deepak Pathak
Publisher: CRC Press
ISBN: 1040008801
Category : Technology & Engineering
Languages : en
Pages : 404

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Book Description
Volume 1 of Computational Approaches in Bioengineering—Computational Approaches in Biotechnology and Bioinformatics—explores many significant topics of biomedical engineering and bioinformatics in an easily understandable format. It explores recent developments and applications in bioinformatics, biomechanics, artificial intelligence (AI), signal processing, wearable sensors, biomaterials, cell biology, synthetic biology, biostatistics, prosthetics, big data, and algorithms. From applications of biomaterials in advanced drug delivery systems to the role of big data, AI, and machine learning in disease diagnosis and treatment, the book will help readers understand how these technologies are being applied across the areas of biomedical engineering, bioinformatics, and healthcare. The chapters also include case studies on the role of medical robots in surgery and the determination of protein structure using genetic algorithms. The contributors are all leading experts across multiple disciplines and provide chapters that truly represent a complete view of these state-of-the-art technologies. FEATURES Covers a wide range of subjects from biomedical engineering like wearable devices, biomaterials, synthetic biology, phytochemical extraction, and prosthetics Explores AI, machine learning, big data analysis, and algorithms in biomedical engineering and bioinformatics in an easily understandable format Includes case studies on the role of medical robots in surgery and the determination of protein structure using genetic algorithms Discusses genetic diagnosis, classification, and risk prediction in cancer using next-generation sequencing in oncology This book is ideally designed for biomedical professionals, biomedical engineers, healthcare professionals, data engineers, clinicians, physicians, medical students, hospital directors, clinical researchers, and others who work in the field of artificial intelligence, bioinformatics, and computational biology.

Author: Seth Kwabena Amponsah
Publisher: Springer Nature
ISBN: 3031640217
Category : Pharmacology
Languages : en
Pages : 480

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Book Description
This book gives an overview of pharmacoproteomics and its clinical applications, as well as the latest information on drug mechanisms at the proteome level, the relationship between proteomics and toxicity or resistance, and how proteomics aid in discovery of new drug targets. The book also highlights recent advances in analytical methods, analysis, and interpretation of pharmacoproteomic data. Pharmacoproteomics: Recent Trends and Applications is an ideal book for those working in pharmaceutical industries, as well as scientists, health care professionals, and researchers who work in the field of genomics, pharmacology, pharmacokinetics, toxicology, and pharmaceutical chemistry.

Author: Pawan Kumar Maurya
Publisher: Springer
ISBN: 9811047111
Category : Science
Languages : en
Pages : 171

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Book Description
This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems. Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causative factor in many diseases, its prevention is vital, and there is an urgent need for oxidative stress monitoring using in vitro and in vivo models. Interdisciplinary approaches have lead to the development of various oxidative stress monitoring models for real-world clinical and biomedical applications. The development of such methods requires a broad understanding of biology, chemistry, molecular biology, immunology and microbiology. As such, the book is a valuable resource for students, researchers and clinicians interested in the fundamental as well as applied aspects of oxidative stress associated diseases.

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309477670
Category : Medical
Languages : en
Pages : 155

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Book Description
On December 5, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop titled Nutrigenomics and the Future of Nutrition in Washington, DC, to review current knowledge in the field of nutrigenomics as it relates to nutrition. Workshop participants explored the influence of genetic and epigenetic expression on nutritional status and the potential impact of personalized nutrition on health maintenance and chronic disease prevention. This publication summarizes the presentations and discussions from the workshop.

Author: Ignacio Rojas
Publisher: Springer
ISBN: 3030179354
Category : Computers
Languages : en
Pages : 605

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Book Description
The two-volume set LNBI 11465 and LNBI 11466 constitutes the proceedings of the 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, held in Granada, Spain, in May 2019. The total of 97 papers presented in the proceedings, was carefully reviewed and selected from 301 submissions. The papers are organized in topical sections as follows: Part I: High-throughput genomics: bioinformatics tools and medical applications; omics data acquisition, processing, and analysis; bioinformatics approaches for analyzing cancer sequencing data; next generation sequencing and sequence analysis; structural bioinformatics and function; telemedicine for smart homes and remote monitoring; clustering and analysis of biological sequences with optimization algorithms; and computational approaches for drug repurposing and personalized medicine. Part II: Bioinformatics for healthcare and diseases; computational genomics/proteomics; computational systems for modelling biological processes; biomedical engineering; biomedical image analysis; and biomedicine and e-health.

