Author: Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 162
Book Description
First Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 162
Book Description
First Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: First Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: Conference on DNA Topoisomerases in Cancer ChemotherapyPublisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 149
Book Description
First Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 149
Book Description
First Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: Milan PotmesilPublisher:
ISBN:
Category : Cancer
Languages : en
Pages : 149
Book Description
DNA Topoisomerases in Cancer Therapy
Author: Toshiwo AndohPublisher: Springer Science & Business Media
ISBN: 9780306477447
Category : Medical
Languages : en
Pages : 224
Book Description
This volume commemorates the 30th anniversary of the discovery in 1971 of the first DNA topoisomerases, i.e topoisomerase I in E. coli, then provisionally named `omega' protein, by the pioneering work of Jim Wang at Harvard University, who has contributed an article to this volume: `Reflections on an accidental discovery' of the enzyme. Many kinds of topoisomerase have since been found from type I through to type VI in a variety of organisms ranging from viruses to higher eukaryote mammals. The wide distribution of enzymes in various forms of life implies that the DNA topoisomerase is essential for life. In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.
Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy
Author: Toshiwo AndohPublisher: CRC Press
ISBN: 9780849349706
Category : Medical
Languages : en
Pages : 400
Book Description
Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.
Conference on DNA Topoisomerases in Cancer Chemotherapy
Author: Milan PotmesilDNA Topoisomerases and Cancer
Author: Yves PommierPublisher: Springer Science & Business Media
ISBN: 1461403235
Category : Medical
Languages : en
Pages : 443
Book Description
DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.
The Fifth Conference on DNA Topoisomerases in Therapy
Author: New York University. Medical CenterPublisher:
ISBN:
Category : Cancer
Languages : en
Pages : 53
Book Description