Genetic Perspectives in Thyroid Cancer PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Genetic Perspectives in Thyroid Cancer PDF full book. Access full book title Genetic Perspectives in Thyroid Cancer by Susana Nunes Silva. Download full books in PDF and EPUB format.
Author: Susana Nunes Silva Publisher: MDPI ISBN: 303650544X Category : Medical Languages : en Pages : 118
Book Description
Thyroid cancer is an uncommon type of cancer, but it is one of the most common endocrine malignancies. The etiology of thyroid cancer is multifactorial, and radiation is the best documented risk factor related to the disease. Further risk factors have been hypothesized; however, we have yet to gather a wide range of information that will help us better understand the genetic mechanisms of thyroid cancer. The influence of genetics in the clinic and in therapeutics has been improved based on retrospective and prospective studies published worldwide in the last few decades, but the development of high through-put approaches has also been crucial. The new advances in high through-put methodologies such as next generation sequencing will open the door to new genetic variants that will help to clarify genotype–phenotype correlations, new gene associations, new genetic targets useful as potential biomarkers, and so on. The new decade that is now beginning may provide new evidence for the disease. “Genetic Perspectives in Thyroid Cancer” is an issue that intends to cover several topics on thyroid cancer, aiming to reach new findings based on genetic evidence in thyroid cancer as expressed in case studies, molecular approaches, and hereditary evidences, clinical and therapeutic developments.
Author: Susana Nunes Silva Publisher: MDPI ISBN: 303650544X Category : Medical Languages : en Pages : 118
Book Description
Thyroid cancer is an uncommon type of cancer, but it is one of the most common endocrine malignancies. The etiology of thyroid cancer is multifactorial, and radiation is the best documented risk factor related to the disease. Further risk factors have been hypothesized; however, we have yet to gather a wide range of information that will help us better understand the genetic mechanisms of thyroid cancer. The influence of genetics in the clinic and in therapeutics has been improved based on retrospective and prospective studies published worldwide in the last few decades, but the development of high through-put approaches has also been crucial. The new advances in high through-put methodologies such as next generation sequencing will open the door to new genetic variants that will help to clarify genotype–phenotype correlations, new gene associations, new genetic targets useful as potential biomarkers, and so on. The new decade that is now beginning may provide new evidence for the disease. “Genetic Perspectives in Thyroid Cancer” is an issue that intends to cover several topics on thyroid cancer, aiming to reach new findings based on genetic evidence in thyroid cancer as expressed in case studies, molecular approaches, and hereditary evidences, clinical and therapeutic developments.
Author: Angela Greco Publisher: Elsevier Inc. Chapters ISBN: 0128061138 Category : Medical Languages : en Pages : 42
Book Description
Thyroid cancer represents the most common endocrine malignancy and its incidence is increasing. The majority of thyroid tumours (90–95%) originate from the follicular epithelial cells; it includes several histotypes and related variants characterized by different biological and clinical behavior, such as differentiated papillary and follicular carcinoma (PTC and FTC), and poorly differentiated and anaplastic carcinoma (PDTC and ATC). Medullary thyroid carcinoma (MTC) represents a small fraction of thyroid tumors and originates from the parafollicular C cells. PTCs feature a frequent deregulation of the MAPK pathway, as RET/PTC, TRK, RAS or BRAF oncogenes have been found in about 70% of cases. FTCs are associated with RAS mutations and PAX8/PPARγ oncogenic chromosome rearrangements. PDTCs and ATCs display some alterations occurring in differentiated tumors, as well as other alterations specific of late tumor stages. MTC carry RET or RAS mutations. Here we summarize the molecular alterations detected in each thyroid tumor type, their role in the process of thyroid carcinogenesis, as well as how high-throughput gene expression analyses have contributed to the study of this malignancy.
Author: T. Akamizu Publisher: Springer Science & Business Media ISBN: 4431678859 Category : Medical Languages : en Pages : 242
Book Description
The rapid developments in molecular genetics have clarified many of the muta tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin guished researchers from the United States, the United Kingdom, France, Ger many, Italy, and Japan were invited. Each presentation precipitated intense dis cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.
Author: Syed Z. Ali Publisher: Springer Science & Business Media ISBN: 0387876669 Category : Medical Languages : en Pages : 257
Book Description
This atlas is the offspring of the “The National Cancer Institute (NCI) Thyroid Fine Needle Aspiration (FNA) State of the Science Conference,” hosted by the NCI and organized by Dr. Andrea Abati. Preparations for the conference began 18 months earlier with the designation of a steering committee and the establishment of a dedicated, p- manent web site. The meeting took place on October 22 and 23, 2007 in Bethesda, Maryland and was co-moderated by Susan J. Mandel and Edmund S. Cibas. The discussions and conclusions regarding terminology and morphologic criteria 1, 2 from the meeting were summarized in publications by Baloch et al. and form the framework for this atlas. The atlas is organized by the general categories of “Nondiagnostic,” “Benign,” “Follicular Neoplasm/Suspicious for a Follicular Neoplasm”, “Suspicious for Malignancy,” and “Malignant,” and it includes the defi- tions and morphologic criteria of these categories as set forth by Baloch et al. The majority of the conference participants also agreed on a category of “undetermined significance,” which is incorporated in this atlas (Chap. 4). It is critical that the cytopathologist communicate thyroid FNA interpretations to the referring physician in terms that are succinct, unambiguous, and helpful clinically. We recognize that the terminology used here is a flexible framework that can be modified by individual laboratories to meet the needs of their providers and the patients they serve.
Author: Daniela Gabriele Grimm Publisher: MDPI ISBN: 3038424765 Category : Science Languages : en Pages : 221
Book Description
This book is a printed edition of the Special Issue "Current Knowledge in Thyroid Cancer—From Bench to Bedside" that was published in IJMS
Author: Glenn D. Braunstein Publisher: Springer Science & Business Media ISBN: 146140875X Category : Medical Languages : en Pages : 319
Book Description
The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the United States, with three-quarters occurring in women. The overall 5-year survival rate is about 97%, making it one of the least lethal cancers. We are experiencing an epidemic of well-differentiated thyroid cancer, in part due to the widespread use of imaging modalities that detect thyroid nodules and microcarcinomas. Concurrently, there have been a number of recent advances in surgical treatment, as well as diagnostic modalities that allow us to detect small amounts of residual local and metastatic disease. Additionally, a reexamination of past treatment regimens has led to new recommendations regarding the use of radioactive iodine, and to new therapeutic options, such as targeted therapy which have supplanted the use of more toxic chemotherapy for metastatic cancer. Multiple academic organizations have developed consensus guidelines for the management of thyroid cancer, occasionally with conflicting recommendations. In Thyroid Cancer, a renowned group of authors presents a broad overview of the pathology, pathophysiology, diagnosis, and management of thyroid cancer, with an emphasis on recent evidence-based information. State-of-the-art and a significant contribution to the literature, Thyroid Cancer is an invaluable reference for endocrinologists, oncologists, nuclear medicine physicians, radiation oncologists, primary care physicians, and surgeons who deal with head and neck cancer.
Author: Susana Nunes Silva
Author: Susana Nunes Silva
Author: Ujjal K. Mallick
Author: Vasyl Vasko
Author: Angela Greco
Author: T. Akamizu
Author: Syed Z. Ali
Author: Daniela Gabriele Grimm
Author: Cesar Seigi Fuziwara
Author: Ifigenia Kostoglou-Athanassiou
Author: Glenn D. Braunstein