Evaluation of OECD Screening Tests 421 (reproduction, Developmental Toxicity Screening Test) and 422 (combined Repeated Dose Toxicity Study with the Reproduction, Developmental Toxicity Screening Test) PDF Download

Author:
Publisher:
ISBN: 9783777612003
Category : Toxicity testing
Languages : en
Pages : 84

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Author: OECD
Publisher: OECD Publishing
ISBN: 9264070982
Category :
Languages : en
Pages : 14

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The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...

Author:
Publisher:
ISBN: 9783777611631
Category :
Languages : de
Pages : 96

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Author: OECD
Publisher: OECD Publishing
ISBN: 9264070966
Category :
Languages : en
Pages : 10

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The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...

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ISBN:
Category :
Languages : en
Pages : 19

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This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination. The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 63 days. Matings "one male to one female" should normally be used in this study. This Test Guideline is designed for use with the rat. It is recommended that each group be started with at least 10 animals of each sex. Generally, at least three test groups and a control group should be used. Dose levels may be based on information from acute toxicity tests or on results from repeated dose studies. The test substance is administered orally and daily. The results of this study include clinical observations, body weight and food/water consumption, oestrous cycle monitoring, offspring parameters observation/measurement, thyroid hormone measurement, as well as gross necropsy and histopathology. The findings of this toxicity study should be evaluated in terms of the observed effects, necropsy and microscopic findings. Because of the short period of treatment of the male, the histopathology of the testis and epididymus should be considered along with the fertility data, when assessing male reproductive effects.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Organisation de coopération et de développement économiques
Publisher:
ISBN:
Category :
Languages : en
Pages : 14

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Book Description
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination. The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 63 days. Matings "one male to one female" should normally be used in this study. This Test Guideline is designed for use with the rat. It is recommended that each group be started with at least 10 animals of each sex. Generally, at least three test groups and a control group should be used. Dose levels may be based on information from acute toxicity tests or on results from repeated dose studies. The test substance is administered orally and daily. The results of this study include clinical observations, body weight and food/water consumption, oestrous cycle monitoring, offspring parameters observation/measurement, thyroid hormone measurement, as well as gross necropsy and histopathology. The findings of this toxicity study should be evaluated in terms of the observed effects, necropsy and microscopic findings. Because of the short period of treatment of the male, the histopathology of the testis and epididymus should be considered along with the fertility data, when assessing male reproductive effects.

Author: OECD
Publisher: OECD Publishing
ISBN: 9264070869
Category :
Languages : en
Pages : 13

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This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and ...

Author: Robert W. Kapp
Publisher: CRC Press
ISBN: 1420073443
Category : Medical
Languages : en
Pages : 422

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Book Description
Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology's contributors are experienced regulatory agency and Clinical Research Organization representatives w

Author: OECD
Publisher: OECD Publishing
ISBN: 9264221352
Category :
Languages : en
Pages : 213

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This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs).