Author: Pedro Juez Martel
Publisher: Editorial Centro de Estudios Ramon Areces SA
ISBN: 8485942930
Category : Business & Economics
Languages : es
Pages : 510
Book Description
Un libro que pretende abarcar todas las fases de investigación de cualquier proyecto sanitario, abordando las técnicas más usadas en la investigación sanitaria desde una metodología eminentemente práctica. El esquema de la obra comprende el diseño del estudio, la selección y el cálculo del tamaño de la muestra, y el análisis de los datos a través del programa informático SPSS. Debido a la amplia experiencia del autor en la enseñanza a distancia de esta disciplina, el material está contrastado con la opinión de numerosos alumnos.
Herramientas estadísticas para la investigación en medicina y economía de la salud
Author: Pedro Juez Martel
Publisher: Editorial Centro de Estudios Ramon Areces SA
ISBN: 8485942930
Category : Business & Economics
Languages : es
Pages : 510
Book Description
Un libro que pretende abarcar todas las fases de investigación de cualquier proyecto sanitario, abordando las técnicas más usadas en la investigación sanitaria desde una metodología eminentemente práctica. El esquema de la obra comprende el diseño del estudio, la selección y el cálculo del tamaño de la muestra, y el análisis de los datos a través del programa informático SPSS. Debido a la amplia experiencia del autor en la enseñanza a distancia de esta disciplina, el material está contrastado con la opinión de numerosos alumnos.
Publisher: Editorial Centro de Estudios Ramon Areces SA
ISBN: 8485942930
Category : Business & Economics
Languages : es
Pages : 510
Book Description
Un libro que pretende abarcar todas las fases de investigación de cualquier proyecto sanitario, abordando las técnicas más usadas en la investigación sanitaria desde una metodología eminentemente práctica. El esquema de la obra comprende el diseño del estudio, la selección y el cálculo del tamaño de la muestra, y el análisis de los datos a través del programa informático SPSS. Debido a la amplia experiencia del autor en la enseñanza a distancia de esta disciplina, el material está contrastado con la opinión de numerosos alumnos.
Integrating Biomedical Information
Author: Assa Reichert
Publisher: IOS Press
ISBN: 9781586036140
Category : Medical
Languages : en
Pages : 430
Book Description
Organisations in health care are moving into the information age since two or three decades. Never was the pace of this movement as fast as today. "Integrating Biomedical Information: from e-Cell to e-Patient", the title of this EFMI publication, indicates the broad spectrum of Medical Informatics. Both concepts in the title are new - the result of data collection, data processing and information analysis. It is expected this data and information to be the knowledge base for a better understanding of mankind and also to assist us in making information (evidence) based decisions in health care. We expect that this will give us a better perspective of the human body, its functions and that it will ultimately lead us to better health care. Recent developments in clinical terminology construction have brought together specialists from different disciplines, such as Medicine, Computer Science, Philosophy, and Linguistics. Different genres of clinical terminologies co-exist: the former distinction between formal terminologies, classifications, vocabularies, nomenclatures and thesauri is increasingly being challenged by the notion of "ontology". There are controversies between linguistic approaches (aiming at representing term meanings) and ontological ones (which strive for a representation of biomedical reality). There is also an increasing quest for "good practice" recommendations for biomedical terminologies.) This book is the third volume of the EFMI STC conferences. This series is a subseries of the MIR-conferences published by IOS Press.
Publisher: IOS Press
ISBN: 9781586036140
Category : Medical
Languages : en
Pages : 430
Book Description
Organisations in health care are moving into the information age since two or three decades. Never was the pace of this movement as fast as today. "Integrating Biomedical Information: from e-Cell to e-Patient", the title of this EFMI publication, indicates the broad spectrum of Medical Informatics. Both concepts in the title are new - the result of data collection, data processing and information analysis. It is expected this data and information to be the knowledge base for a better understanding of mankind and also to assist us in making information (evidence) based decisions in health care. We expect that this will give us a better perspective of the human body, its functions and that it will ultimately lead us to better health care. Recent developments in clinical terminology construction have brought together specialists from different disciplines, such as Medicine, Computer Science, Philosophy, and Linguistics. Different genres of clinical terminologies co-exist: the former distinction between formal terminologies, classifications, vocabularies, nomenclatures and thesauri is increasingly being challenged by the notion of "ontology". There are controversies between linguistic approaches (aiming at representing term meanings) and ontological ones (which strive for a representation of biomedical reality). There is also an increasing quest for "good practice" recommendations for biomedical terminologies.) This book is the third volume of the EFMI STC conferences. This series is a subseries of the MIR-conferences published by IOS Press.
Hacia la cobertura universal en salud y la equidad en América Latina y el Caribe
Author: Tania Dmytraczenko
Publisher: World Bank Publications
ISBN: 1464811784
Category : Medical
Languages : en
Pages : 239
Book Description
En las ultimas tres decadas, muchos pafses en America Latina y el Caribe han reconocido el tema de la salud como un derecho humano. Desde inicios de la decada del 2000, 46 millones de personas adicionales, de los pafses estudiados, gozan de la protecci6n de programas de salud con explfcitos derechos a recibir atenci6n. Las reformas han venido acompafiadas por un incremento en el gasto publico del sector salud, financiado en gran pa rte por los ingresos fiscales generales que priorizan o estan dirigidos explfcitamente hacia las poblaciones sin capacidad de pago. Los compromisos polfticos se han traducido en general en presupuestos mas elevados yen leyes aprobadas que circunscriben los fondos destinados al sector salud. En la mayorfa de los pafses se ha priorizado la atenci6n primaria en salud por su costo efectividad y han adoptado metodos de adquisici6n que incentivan la eficiencia y la transparencia en los resultados y que les dan a los administradores del sector salud un mayor apalancamiento para dirigir a los proveedores hacia la . consecuci6n de las prioridades de salud publica. Sin embargo, a pesar de los avances. aun subsisten las disparidades en el financiamiento y calidad de los servicios de los subsistemas de salud. Cumplir con el compromiso de la cobertura universal de salud exigira esfuerzos concertados para mejorar la generaci6n de los ingresos fiscales de manera sostenible y de elevar la productividad y efectividad del gasto. En el re po rte Hacia la cobertura universal en salud v la equidad en America Latina v el Caribe: Evidencia de poises seleccionados. los autores sefialan que la evidencia tomada de un analisis de 54 encuestas de hogares corrobora que las inversiones en la ampliaci6n de la cobertura estan generando resultados. A pesar que los pobres aun presentan los peores fndices de salud en comparaci6n con los ricos, las disparidades se han reducido en gran medida, especialmente durante las primeras etapas de vida. Los pafses han alcanzado elevados niveles de cobertura y equidad en la utilizaci6n de los servicios de salud maternoinfantil. El panorama se torna mas lleno de matices y no tan positivo cuando se trata de la salud en adultos y de la prevalencia de condiciones y enfermedades cr6nicas. La cobertura de las intervenciones de enfermedades no transmisibles no es muy alta y la utilizaci6n de los servicios se inclina hacia aquellos que gozan de una mejor posici6n. La prevalencia de las enfermedades no transmisibles no ha mostrado el comportamiento esperado en vista de la cafda en las tasas de mortalidad: un mayor acceso a los servicios de diagn6stico por pa rte de los segmentos mas ricos podrfa encubrir cambios en la prevalencia real. Los gastos de salud provocados por situaciones catastr6ficas han ido en descenso en la mayorfa de los pafses. El panorama en torno a la equidad, sin embargo es mixto, apuntando hacia limitaciones en la medida. Si bien la tasa de empobrecimiento a causa de gastos de salud es baja, con tendencia decreciente en terminos generales, entre dos y cuatro millones de personas en los pafses estudiados aun caen por debajo de la lfnea de la pobreza despues de haber incurrido en gastos de salud. Los esfuerzos para darle un seguimiento sistematico a la calidad de la atenci6n en la region, apenas dan sus primeros pasos. Sin embargo, un repaso a la literatura revela graves deficiencias en la calidad de la atenci6n de salud, asi como sustanciales diferencias entre los diversos subsistemas. Elevar la calidad de la atenci6n y asegurar la sostenibilidad de las inversiones en salud siguen siendo una agenda inconclusa.
Publisher: World Bank Publications
ISBN: 1464811784
Category : Medical
Languages : en
Pages : 239
Book Description
En las ultimas tres decadas, muchos pafses en America Latina y el Caribe han reconocido el tema de la salud como un derecho humano. Desde inicios de la decada del 2000, 46 millones de personas adicionales, de los pafses estudiados, gozan de la protecci6n de programas de salud con explfcitos derechos a recibir atenci6n. Las reformas han venido acompafiadas por un incremento en el gasto publico del sector salud, financiado en gran pa rte por los ingresos fiscales generales que priorizan o estan dirigidos explfcitamente hacia las poblaciones sin capacidad de pago. Los compromisos polfticos se han traducido en general en presupuestos mas elevados yen leyes aprobadas que circunscriben los fondos destinados al sector salud. En la mayorfa de los pafses se ha priorizado la atenci6n primaria en salud por su costo efectividad y han adoptado metodos de adquisici6n que incentivan la eficiencia y la transparencia en los resultados y que les dan a los administradores del sector salud un mayor apalancamiento para dirigir a los proveedores hacia la . consecuci6n de las prioridades de salud publica. Sin embargo, a pesar de los avances. aun subsisten las disparidades en el financiamiento y calidad de los servicios de los subsistemas de salud. Cumplir con el compromiso de la cobertura universal de salud exigira esfuerzos concertados para mejorar la generaci6n de los ingresos fiscales de manera sostenible y de elevar la productividad y efectividad del gasto. En el re po rte Hacia la cobertura universal en salud v la equidad en America Latina v el Caribe: Evidencia de poises seleccionados. los autores sefialan que la evidencia tomada de un analisis de 54 encuestas de hogares corrobora que las inversiones en la ampliaci6n de la cobertura estan generando resultados. A pesar que los pobres aun presentan los peores fndices de salud en comparaci6n con los ricos, las disparidades se han reducido en gran medida, especialmente durante las primeras etapas de vida. Los pafses han alcanzado elevados niveles de cobertura y equidad en la utilizaci6n de los servicios de salud maternoinfantil. El panorama se torna mas lleno de matices y no tan positivo cuando se trata de la salud en adultos y de la prevalencia de condiciones y enfermedades cr6nicas. La cobertura de las intervenciones de enfermedades no transmisibles no es muy alta y la utilizaci6n de los servicios se inclina hacia aquellos que gozan de una mejor posici6n. La prevalencia de las enfermedades no transmisibles no ha mostrado el comportamiento esperado en vista de la cafda en las tasas de mortalidad: un mayor acceso a los servicios de diagn6stico por pa rte de los segmentos mas ricos podrfa encubrir cambios en la prevalencia real. Los gastos de salud provocados por situaciones catastr6ficas han ido en descenso en la mayorfa de los pafses. El panorama en torno a la equidad, sin embargo es mixto, apuntando hacia limitaciones en la medida. Si bien la tasa de empobrecimiento a causa de gastos de salud es baja, con tendencia decreciente en terminos generales, entre dos y cuatro millones de personas en los pafses estudiados aun caen por debajo de la lfnea de la pobreza despues de haber incurrido en gastos de salud. Los esfuerzos para darle un seguimiento sistematico a la calidad de la atenci6n en la region, apenas dan sus primeros pasos. Sin embargo, un repaso a la literatura revela graves deficiencias en la calidad de la atenci6n de salud, asi como sustanciales diferencias entre los diversos subsistemas. Elevar la calidad de la atenci6n y asegurar la sostenibilidad de las inversiones en salud siguen siendo una agenda inconclusa.
Herramientas estadísticas para la investigación en Medicina y Economía de la salud
Author: Pedro Juez Martel
Publisher:
ISBN: 9788480044233
Category :
Languages : es
Pages : 493
Book Description
Publisher:
ISBN: 9788480044233
Category :
Languages : es
Pages : 493
Book Description
Measuring and Valuing Health Benefits for Economic Evaluation
Author: John Brazier
Publisher: Oxford University Press
ISBN: 0198725922
Category : Business & Economics
Languages : en
Pages : 373
Book Description
There are not enough resources in health care systems around the world to fund all technically feasible and potentially beneficial health care interventions. Difficult choices have to be made, and economic evaluation offers a systematic and transparent process for informing such choices. A key component of economic evaluation is how to value the benefits of health care in a way that permits comparison between health care interventions, such as through costs per quality-adjusted life years (QALY). Measuring and Valuing Health Benefits for Economic Evaluation examines the measurement and valuation of health benefits, reviews the explosion of theoretical and empirical work in the field, and explores an area of research that continues to be a major source of debate. It addresses the key questions in the field including: the definition of health, the techniques of valuation, who should provide the values, techniques for modelling health state values, the appropriateness of tools in children and vulnerable groups, cross cultural issues, and the problem of choosing the right instrument. This new edition contains updated empirical examples and practical applications, which help to clarify the readers understanding of real world contexts. It features a glossary containing the common terms used by practitioners, and has been updated to cover new measures of health and wellbeing, such as ICECAP, ASCOT and AQOL. It takes into account new research into the social weighting of a QALY, the rising use of ordinal valuation techniques, use of the internet to collect data, and the use of health state utility values in cost effectiveness models. This is an ideal resource for anyone wishing to gain a specialised understanding of health benefit measurement in economic evaluation, especially those working in the fields of health economics, public sector economics, pharmacoeconomics, health services research, public health, and quality of life research.
Publisher: Oxford University Press
ISBN: 0198725922
Category : Business & Economics
Languages : en
Pages : 373
Book Description
There are not enough resources in health care systems around the world to fund all technically feasible and potentially beneficial health care interventions. Difficult choices have to be made, and economic evaluation offers a systematic and transparent process for informing such choices. A key component of economic evaluation is how to value the benefits of health care in a way that permits comparison between health care interventions, such as through costs per quality-adjusted life years (QALY). Measuring and Valuing Health Benefits for Economic Evaluation examines the measurement and valuation of health benefits, reviews the explosion of theoretical and empirical work in the field, and explores an area of research that continues to be a major source of debate. It addresses the key questions in the field including: the definition of health, the techniques of valuation, who should provide the values, techniques for modelling health state values, the appropriateness of tools in children and vulnerable groups, cross cultural issues, and the problem of choosing the right instrument. This new edition contains updated empirical examples and practical applications, which help to clarify the readers understanding of real world contexts. It features a glossary containing the common terms used by practitioners, and has been updated to cover new measures of health and wellbeing, such as ICECAP, ASCOT and AQOL. It takes into account new research into the social weighting of a QALY, the rising use of ordinal valuation techniques, use of the internet to collect data, and the use of health state utility values in cost effectiveness models. This is an ideal resource for anyone wishing to gain a specialised understanding of health benefit measurement in economic evaluation, especially those working in the fields of health economics, public sector economics, pharmacoeconomics, health services research, public health, and quality of life research.
Machine Learning
Author: Ethem Alpaydin
Publisher: MIT Press
ISBN: 0262529513
Category : Computers
Languages : en
Pages : 225
Book Description
A concise overview of machine learning—computer programs that learn from data—which underlies applications that include recommendation systems, face recognition, and driverless cars. Today, machine learning underlies a range of applications we use every day, from product recommendations to voice recognition—as well as some we don't yet use everyday, including driverless cars. It is the basis of the new approach in computing where we do not write programs but collect data; the idea is to learn the algorithms for the tasks automatically from data. As computing devices grow more ubiquitous, a larger part of our lives and work is recorded digitally, and as “Big Data” has gotten bigger, the theory of machine learning—the foundation of efforts to process that data into knowledge—has also advanced. In this book, machine learning expert Ethem Alpaydin offers a concise overview of the subject for the general reader, describing its evolution, explaining important learning algorithms, and presenting example applications. Alpaydin offers an account of how digital technology advanced from number-crunching mainframes to mobile devices, putting today's machine learning boom in context. He describes the basics of machine learning and some applications; the use of machine learning algorithms for pattern recognition; artificial neural networks inspired by the human brain; algorithms that learn associations between instances, with such applications as customer segmentation and learning recommendations; and reinforcement learning, when an autonomous agent learns act so as to maximize reward and minimize penalty. Alpaydin then considers some future directions for machine learning and the new field of “data science,” and discusses the ethical and legal implications for data privacy and security.
Publisher: MIT Press
ISBN: 0262529513
Category : Computers
Languages : en
Pages : 225
Book Description
A concise overview of machine learning—computer programs that learn from data—which underlies applications that include recommendation systems, face recognition, and driverless cars. Today, machine learning underlies a range of applications we use every day, from product recommendations to voice recognition—as well as some we don't yet use everyday, including driverless cars. It is the basis of the new approach in computing where we do not write programs but collect data; the idea is to learn the algorithms for the tasks automatically from data. As computing devices grow more ubiquitous, a larger part of our lives and work is recorded digitally, and as “Big Data” has gotten bigger, the theory of machine learning—the foundation of efforts to process that data into knowledge—has also advanced. In this book, machine learning expert Ethem Alpaydin offers a concise overview of the subject for the general reader, describing its evolution, explaining important learning algorithms, and presenting example applications. Alpaydin offers an account of how digital technology advanced from number-crunching mainframes to mobile devices, putting today's machine learning boom in context. He describes the basics of machine learning and some applications; the use of machine learning algorithms for pattern recognition; artificial neural networks inspired by the human brain; algorithms that learn associations between instances, with such applications as customer segmentation and learning recommendations; and reinforcement learning, when an autonomous agent learns act so as to maximize reward and minimize penalty. Alpaydin then considers some future directions for machine learning and the new field of “data science,” and discusses the ethical and legal implications for data privacy and security.
Textbook of Patient Safety and Clinical Risk Management
Author: Liam Donaldson
Publisher: Springer Nature
ISBN: 3030594033
Category : Medical
Languages : en
Pages : 496
Book Description
Implementing safety practices in healthcare saves lives and improves the quality of care: it is therefore vital to apply good clinical practices, such as the WHO surgical checklist, to adopt the most appropriate measures for the prevention of assistance-related risks, and to identify the potential ones using tools such as reporting & learning systems. The culture of safety in the care environment and of human factors influencing it should be developed from the beginning of medical studies and in the first years of professional practice, in order to have the maximum impact on clinicians' and nurses' behavior. Medical errors tend to vary with the level of proficiency and experience, and this must be taken into account in adverse events prevention. Human factors assume a decisive importance in resilient organizations, and an understanding of risk control and containment is fundamental for all medical and surgical specialties. This open access book offers recommendations and examples of how to improve patient safety by changing practices, introducing organizational and technological innovations, and creating effective, patient-centered, timely, efficient, and equitable care systems, in order to spread the quality and patient safety culture among the new generation of healthcare professionals, and is intended for residents and young professionals in different clinical specialties.
Publisher: Springer Nature
ISBN: 3030594033
Category : Medical
Languages : en
Pages : 496
Book Description
Implementing safety practices in healthcare saves lives and improves the quality of care: it is therefore vital to apply good clinical practices, such as the WHO surgical checklist, to adopt the most appropriate measures for the prevention of assistance-related risks, and to identify the potential ones using tools such as reporting & learning systems. The culture of safety in the care environment and of human factors influencing it should be developed from the beginning of medical studies and in the first years of professional practice, in order to have the maximum impact on clinicians' and nurses' behavior. Medical errors tend to vary with the level of proficiency and experience, and this must be taken into account in adverse events prevention. Human factors assume a decisive importance in resilient organizations, and an understanding of risk control and containment is fundamental for all medical and surgical specialties. This open access book offers recommendations and examples of how to improve patient safety by changing practices, introducing organizational and technological innovations, and creating effective, patient-centered, timely, efficient, and equitable care systems, in order to spread the quality and patient safety culture among the new generation of healthcare professionals, and is intended for residents and young professionals in different clinical specialties.
