Functionalized mesoporous silica nanoparticles for stimuli-responsive and targeted drug delivery PDF Download

Author: Nikola Knezevic
Publisher:
ISBN:
Category :
Languages : en
Pages : 96

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Book Description

Author: Nikola Knežević
Publisher:
ISBN:
Category :
Languages : en
Pages : 96

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Book Description

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 104

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Book Description
Construction of functional supramolecular nanoassemblies has attracted great deal of attention in recent years for their wide spectrum of practical applications. Mesoporous silica nanoparticles (MSN) in particular were shown to be effective scaffolds for the construction of drug carriers, sensors and catalysts. Herein, we describe the synthesis and characterization of stimuli-responsive, controlled release MSN-based assemblies for drug delivery.

Author: Amit Singh
Publisher: Royal Society of Chemistry
ISBN: 1788011139
Category : Medical
Languages : en
Pages : 376

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Book Description
This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.

Author: Valentina Cauda
Publisher: MDPI
ISBN: 3039439391
Category : Science
Languages : en
Pages : 204

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Book Description
Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.

Author: Deepa H. Patel
Publisher: CRC Press
ISBN: 1000517594
Category : Science
Languages : en
Pages : 228

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Book Description
This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.

Author: Carmen Alvarez-Lorenzo
Publisher: Royal Society of Chemistry
ISBN: 1849734313
Category : Technology & Engineering
Languages : en
Pages : 419

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Book Description
Smart materials, which can change properties when an external stimulus is applied, can be used for the targeted drug delivery of an active molecule to a specific site in the correct dosage. Different materials such as liposomes, polymeric systems, nanomaterials and hydrogels can respond to different stimuli such as pH, temperature and light and these are all attractive for controlled release applications. With so many papers available on smart and stimuli-responsive materials for drug delivery applications it's hard to know where to start reading about this exciting topic. This two volume set brings together the recent findings in the area and provides a critical analysis of the different materials available and how they can be applied to advanced drug delivery systems. With contributions from leading experts in the field, including a foreword from distinguished scientist Nicholas Peppas, The University of Texas at Austin, USA, the book will provide both an introduction to the key areas for graduate students and new researchers in the stimuli-responsive field as well as serving as a reference for those already working on fundamental materials research or drug delivery applications.

Author: Mariela A. Agotegaray
Publisher: Springer
ISBN: 3319501585
Category : Technology & Engineering
Languages : en
Pages : 93

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Book Description
This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.

Author: David J. Hauss
Publisher: CRC Press
ISBN: 1420017268
Category : Medical
Languages : en
Pages : 370

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Book Description
Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem

Author: Chi-An Cheng
Publisher:
ISBN:
Category :
Languages : en
Pages : 326

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Book Description
This dissertation makes contributions to the fields of formulation and delivery of anticancer drugs, antibiotics, and imaging agents, primarily focused on engineering mesoporous silica nanoparticles (MSNs) for stimuli-responsive drug delivery. The strategies and techniques developed in this dissertation will be especially useful for achieving precision medicine or personalized medicine, which is defined as the "right drug, right dosage at right timing to right patient". Although various emerging approaches for personalized disease treatment that take individual variability into account have been developed, the necessity of delivering the desired therapeutics at the desired time to the specific site of the disease and with accurate dosage remains a challenge. Here we first review the previously reported stimuli-responsive MSNs controlled by supramolecular nanomachines for antibiotic and drug delivery. In the second part of the dissertation, we report novel MSNs-based nanoparticles engineered to be responsive to noninvasive stimuli, such as alternating magnetic field (AMF) or high-intensity focused ultrasound (HIFU). AMF-responsive drug delivery demonstrates the controlled therapeutic efficacy for pancreatic cancer cells in vitro by adjusting different lengths of AMF exposure time. The HIFUresponsive MSNs provide a promising platform for magnetic resonance imaging (MRI)-guided HIFU (MRgHIFU)-stimulated cargo delivery. The change of T1 reports on the amount of released cargo which is imageable by MRI ex vivo. Both AMF-and MRgHIFU-stimulation strategies offer the potential for the spatial, temporal, and dosage control of drug delivery. In the last part, we develop an approach to achieve both high loading and high release amount of a water-insoluble antibiotic clofazimine (CFZ) carried by MSNs by using acetophenone (AP) as a chaperone molecule, solving the water insolubility problem faced when treating multidrug-resistant tuberculosis. The treatment of Mycobacterium tuberculosis infected macrophages with optimized CFZ-loaded MSNs shows good therapeutic efficacy in vitro. Finally, we develop a hollow mesoporous silica nanoparticle (HMSN) formulated near infrared (NIR) fluorophore IR-140, to realize a novel biocompatible shortwave infrared (SWIR) optical imaging contrast agent for bioimaging with a higher tissue penetration depth. The J-aggregates of IR-140 stabilized inside HMSNs showed the potential to overcome the stability, toxicity, and brightness challenges faced by common SWIR contrast agents.