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Author: Publisher: Scholar Press ISBN: 6202306238 Category : Languages : en Pages : 268
Book Description
The theoretical background of this work is concerning with the drug loaded polyelectrolyte multilayers (PEM) modified by the host-guest interaction of biocompatible hyperbranched core-shell glycopolymers. The glycopolymer in this work is the hyperbranched polyethyleneimine that was modified with maltose moieties using reductive amination. Thus, the use of glycohyperbranched polymers for drug delivery would allow the avoid naturally occurring drug resistance due to decreased transporter activity. Concerning preparative method, PEM was fabricated using layer-by-layer (LbL) processes involve the sequential deposition of two polyions that physically bond together. Control was taken on the stoichiometric ratio related to cationic and anionic repeating units, which was chosen close to zero for the final applied PEM. Concerning analytical methods, a couple of physical-chemical methods were applied to characterize colloid stability, adhesiveness, drug loading and release of fabricated PEM. In conclusion, a highly sable and sustainable PEM coats on a surface of an activated solid substrate has been fabricated with an efficient ability to recycle the charged molecule for more than 24 times.
Author: Publisher: Scholar Press ISBN: 6202306238 Category : Languages : en Pages : 268
Book Description
The theoretical background of this work is concerning with the drug loaded polyelectrolyte multilayers (PEM) modified by the host-guest interaction of biocompatible hyperbranched core-shell glycopolymers. The glycopolymer in this work is the hyperbranched polyethyleneimine that was modified with maltose moieties using reductive amination. Thus, the use of glycohyperbranched polymers for drug delivery would allow the avoid naturally occurring drug resistance due to decreased transporter activity. Concerning preparative method, PEM was fabricated using layer-by-layer (LbL) processes involve the sequential deposition of two polyions that physically bond together. Control was taken on the stoichiometric ratio related to cationic and anionic repeating units, which was chosen close to zero for the final applied PEM. Concerning analytical methods, a couple of physical-chemical methods were applied to characterize colloid stability, adhesiveness, drug loading and release of fabricated PEM. In conclusion, a highly sable and sustainable PEM coats on a surface of an activated solid substrate has been fabricated with an efficient ability to recycle the charged molecule for more than 24 times.
Author: Ravin Narain Publisher: John Wiley & Sons ISBN: 1118002245 Category : Technology & Engineering Languages : en Pages : 416
Book Description
This book addresses the need for a comprehensive book on the design, synthesis, and characterization of synthetic carbohydrate-based polymeric materials along with their biological applications. The first two chapters cover the synthesis and self-assembly of glycopolymers and different techniques for creating these synthetic polymers. Subsequent chapters account for the preparation of block copolymers, branched glycopolymers, glycosurfaces, glycodendrimers, cationic glycopolymers, bioconjugates, glyconanoparticles and hydrogels. While these chapters comprehensively review the synthetic and characterization methods of those carbohydrate-based materials, their biological applications are discussed in detail.
Author: Solar Candido Ademola Olugebefola Publisher: ISBN: Category : Languages : en Pages : 155
Book Description
Polyelectrolyte multilayer (PEM) assembly is a technology for building thin films with a number of useful and novel functionalities. PEMs interact favorably with proteins and other biomolecules making them potentially valuable as biomaterials. Many systems of polymers have been studied for use in PEMs, including weak polyelectrolytes such as those containing poly(acrylic acid) (PAA) and poly(allyamine hydrochloride) (PAH), which exhibit pH-dependent behavior. Properties such as thickness, swellability, mechanical stiffness, porosity (and by extention optical properties), and ability to adsorb small molecules are all controlled by the charge density of these polymers in the film and their resultant binding state. Patterning covalent binding through photo-crosslinking in addition to electrostatic binding, can locally override the native tendency to change structure with changes in pH. To achieve this, poly(acrylic acid) was chemically modified through a halide esterification reaction to incorporate photo-crosslinkable vinylbenzyl side groups, making poly(acrylic acid-ran-vinylbenzyl acrylate) (PAArVBA). The chemical modification was characterized by nuclear magnetic resonance spectroscopy (NMR) and light spectroscopy.
Author: Phuong Nguyen Tri Publisher: Elsevier ISBN: 0128168919 Category : Technology & Engineering Languages : en Pages : 558
Book Description
Smart Nanocontainers explores the fundamental concepts and emerging applications of nanocontainers in biomedicine, pharmaceuticals and smart materials. In pharmaceuticals, nanocontainers have advantages over their micro-counterparts, including more efficient drug detoxification, higher intracellular uptake, better stability, less side effects and higher biocompatibility with tissue and cells. In materials science, such as coating technology, they help by making coatings smarter, stronger and more durable. This important reference will help anyone who wants to learn more on how nanocontainers are used to provide the controlled release of active agents, including their applications in smart coatings, corrosion, drug delivery, diagnosis, agri-food and gas storage. Discusses how the molecular design of nanocarriers can be optimized to increase performance Explores how nanocarriers are being used to produce a new generation of active coatings Explains how nanocarriers are being used to deliver more effective nanoscale drug delivery
Author: Michael C. Berg (Ph. D.) Publisher: ISBN: Category : Languages : en Pages : 312
Book Description
(cont.) In the final part of this thesis, the antibacterial properties of both silver-loaded polyelectrolyte multilayers and superhydrophobic multilayers are examined. It was found that silver loaded multilayers killed bacteria to an extent greater than 99.99% for both airborne and waterborne models. Superhydrophobic films showed excellent anti-fouling properties for proteins, mammalian cells, and bacteria.
Author: David Sustr Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Research on novel and advanced biomaterials is an indispensable step towards their applications in desirable fields such as tissue engineering, regenerative medicine, cell culture, or biotechnology. The work presented here focuses on such a promising material: polyelectrolyte multilayer (PEM) composed of hyaluronic acid (HA) and poly(L-lysine) (PLL). This gel-like polymer surface coating is able to accumulate (bio-)molecules such as proteins or drugs and release them in a controlled manner. It serves as a mimic of the extracellular matrix (ECM) in composition and intrinsic properties. These qualities make the HA/PLL multilayers a promising candidate for multiple bio-applications such as those mentioned above. The work presented aims at the development of a straightforward approach for assessment of multi-fractional diffusion in multilayers (first part) and at control of local molecular transport into or from the multilayers by laser light trigger (second part). The mechanism of the loading and release is governed by the interaction ...
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Author: Samaa Ragab Ali Ragab Salem
Author: Sukant K. Tripathy
Author: Sukant K. Tripathy
Author: Ravin Narain
Author: Anne Palermo
Author: Solar Candido Ademola Olugebefola
Author: Phuong Nguyen Tri
Author: Michael C. Berg (Ph. D.)
Author: David Sustr