Molecular Evolutionary Models in Drug Discovery PDF Download

Author: Juan Bueno
Publisher: Academic Press
ISBN: 0128189290
Category : Medical
Languages : en
Pages : 194

View

Book Description
Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. - Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms - Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs - Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

Author: Robert J Marks Ii
Publisher: World Scientific
ISBN: 9813142162
Category : Computers
Languages : en
Pages : 331

View

Book Description
Science has made great strides in modeling space, time, mass and energy. Yet little attention has been paid to the precise representation of the information ubiquitous in nature.Introduction to Evolutionary Informatics fuses results from complexity modeling and information theory that allow both meaning and design difficulty in nature to be measured in bits. Built on the foundation of a series of peer-reviewed papers published by the authors, the book is written at a level easily understandable to readers with knowledge of rudimentary high school math. Those seeking a quick first read or those not interested in mathematical detail can skip marked sections in the monograph and still experience the impact of this new and exciting model of nature's information.This book is written for enthusiasts in science, engineering and mathematics interested in understanding the essential role of information in closely examined evolution theory.

Author: Jonathan Wells
Publisher: Simon and Schuster
ISBN: 159698533X
Category : Science
Languages : en
Pages : 251

View

Book Description
Everything you were taught about evolution is wrong.

Author: David Young
Publisher: Cambridge University Press
ISBN: 0521868033
Category : Science
Languages : en
Pages : 12

View

Book Description
A compelling journey of discovery uncovering some of the mysteries of evolution.

Author: Alex A. Freitas
Publisher: Springer Science & Business Media
ISBN: 3662049236
Category : Computers
Languages : en
Pages : 272

View

Book Description
This book integrates two areas of computer science, namely data mining and evolutionary algorithms. Both these areas have become increasingly popular in the last few years, and their integration is currently an active research area. In general, data mining consists of extracting knowledge from data. The motivation for applying evolutionary algorithms to data mining is that evolutionary algorithms are robust search methods which perform a global search in the space of candidate solutions. This book emphasizes the importance of discovering comprehensible, interesting knowledge, which is potentially useful for intelligent decision making. The text explains both basic concepts and advanced topics

Author: Donald R. Prothero
Publisher: Columbia University Press
ISBN: 0231548850
Category : Science
Languages : en
Pages : 588

View

Book Description
The theory of evolution unites the past, present, and future of living things. It puts humanity’s place in the universe into necessary perspective. Despite a history of controversy, the evidence for evolution continues to accumulate as a result of many separate strands of amazing scientific sleuthing. In The Story of Evolution in 25 Discoveries, Donald R. Prothero explores the most fascinating breakthroughs in piecing together the evidence for evolution. In twenty-five vignettes, he recounts the dramatic stories of the people who made crucial discoveries, placing each moment in the context of what it represented for the progress of science. He tackles topics like what it means to see evolution in action and what the many transitional fossils show us about evolution, following figures from Darwin to lesser-known researchers as they unlock the mysteries of the fossil record, the earth, and the universe. The book also features the stories of animal species strange and familiar, including humans—and our ties to some of our closest relatives and more distant cousins. Prothero’s wide-ranging tales showcase awe-inspiring and bizarre aspects of nature and the powerful insights they give us into the way that life works. Brisk and entertaining while firmly grounded in fundamental science, The Story of Evolution in 25 Discoveries is a captivating read for anyone curious about the evidence for evolution and what it means for humanity.

Author: Richard McElreath
Publisher: University of Chicago Press
ISBN: 0226558282
Category : Social Science
Languages : en
Pages : 429

View

Book Description
Over the last several decades, mathematical models have become central to the study of social evolution, both in biology and the social sciences. But students in these disciplines often seriously lack the tools to understand them. A primer on behavioral modeling that includes both mathematics and evolutionary theory, Mathematical Models of Social Evolution aims to make the student and professional researcher in biology and the social sciences fully conversant in the language of the field. Teaching biological concepts from which models can be developed, Richard McElreath and Robert Boyd introduce readers to many of the typical mathematical tools that are used to analyze evolutionary models and end each chapter with a set of problems that draw upon these techniques. Mathematical Models of Social Evolution equips behaviorists and evolutionary biologists with the mathematical knowledge to truly understand the models on which their research depends. Ultimately, McElreath and Boyd’s goal is to impart the fundamental concepts that underlie modern biological understandings of the evolution of behavior so that readers will be able to more fully appreciate journal articles and scientific literature, and start building models of their own.

Author: Daniel R. Brooks
Publisher: University of Chicago Press
ISBN: 9780226075891
Category : Science
Languages : en
Pages : 698

View

Book Description
All living things on earth—from individual species to entire ecosystems—have evolved through time, and evolution is the acknowledged framework of modern biology. Yet many areas of biology have moved from a focus on evolution to much narrower perspectives. Daniel R. Brooks and Deborah A. McLennan argue that it is impossible to comprehend the nature of life on earth unless evolution—the history of organisms—is restored to a central position in research. They demonstrate how the phylogenetic approach can be integrated with ecological and behavioral studies to produce a richer and more complete picture of evolution. Clearly setting out the conceptual, methodological, and empirical foundations of their research program, Brooks and McLennan show how scientists can use it to unravel the evolutionary history of virtually any characteristic of any living thing, from behaviors to ecosystems. They illustrate and test their approach with examples drawn from a wide variety of species and habitats. The Nature of Diversity provides a powerful new tool for understanding, documenting, and preserving the world's biodiversity. It is an essential book for biologists working in evolution, ecology, behavior, conservation, and systematics. The argument in The Nature of Diversity greatly expands upon and refines the arguments made in the authors' previous book Phylogeny, Ecology, and Behavior.

Author: National Academy of Sciences
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 388

View

Book Description
The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.

Author: Aharon Kantorovich
Publisher: State University of New York Press
ISBN: 1438408331
Category : Philosophy
Languages : en
Pages : 298

View

Book Description
Kantorovich analyzes the notion of discovery. He views the process as inference and questions whether there is logic or method to discovery. He provides an alternative perspective on scientific discovery that explains the difficulties in finding a satisfactory method of discovery. Within the framework of evolutionary epistemology, discovery is treated as a phenomenon in its own right having psychological and social dimensions. Science is viewed as a continuation of the evolutionary process whereby creative discovery plays a role similar to blind mutation in biological evolution. From this perspective, serendipity and tinkering are key notions in understanding the creative process.