Author: Yasmin Ahmad
Publisher:
ISBN: 9781922227553
Category :
Languages : en
Pages : 94

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Book Description
High altitude physiology is one of the ignored domain of the scientific research despite of the massive scale of the problem, suggested by nearly 24% of the global population that either visits or dwells at high altitude and remain at the risk of hypoxia associated alterations in physiology. This lecture note entitled "Role of Proteomics in High altitude Pathophysiology" is designed especially for those who are interested in learning proteomics and their application in the field of high altitude physiology. It meets the needs of the proteomics studies prescribed for the high altitude physiology as it covers pathophysiology and molecular biology of high altitude sickness, proteomics as powerful tools and major proteomic advancements on pathophysiology of acute mountain sickness. This lecture notes has 5 units and can be completed in two sessions. Initially, we introduced the term hypobaric hypoxia as a socio-economic problem followed by the description of its pathophysiology. The later chapters describe the role of proteomics and key findings of our lab. Finally a last concluding chapter includes the future guidelines for improving the health benefits of the ongoing research and developing novel strategies for future research. Though this lecture note has been designed for the students of biology field, it would be useful also for clinical professionals in the early stage of their career. It would be helpful to anyone who desires to enhance their knowledge in the field of high altitude physiology.

Author: Kshipra Misra
Publisher: Academic Press
ISBN: 0128140003
Category : Science
Languages : en
Pages : 350

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Book Description
Management of High Altitude Pathophysiology presents a comprehensive overview on the various therapeutic practices and ongoing research relating to the development of more potent and novel formulations for managing high altitude pathophysiology. It provides a detailed application of both herbal and non-herbal therapeutic agents, including their nanoformulations. This important reference provides benefits to the medical and herbal scientific communities, doctors treating patients with high altitude complications, individuals travelling to high altitudes for recreation or work, and scientists working on future drug development. - Provides the recent advances and potential therapeutic agents for ameliorating the high-altitude complications - Includes herbal remedies for the prophylaxis and treatment of the high-altitude maladies - Elucidates the significance of Yogic practices and ergonomics in managing stress at high altitude

Author: Leonard Hayflick
Publisher:
ISBN: 9780345401557
Category : Aging
Languages : en
Pages : 0

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Book Description
"How long can humans live? Is immortality possible? Just what is the aging process? The aging and inevitable death of the human body have inspired more myths and outrageous quackery than anything else subject to scientific inquiry. . . . Now comes a most fascinating book, insightful and scholarly, to provide what answers have emerged so far." --San Francisco Chronicle Here, at last, preeminent cell biologist Leonard Hayflick presents the truth about human aging. Based on more than thirty years of pioneering research in the field, How and Why We Age explores not only how our major biological systems change as we grow older, but also examines the intangible alterations in our modes of thinking and feeling, our moods and sexual desires, our personality traits and our memories. With the immediacy of the latest scientific discoveries, Dr. Hayflick explains how aging affects every part of the body, and dispels many of the most persistent aging myths, to show that: * Hearts do not naturally get weaker with age. * Regular exercise and a low-fat diet won't slow aging. * Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years. * Only five percent of people over the age of sixty-five are in nursing homes * No human has lived--or probably can live--past 120 years. Gracefully written, clearly organized, and packed with essential facts and statistics, How and Why We Age is a landmark study of the aging process for readers of all ages. "Written in clear, nontechnical language, it is an excellent introduction to the scientific and demographic literature on this multifacetedsubject." --Nature

Author: Joseph F. Goldberg
Publisher: Cambridge University Press
ISBN: 1108450741
Category : Medical
Languages : en
Pages : 611

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Book Description
A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.