Handbook of Dystonia PDF Download

Author: Mark A. Stacy
Publisher: CRC Press
ISBN: 1841848522
Category : Medical
Languages : en
Pages : 562

View

Book Description
As many as 250,000 people in the United States have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease.Authoritative and reader-friendly, Handbook of Dystonia, Second Edition provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, an

Author: A. P. Moore
Publisher: Wiley-Blackwell
ISBN: 9780632059577
Category : Medical
Languages : en
Pages : 476

View

Book Description
Botulinum toxin A is a remarkably versatile treatment with a steadily expanding list of indications, which include strabismus, hemifacial spasm, focal dystonias such as spasmodic torticollis, dysphonia and writer’s cramp, as well as adult and childhood spasticity. Recent innovations include its use in some types of pain, in autonomic and gastrointestinal disorders, and in cosmetic medicine, such as hyperhidrosis, hypersalivation, rectal fissure, achalasia and facial wrinkles. Botulinum toxin is arguably the safest and most effective treatment in movement disorders since the introduction of levodopa, and is an increasingly important option in many other fields. The long-awaited second edition of the Handbook of Botulinum Toxin Treatment brings the reader up to date with the many advances in background knowledge and in clinical practice in both the established and the newer indications, including the use of a second serotype botulinum toxin B. The book is an introduction and practical guide for doctors and paramedical staff who use botulinum toxin or who may want to refer patients or care for patients being treated elsewhere. Initial chapters provide historical and general information. The rest of the book concentrates on the different conditions treated with botulinum toxin. Chapters follow a standard format with a pragmatic approach based on the wide experience of the authors.

Author: KUMAR, NAVNEET
Publisher: PHI Learning Pvt. Ltd.
ISBN: 8119364007
Category : Medical
Languages : en
Pages : 310

View

Book Description
There is a dearth of books on neurological examination that give a comprehensive analysis of the subject. Dr. Navneet Kumar, with his expertise and vast teaching as well as practising experience, provides tips to the students and practitioners to conduct neurological examination of the patients in a scientific and systematic manner. He shows with, great skill, how the examination of first impression and gait, history taking, and examination of higher mental functions including speech are to be conducted. The book, in the Second Edition, has been updated and enhanced by introducing more illustrations and visuals for clear understanding and diagnosis of diseases and disorders. The text focuses on the examination of all the cranial nerves (First to Twelfth), the motor system, movement disorders, the sensory system, the autonomic nervous system, and bladder dysfunction, with equal deftness, besides other important concepts. This systematically organised book provides different approaches to examine the unconscious patient, and special neurological situations, the methods of neurological investigation, as well as the methods of case sheet writing. Primarily intended as a practical handbook for the students of MBBS, MD (Medicine), DNB (Medicine), Paediatrics and Psychiatry, the book would also be of great value to the students pursuing DM (Neurology) and M.Ch. (Neurosurgery) as well as practising physicians and neurologists. KEY FEATURES • Gives anatomical details of all cranial nerves. • Highlights common problems in neurology, generally not mentioned in any other handbook. • Provides about 200 real photographs and diagrams, and also a large number of tables to illustrate the concepts. • Includes a thorough analysis of neurological investigations. TARGET AUDIENCE • MBBS / MD (Medicine) / DNB (Medicine) • Paediatrics & Psychiatry • DM (Neurology) / M.Ch. (Neurosurgery)

Author: Daniel Truong
Publisher: Cambridge University Press
ISBN: 1107654335
Category : Medical
Languages : en
Pages : 321

View

Book Description
Fully updated throughout, the second edition of the Manual of Botulinum Toxin Therapy provides practical guidance on the use of Botox in a wide variety of disorders. New chapters have been added on the use of botulinum toxin in wound healing, in focal hand dystonia and in thoracic outlet syndrome, as well as others. There are new chapters on the use of botulinum toxins in conjunction with ultrasound guidance. Using clear line-drawings the Manual describes the relevant injection sites for each condition and gives comparative dosage tables for the various formulations of toxins used in different muscle groups. Throughout the emphasis is on technique and the book can be used as both a teaching aid and in bedside guidance. The manual will be of use to neurologists, otolaryngologists, urologists, ophthalmologists, dermatologists, internists, pain management specialists, rehabilitation specialists and plastic surgeons, and any other clinicians discovering the potential of botulinum toxin.

Author: Karen Frei, MD
Publisher: Springer Publishing Company
ISBN: 1934559407
Category : Medical
Languages : en
Pages : 131

View

Book Description
Spasmodic torticollis, also known as cervical dystonia, affects about three people in 10,000, or an estimated 85,000 individuals in the United States alone. Despite this, there has been until now a lack of information outside of the professional medical literature for use by individuals with this disorder and their families. This book provides comprehensive information on the disorder for people with spasmodic torticollis and those close to them. Medical terms and concepts are introduced sequentially and then used as building blocks for the later discussion. Beginning with a clear definition of the disorder, opening chapters categorize this neurologic disease as one of the broader category of movement disorders, and differentiate it from other conditions with which it is often confused. The authors then present a stepwise introduction to the relevant anatomy and physiology of the nervous system and neck. They draw on the experiences of their patients to build a progressive depiction of the experiences an individual might have as he or she goes through the initial onset of symptoms, progression of the disorder, seeking medical care, diagnosis, treatment, and subsequent outcome. Personal vignettes from the experiences of selected patients are provided where they illustrate particular points in the discussion. Subsequent chapters discuss various modes of treatment for spasmodic torticollis. Prior to the mid-1980?s, there were no specific treatments for this disorder. Nearly all treatment consisted of using oral medications that were primarily intended for other medical conditions. Since most of these medications are still in use, and a few new ones have been added, a chapter is devoted to detailing them and discussing the general principles of medication therapy. During the past decade, chemodenervation using botulinum toxin has become the primary and most effective treatment for spasmodic torticollis. For those few patients who require surgery, a description is provided of the neurosurgical techniques developed during the last twenty years specifically for its treatment. The final chapter is a manual of therapeutic rehabilitation exercises designed to alleviate the symptoms of spasmodic torticollis. These exercises can be performed by most patients with no assistance and a bare minimum of equipment. Since each person?s case of spasmodic torticollis is different, only certain of the exercises may be appropriate for any given individual. They should be undertaken only after discussion with your physician. These exercises are accompanied by detailed illustrations that emphasize the particular muscles relevant to each posture or movement. About the Authors: Dr. Pathak is a neurologist with a special interest in the neurologic rehabilitation of movement disorders, especially spasmodic torticollis. Dr. Frei is a neurologist specialized in the field of neurogenetics, and has conducted clinical trials on a number of movement disorders, including spasmodic torticollis. Dr. Truong is a neurologist and movement disorders specialist. He has conducted active research in the management of movement disorders, including spasmodic torticollus. He was one of the pioneers in the use of botulinum toxin to manage this condition, and has lectured worldwide on the management of movement disorders.

Author:
Publisher: Demos Medical Publishing
ISBN: 9781617050312
Category : Medical
Languages : en
Pages : 466

View

Book Description
"Rating scales are used daily by everyone involved in the management of patients with neurologic disease and in the design and management of neurologic clinical trials. Now there is a single source for the wide range of scales used in specific neurologic diseases and neurorehabilitation. You will refer to this volume constantly! The first edition of the Handbook of Neurologic Rating Scales quickly became an invaluable reference work on the increasing array of scales for measuring neurologic disease. In the brief few years since the first edition the importance of this book has only increased. New Chapters Include Scales On: Generic and general use Pediatric neurology and rehabilitation Peripheral neuropathy and pain Ataxia HIV/AIDS And instruments for diagnosing headaches. Formal measurement of the effects of neurologic disease and of treatment effects, beyond the description of changes on the standard neurologic examination, is a relatively recent development. Controlled clinical trials and outcomes research are at the heart of modern information-based medicine, and neurologic scales are essential tools in clinical trials designed to provide this information. A Resource for Clinical Trials The Handbook of Neurologic Rating Scales provides a resource for clinicians and clinical investigators in the broad field of neurology and neurologic rehabilitation to help them: evaluate the clinical trials literature by providing information on the scales being used evaluate and select appropriate and efficient scales for clinical trials and outcomes research, and provide information that will help them to develop new scales or measures or to improve existing ones. A Resource for Evaluating Disease Status Outcomes research is playing an increasingly important role in clinical management and neurorehabilitation, and these also depend largely on measurement of disease status and change. In this era of managed care, neurologists must produce outcomes data demonstrating the effectiveness of neurologic care if the specialty is to survive, and certainly if it is to thrive. Even effective therapies are likely to fall by the wayside if studies to prove their effectiveness are not done. Comprehensive and Standardized Information on All Scales Each chapter in this volume contains the scales of importance and in current use, including a sequence of scale descriptions and specific scales in a standard format, as well as a summary and recommendations indicating which scales are most useful for specific purposes and whether a combination of scales is particularly useful or if better scales are needed. Each entry notes: the purpose for which the scale was developed and its current uses if they differ from those for which it was developed a detailed description of the scale information about validation, such as: Does the scale have face validity? i.e., does it appear to measure what it purports to measure? how and by whom the scale is administered the time needed to administer and score the scale the scale itself or, when the scale is proprietary or too long for inclusion, a description and key references special considerations, including unusual measures needed to obtain a valid score or problems in administering the test in specific patients advantages, or what makes the scale good or useful. Disadvantages, or what makes the scale difficult to use or impairs its reliability key references, including the original publication of the scale and its validation Downloadable PDFs of the scales contained in the Handbook of Neurologic Rating Scales are included with the purchase of this book. The password to download the files can be found in the book itself.

Author: Ivan Donaldson
Publisher: Oxford University Press
ISBN: 0191502243
Category : Medical
Languages : en
Pages : 1512

View

Book Description
This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.

Author: Heinz Steiner
Publisher: Academic Press
ISBN: 9780123747679
Category : Medical
Languages : en
Pages : 693

View

Book Description
The Basal Ganglia comprise a group of forebrain nuclei which are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control, cognition, and mnemonic functions, and the importance of these nuclei for normal brain function and behavior is emphasized by the numerous disorders associated with basal ganglia dysfunction - Parkinson's, Tourette's, Huntington's, cerebral palsy, ADHD, OCD, and others. the Handbook provides a comprehensive overview of the structural and functional organization of the basal ganglia, w

Author: Dirk Dressler
Publisher: Cambridge University Press
ISBN: 1316997936
Category : Medical
Languages : en
Pages : 481

View

Book Description
Our understanding of dystonia is advancing rapidly. This comprehensive reference work provides an effective guide to this challenging group of disorders, offering an overview of the current and emerging treatment options for all manifestations. Treatments for the many forms of dystonia differ substantially in pediatrics and adults - both are covered in detail in this book. Approaches include botulinum toxin therapy, deep brain stimulation, oral drug applications, rehabilitation, and behavioral and experimental therapies. Special emphasis is also given to combining different treatment modalities in order to achieve optimal effect. Treatment of Dystonia brings together peer-reviewed articles, written by experts and based on work presented at international conferences. By enabling the physician to select and combine the best therapies, it is an essential resource for neurologists, neurosurgeons and physical therapists.

Author: Sarfaraz K. Niazi
Publisher: CRC Press
ISBN: 1482226375
Category : Medical
Languages : en
Pages : 1012

View

Book Description
As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have made bioequivalence testing more complex. The second edition of Handbook of Bioequivalence Testing has been completely updated to include the most current information available, including new findings in drug delivery and dosage form design and revised worldwide regulatory requirements. New topics include: A historical perspective on generic pharmaceuticals New guidelines governing submissions related to bioequivalency studies, along with therapeutic code classifications Models of noninferiority Biosimilarity of large molecule drugs Bioequivalence of complementary and alternate medicines Bioequivalence of biosimilar therapeutic proteins and monoclonal antibodies New FDA guidelines for bioanalytical method validation Outsourcing and monitoring of bioequivalence studies The cost of generic drugs is rising much faster than in the past, partly because of the increased costs required for approval—including those for bioequivalence testing. There is a dire need to re-examine the science behind this type of testing to reduce the burden of development costs—allowing companies to develop generic drugs faster and at a lower expense. The final chapter explores the future of bioequivalence testing and proposes radical changes in the process of biowaivers. It suggests how the cost of demonstrating bioequivalence can be reduced through intensive analytical investigation and proposes that regulatory agencies reduce the need for bioequivalence studies in humans. Backed by science and updated with the latest research, this book is destined to spark continued debate on the efficacy of the current bioequivalence testing paradigm.