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Author: J. Miklossy Publisher: IOS Press ISBN: 1614997063 Category : Medical Languages : en Pages : 420
Book Description
Alzheimer’s disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer’s disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century. In recent years, evidence of the microbial origin of various chronic inflammatory disorders – including several neurodegenerative, neuropsychiatric and other systemic disorders – has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer’s disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions. This handbook assembles and connects findings with regard to the infectious origin of Alzheimer’s disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer’s disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.
Author: J. Miklossy Publisher: IOS Press ISBN: 1614997063 Category : Medical Languages : en Pages : 420
Book Description
Alzheimer’s disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer’s disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century. In recent years, evidence of the microbial origin of various chronic inflammatory disorders – including several neurodegenerative, neuropsychiatric and other systemic disorders – has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer’s disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions. This handbook assembles and connects findings with regard to the infectious origin of Alzheimer’s disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer’s disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.
Author: Andrew E. Budson Publisher: John Wiley & Sons ISBN: 1118672852 Category : Psychology Languages : en Pages : 676
Book Description
The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field Summarizes the most recent developments in the fields of Alzheimer's disease and dementia Brings together articles from a prominent and international group of contributors Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences
Author: C.A. Raji Publisher: IOS Press ISBN: 1643684930 Category : Medical Languages : en Pages : 674
Book Description
It is almost 120 years since Alzheimer’s disease (AD) was first reported, and the concept of modifiable risk factors associated with the disease has been present from the outset. Thus, the idea of preventing AD is not new, with reference to strategies noted as early as the 1990s. This subfield of AD research has matured in recent years, with the number of modifiable risk factors – the AD preventome – rising from the 7 initially identified to the current 12, with an estimated contribution to dementia cases worldwide of about 40%. This book, the Handbook of Prevention and Alzheimer’s Disease, introduces physicians, scientists, and other stakeholders to this subfield of AD research. It investigates the AD preventome, which will continue to expand as the understanding of new factors and related biomarkers is refined. Optimizing this preventome leads to an improvement in overall brain health, an outcome which reduces the risk of developing AD and improves quality of life. The book goes on to examine other domains of prevention, from vascular risk factors to social engagement and from sleep health to spirituality. If the journey to end AD can be likened to a long and arduous challenge, understanding every possible part of the overall toolkit of approaches for disease prevention and intervention is essential. Together with its companion volume on intervention, the book provides a comprehensive overview of strategies for tackling Alzheimer’s disease, and will be of interest to all those working in the field. Cover illustration: White matter tracts showing sex differences in connectivity in men versus women as a function of increasing body mass index. Reprinted with permission from Rahmani F, Wang Q, McKay NS, Keefe S, Hantler N, Hornbeck R, Wang Y, Hassenstab J, Schindler S, Xiong C, Morris JC, Benzinger TLS, Raji CA. Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity. J Alzheimers Dis. 2022;86(4):1831-1848. doi: 10.3233/JAD-215329. PMID: 35180116; PMCID: PMC9108572.
Author: G.M. Pasinetti Publisher: IOS Press ISBN: 164368289X Category : Medical Languages : en Pages : 732
Book Description
Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host’s biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease’, sets out to explore the complex role of the microbiome with regard to Alzheimer’s disease (AD). The microbiome is a critical and often overlooked aspect of immunity, which in turn plays a role in cognition. The book presents current research into the gut microbiota and its far-reaching impacts on cognitive function and neurodegeneration. Interventions, including probiotic supplementation, fecal transfer, and supplementation with microbial metabolites, are discussed, as is the use of certain probiotics to study the effects of the gut microbiota on behavior and cognitive function, and as potential therapeutics for AD. Other topics covered include the influence of the gut and oral microbiota on immune inflammatory signals: cytokines, neuroendocrine hormones, bacterial components, neuroactive molecules, and microbial metabolites. The book is divided into four sections, each covering a research area pertinent to the gut-brain-axis and its relationship with cognitive function and AD. It will be of interest to all those whose work includes the study and understanding of these complex, multi-variable biological mechanisms, particularly in the context of cognitive function and AD. The cover shows a color edited MRI image of a sagittal section of a neurological control brain of Dr. Giulio Maria Pasinetti.