Counselling in Primary Health Care
Author: Jane Keithley
Publisher:
ISBN: 9780192631565
Category : Psychology
Languages : en
Pages : 0
Book Description
This book will be an invaluable resource for GPs, counsellors, managers and others in primary care who seek to understand the debates about counselling and play a part in its future as part of health care. Its authors discuss the nature of counselling in this setting and the contribution itcan make in improving the care of patients with a variety of health problems. The authors include practitioners and academics, service providers and counselling clients, supporters and sceptics. Overall they offer a comprehensive and thought provoking guide to those responsible for commissioning,working with and providing counselling services in a health service that seeks to be increasingly primary care led and evidence based.This book discusses the establishment and evaluation of counselling services in primary care and the need to consider the most appropriate forms of service for different groups. It describes the specialist counselling services that are available to back up what can be provided as part of primarycare and the variety of organisations that can be approached for information and advice, and assesses the research evidence on the efficacy and cost effectiveness of counselling.A GP writes:'If ever there was a subject guaranteed to generate debate, often heated, it's counselling. Does it work? Who's it for? What does it cost? How can we set up a service? Well, this book has the answers. And not just the positive ones - in the spirit of true balance, it even gives the sceptical view.A bit like turkeys voting for Christmas you might think? Nothing of the kind. The chapters cover just about everything GPs or Primary Care Organisations (PCO) might want to know about counselling in a primary care setting. In amongst the practical pointers on how to deal with thorny clinicalcounselling problems in specific situations, it even covers cost-effectiveness. Even the most sceptic, hard-hearted PCO clinical director will find the arguments in this book persuasive. The chapters on managed counselling, services for young people, substance misuse, trauma and sexual abuse couldeasily stand alone. But they don't. They are all in this little gem of a book. If not one for your doctor's bag, it's definitely one for your shelf!'
Publisher:
ISBN: 9780192631565
Category : Psychology
Languages : en
Pages : 0
Book Description
This book will be an invaluable resource for GPs, counsellors, managers and others in primary care who seek to understand the debates about counselling and play a part in its future as part of health care. Its authors discuss the nature of counselling in this setting and the contribution itcan make in improving the care of patients with a variety of health problems. The authors include practitioners and academics, service providers and counselling clients, supporters and sceptics. Overall they offer a comprehensive and thought provoking guide to those responsible for commissioning,working with and providing counselling services in a health service that seeks to be increasingly primary care led and evidence based.This book discusses the establishment and evaluation of counselling services in primary care and the need to consider the most appropriate forms of service for different groups. It describes the specialist counselling services that are available to back up what can be provided as part of primarycare and the variety of organisations that can be approached for information and advice, and assesses the research evidence on the efficacy and cost effectiveness of counselling.A GP writes:'If ever there was a subject guaranteed to generate debate, often heated, it's counselling. Does it work? Who's it for? What does it cost? How can we set up a service? Well, this book has the answers. And not just the positive ones - in the spirit of true balance, it even gives the sceptical view.A bit like turkeys voting for Christmas you might think? Nothing of the kind. The chapters cover just about everything GPs or Primary Care Organisations (PCO) might want to know about counselling in a primary care setting. In amongst the practical pointers on how to deal with thorny clinicalcounselling problems in specific situations, it even covers cost-effectiveness. Even the most sceptic, hard-hearted PCO clinical director will find the arguments in this book persuasive. The chapters on managed counselling, services for young people, substance misuse, trauma and sexual abuse couldeasily stand alone. But they don't. They are all in this little gem of a book. If not one for your doctor's bag, it's definitely one for your shelf!'
