Chemistry and Toxicology of Pyrrolizidine Alkaloids PDF Download

Author: A. R. Mattocks
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 424

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Author: Helmut Wiedenfeld
Publisher: Vandenhoeck & Ruprecht
ISBN: 3899714261
Category : Pyrrolizidines
Languages : de
Pages : 145

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Book Description
Pyrrolizidine alkaloids show only minor toxicity in their native state, but are metabolized in the human or animal organisms to carcinogenic, teratogenic and mutagenic compounds, with the precise structure of these compounds being responsible for the metabolic toxification process. Therefore, to be able to evaluate the toxic potential of each alkaloid, it is essential to exactly know the structure of the respective compound. X-ray structure analysis is the appropriate method both for elucidating the structure and for determining other parameters, such as the lengths of the bonds that influence the metabolic process. This book describes the incidence and the process of the intoxication as well as the possibilities to how the substances may reach the organism. In addition, the compounds elucidated by X-ray structure analysis to date are shown in their three-dimensional structure and structure-toxicity relationships are discussed.Pyrrolizidinalkaloide weisen in nativem Zustand nur geringe Toxizität auf, werden jedoch zu kanzerogenen, teratogenen und mutagenen Verbindungen metabolisiert, wenn sie in den menschlichen oder tierischen Organismus gelangen. Der Verlauf dieser Toxifizierung hängt von der konkreten Struktur dieser Stoffe und weiteren Parametern ab. Zur Bestimmung dieser Faktoren stellt die Röntgenstrukturanalyse die geeignete Methode dar. Im vorliegenden Buch werden das Vorkommen, der Ablauf der Toxifizierung und die Möglichkeiten, wie die Stoffe in den Organismus gelangen können, beschrieben. Es werden die bislang durch Röntgenstrukturanalyse vermessenen Verbindungen in ihrer 3D-Struktur aufgefÃ"hrt und Struktur-Toxizitätsbeziehungen diskutiert.

Author: Michael W. Shannon
Publisher: Saunders
ISBN: 9780721606934
Category : Drugs
Languages : en
Pages : 0

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This edition is a reference for information related to the clinical management of children and adults whose health has been effected or potentially effected by toxic agents, including drugs, environmental threats, and natural toxins.

Author: Andrew G. Mtewa
Publisher: John Wiley & Sons
ISBN: 1119650232
Category : Science
Languages : en
Pages : 444

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Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Author: L. B. Bull
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 320

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Author: Bryan M. Waldridge
Publisher: John Wiley & Sons
ISBN: 1119191874
Category : Medical
Languages : en
Pages : 205

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Nutritional Management of Equine Diseases and Special Cases offers a concise, easy-to-comprehend text for equine veterinarians with questions about commonly encountered nutritional problems. Assists veterinarians in supporting equine patients with special nutritional needs Focuses on nutritional problems and impact on different body systems Covers ponies, miniature horses, draft horses, donkeys, and mules Offers complete coverage of common diseases and problems helped by nutrition Includes useful chapters on poisonous plants and mycotoxins

Author:
Publisher: Academic Press
ISBN: 0128173173
Category : Medical
Languages : en
Pages : 290

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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Author: Kip Eugene Panter
Publisher: Cabi
ISBN: 9781845932732
Category : Nature
Languages : en
Pages : 0

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Despite decades of research, poisonous plants continue to be responsible for large economic losses to livestock producers throughout the world. As the expansion into rural areas and the use of rangelands increases, an understanding of plant toxicology has become ever more important. This book represents the product of a wide-range of research aimed at solving the various issues surrounding poisonous plants. Broader themes include plant biochemistry, toxic effects in animals and humans, and rangeland management approaches to prevent poisoning amongst others. Individual chapters address plant animal relationships, various classes of secondary plant compounds, isolation, identification and effects of these toxins on biological mammalian systems and analytical methods, diagnostic tools and management strategies for plant toxicoses in animals and humans.

Author: Frederick J. Suchy
Publisher: Cambridge University Press
ISBN: 1139464035
Category : Medical
Languages : en
Pages : 995

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Book Description
Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

Author: Andrew Pengelly
Publisher: Routledge
ISBN: 1000247937
Category : Body, Mind & Spirit
Languages : en
Pages : 168

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Book Description
Pengelly's user friendly text will encourage educators in medical science to consider using this material in the complementary medicine/nutraceuticals areas May I congratulate Andrew Pengelly for writing this text as it is going to be very popular with undergraduate students as well as more experienced readers.' D. Green, London Metropolitan University, UK This unique book explains in simple terms the commonly occurring chemical constituents of medicinal plants. The major classes of plant constituents such as phenols, terpenes and polysaccharides, are described both in terms of their chemical structures and their pharmacological activities. Identifying specific chemical compounds provides insights into traditional and clinical use of these herbs, as well as potential for adverse reactions. Features include: * Over 100 diagrams of chemical structures * References to original research studies and clinical trials * References to plants commonly used throughout Europe, North America and Australasia. Written by an experienced herbal practitioner, The Constituents of Medicinal Plants seriously challenges any suggestion that herbal medicine remains untested and unproven, including as it does hundreds of references to original research studies and trials. Designed as an undergraduate text, the first edition of this book became an essential desktop reference for health practitioners, lecturers, researchers, producers and anyone with an interest in how medicinal herbs work. This edition has been extensively revised to incorporate up-to-date research and additional sections, including an expanded introduction to plant molecular structures, and is destined to become a classic in the literature of herbal medicine.