Author: Elaine A. Moore Publisher: McFarland ISBN: 1476678618 Category : Health & Fitness Languages : en Pages : 233
Book Description
With the recent discovery that amyloid beta protein, the cause of plaques in Alzheimer's disease, is an antimicrobial peptide produced in response to infection, many researchers are focusing on the role infection plays in the development of Alzheimer's disease. Brain studies have also identified a number of different viruses, bacteria, fungi, and protozoa in the postmortem brain specimens of Alzheimer's patients. Infection (particularly chronic, latent and persistent infections) causes an immune response that leads to inflammation and brain cell degeneration, which are characteristic features of Alzheimer's disease. Sources of infection in Alzheimer's disease vary from childhood infections to gut microbes that find their way into the brain as a result of aging, leaky gut syndrome, and increased permeability of the blood brain barrier. Studies and ongoing clinical trials show that treatment of viral and bacterial infections, as well as restoring a healthy balance to the gut microbiome, can reduce disease risk and improve symptoms in patients with Alzheimer's disease. This book serves as an introduction to the human microbiome and the role that infection plays in the development of Alzheimer's disease.
Author: Andrew E. Budson Publisher: ISBN: 9781782687443 Category : Dementia Languages : en Pages : 687
Book Description
The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced fieldSummarizes the most recent developments in the fields of Alzheimer's disease and dementiaBrings together articles from a prominent and international group of contributorsEncompasses a unique range of topics, combining basi.
Author: R. C. Hamdy Publisher: ISBN: Category : Medical Languages : en Pages : 488
Book Description
This text meets the needs of physicians, nurses, therapists, caregivers, and family members. It contains a wealth of practical information about the effects of Alzheimer's on the patient's day-to-day life, and offers detailed descriptions of the stages of the disease, the options for treatment, and the effects of other mental and physical characteristics upon the expression of Alzheimer's. Additionally, it offers valuable suggestions for approaching issues such as nutrition, sleep habits, safety, caregiver stress, and therapy. The book is a perfect bridge between an interdisciplinary panel of expert contributors who know most about the disease and those who know most about the patient. * Takes a reader-friendly look at the structure and function of the normal brain, along with the higher brain functions, providing the proper background needed to study the various types of dementia. * Explores the neuropsychological assessment of dementia as well as the tools, such as brain imaging, used in the process to lay a clinical foundation for the student. * Examines current concepts in the etiology and pathogenesis of Alzheimer's disease, as well as the pathology, clinical presentation, and clinical diagnosis of the disease to bring the reader up to speed on new and established research. * Compares and contrasts Alzheimer's disease with other forms of dementias so that the properties unique to Alzheimer's are well understood. * Presents the general principles of management of Alzheimer's along with ways to manage the difficult behaviors that accompany it. * Provides valuable information for dealing with everything from fecal and urinary incontinence to preventing accidents in the home to managing daily care and planning activities. * Analyzes ethical and legal issues involved in caregiving, an area that continues to grow in complexity. * Details the many avenues of community support, from social services to the Alzheimer's Association. * Provides a glossary so that the reader has quick access to the definitions of important terms.
Author: Marc E. Agronin Publisher: Lippincott Williams & Wilkins ISBN: 9780781767705 Category : Medical Languages : en Pages : 372
Book Description
Now in its Second Edition, this practical guide focuses on assessment, diagnosis, and management of the complex array of dementia disorders seen in older patients. Using the conversational style and clinical vignettes found in all Practical Guides in Psychiatry titles, Dr. Agronin addresses all the subtypes of dementia and associated psychiatric conditions such as agitation, psychosis, and depression. This edition features a new chapter on mild cognitive impairment and expanded coverage of Alzheimer disease and risk factors. Chapters offer advice on caregiver support and legal and ethical concerns. Handy pocket-card appendices include tests used in the dementia workup and treatment guides for agitation, psychosis, and depression. The Practical Guides in Psychiatry series provides quick, concise information for professionals on the front lines of mental health care. Written in an easy-to-read, conversational style, these invaluable resources take you through each step of the psychiatric care process, delivering fast facts and helpful strategies that help you provide effective and compassionate care to your patients.
Author: J. Miklossy
Author: J. Miklossy
Author: Andrew E. Budson
Author: C.A. Raji
Author: G.M. Pasinetti
Author: 
Author: Elaine A. Moore
Author: Andrew E. Budson
Author: R. C. Hamdy
Author: 
Author: Marc E. Agronin