The Guide for the Perplexed
Author: Moses Maimonides
Publisher:
ISBN:
Category : Jewish philosophy
Languages : en
Pages : 498
Book Description
Publisher:
ISBN:
Category : Jewish philosophy
Languages : en
Pages : 498
Book Description
Innovation in Pharmacy: Advances and Perspectives. September 2018
Author: Organizer Committee IPAP18 – Salamanca
Publisher: Ediciones Universidad de Salamanca
ISBN: 8490129762
Category : Medical
Languages : es
Pages : 358
Book Description
This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The science that created this advance and its future promise will be discussed. Phillip Allen Sharp is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for “the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence. He works in Institute Professor Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, US. Este libro recoge los resúmenes de la «Innovation in Pharmacy: Advances and Perspectives» que tuvo lugar en Salamanca (España) en septiembre de 2018. La ciencia primitiva de la química y la microbiología fue la fuente de la mayoría de las drogas hasta la revolución de la ingeniería genética a mediados de la década de 1970. Luego, la biotecnología puso a disposición agentes proteínicos novedosos como interferones, factores sanguíneos y anticuerpos monoclonales que han cambiado la farmacia moderna. Durante el año pasado, surgió una nueva farmacia de oligonucleótidos a partir de la ciencia de la expresión génica, como el empalme de ARN y la interferencia de ARN. La capacidad de diseñar agentes terapéuticos a partir de secuencias genómicas transformará el tratamiento de muchas enfermedades. La ciencia que creó este avance y su promesa futura será discutida. Phillip Allen Sharp es un genetista y biólogo molecular estadounidense que co-descubrió el empalme de ARN. Compartió el Premio Nobel de 1993 en Fisiología o Medicina con Richard J. Roberts por "el descubrimiento de que los genes en eucariotas no son cadenas contiguas, sino que contienen intrones, y que el empalme del ARN mensajero para eliminar esos intrones puede ocurrir de diferentes maneras, produciendo diferentes proteínas de la misma secuencia de ADN. Trabaja en el Instituto Profesor Koch Institute for Integrative Cancer Research, Instituto Tecnológico de Massachusetts (MIT), Cambridge, MA, EE. UU.
Publisher: Ediciones Universidad de Salamanca
ISBN: 8490129762
Category : Medical
Languages : es
Pages : 358
Book Description
This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The science that created this advance and its future promise will be discussed. Phillip Allen Sharp is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for “the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence. He works in Institute Professor Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, US. Este libro recoge los resúmenes de la «Innovation in Pharmacy: Advances and Perspectives» que tuvo lugar en Salamanca (España) en septiembre de 2018. La ciencia primitiva de la química y la microbiología fue la fuente de la mayoría de las drogas hasta la revolución de la ingeniería genética a mediados de la década de 1970. Luego, la biotecnología puso a disposición agentes proteínicos novedosos como interferones, factores sanguíneos y anticuerpos monoclonales que han cambiado la farmacia moderna. Durante el año pasado, surgió una nueva farmacia de oligonucleótidos a partir de la ciencia de la expresión génica, como el empalme de ARN y la interferencia de ARN. La capacidad de diseñar agentes terapéuticos a partir de secuencias genómicas transformará el tratamiento de muchas enfermedades. La ciencia que creó este avance y su promesa futura será discutida. Phillip Allen Sharp es un genetista y biólogo molecular estadounidense que co-descubrió el empalme de ARN. Compartió el Premio Nobel de 1993 en Fisiología o Medicina con Richard J. Roberts por "el descubrimiento de que los genes en eucariotas no son cadenas contiguas, sino que contienen intrones, y que el empalme del ARN mensajero para eliminar esos intrones puede ocurrir de diferentes maneras, produciendo diferentes proteínas de la misma secuencia de ADN. Trabaja en el Instituto Profesor Koch Institute for Integrative Cancer Research, Instituto Tecnológico de Massachusetts (MIT), Cambridge, MA, EE. UU.