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Author: W. Wayne Lautt Publisher: Morgan & Claypool Publishers ISBN: 1615040099 Category : Science Languages : en Pages : 174
Book Description
The Hepatic circulation is unique among vascular beds. The most obvious unique features include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery (the hepatic arterial buffer response); the fact that portal blood flow, supplying two thirds of liver blood flow, is not controlled directly by the liver; the fact that 20% of the cardiac output rushes through the most vascularized organ in the body, driven by a pressure gradient of only a few millimeters of mercury; the extremely distensible capacitance and venous resistance sites; the unidirectional acinar blood flow that regulates parenchymal cell metabolic specialization; and the high concentration of macrophagic (Kupffer) cells filtering the blood. The liver is the only organ reported to have regional blood flow monitored by the autonomic nervous system. This mechanism, when dysfunctional, accounts for the hepatorenal syndrome and offers a mechanistic therapeutic target to treat this syndrome. The trigger for liver regeneration is dependent on hepatic hemodynamics so that chronic liver blood flow regulates liver cell mass. In severe liver disease, the whole body circulation is reorganized, by forming portacaval shunts, to accommodate the increased intrahepatic venous resistance. These shunts protect the venous drainage of the splanchnic organs but lead to loss of major regulatory roles of the liver. The development of knowledge of the hepatic vasculature is presented from a historical perspective with modern concepts summarized based on the perspective of the author's four decades of devotion to this most marvelous of organs. Table of Contents: Acknowledgements / Historical Perspectives / Overview / Fluid Exchange / Capacitance / Resistance in the Hepatic Artery / Resistance in the Venous System / Fetal and Neonatal Hepatic Circulation / In Vivo Pharmacodynamic Approaches / Nitric Oxide / Adenosine / Hepatic Nerves / Hepatic Circulation and Toxicology / Hepatorenal Syndrome / Integrative Hepatic Response to Hemorrhage / Blood Flow Regulation of Hepatocyte Proliferation / Multiple Mechanisms Maintaining a Constant Hepatic Blood Flow to Liver Mass Ratio / Pathopharmacology and Repurposing Drugs as a Research Strategy / References
Author: Alix E. Harrow Publisher: Redhook ISBN: 0316421987 Category : Fiction Languages : en Pages : 373
Book Description
"A gorgeous, aching love letter to stories, storytellers, and the doors they lead us through...absolutely enchanting."—Christina Henry, bestselling author of Alice and Lost Boys LOS ANGELES TIMES BESTSELLER! Finalist for the 2020 Hugo, Nebula, Locus, and World Fantasy Awards. In the early 1900s, a young woman embarks on a fantastical journey of self-discovery after finding a mysterious book in this captivating and lyrical debut. In a sprawling mansion filled with peculiar treasures, January Scaller is a curiosity herself. As the ward of the wealthy Mr. Locke, she feels little different from the artifacts that decorate the halls: carefully maintained, largely ignored, and utterly out of place. Then she finds a strange book. A book that carries the scent of other worlds, and tells a tale of secret doors, of love, adventure, and danger. Each page turn reveals impossible truths about the world and January discovers a story increasingly entwined with her own. Lush and richly imagined, a tale of impossible journeys, unforgettable love, and the enduring power of stories await in Alix E. Harrow's spellbinding debut--step inside and discover its magic. Praise for The Ten Thousand Doors of January: "One for the favorites shelf... Here is a book to make you happy when you gently close it. Here you will find wonder and questions and an unceasingly gorgeous love of words which compasses even the shape a letter makes against a page."―NPR Books "Devastatingly good, a sharp, delicate nested tale of worlds within worlds, stories within stories, and the realm-cracking power of words."―Melissa Albert, New York Times bestselling author "A love letter to imagination, adventure, the written word, and the power of many kinds of love."―Kirkus For more from Alix E. Harrow, check out The Once and Future Witches.
Author: Andrew Norriss Publisher: Penguin UK ISBN: 014132158X Category : Fiction Languages : en Pages : 180
Book Description
William and his brother Daniel come home from school one day to find their parents have disappeared - It's the first of a series of shocks they have to cope with, not the least of which is finding that their house has been built over an inter-stellar portal - It's some time before they can solve the mystery of where their parents have gone and why - and in the meantime they have to cope with visiting aliens, chickens, and making their own lunch - It's not easy - Not easy at all.
Author: Dominik Parisien Publisher: Gallery / Saga Press ISBN: 9781481462358 Category : Fiction Languages : en Pages : 0
Book Description
Featured in the Netflix series Love, Death & Robots A unique anthology of all-new stories that challenges authors to throw down the gauntlet in an epic genre battle and demands an answer to the age-old question: Who is more awesome—robots or fairies? Rampaging robots! Tricksy fairies! Facing off for the first time in an epic genre death match! People love pitting two awesome things against each other. Robots vs. Fairies is an anthology that pitches genre against genre, science fiction against fantasy, through an epic battle of two icons. On one side, robots continue to be the classic sci-fi phenomenon in literature and media, from Asimov to WALL-E, from Philip K. Dick to Terminator. On the other, fairies are the beloved icons and unquestionable rulers of fantastic fiction, from Tinkerbell to Tam Lin, from True Blood to Once Upon a Time. Both have proven to be infinitely fun, flexible, and challenging. But when you pit them against each other, which side will triumph as the greatest genre symbol of all time? There can only be one…or can there? Featuring an incredible line-up of authors including John Scalzi, Catherynne M. Valente, Ken Liu, Max Gladstone, Alyssa Wong, Jonathan Maberry, and many more, Robots vs. Fairies will take you on a glitterbombed journey of a techno-fantasy mash-up across genres.
Author: Portal Games Publisher: ISBN: 9788360525463 Category : Board gamers Languages : en Pages : 266
Book Description
A group of the finest boardgame designers answered Ignacy Trzewiczek's invitation to take part in creating the book. They shared their anecdotes, tips and memoirs, making the book an unique trip over different designing styles, a formidable guide into the world of boardgame creation. Learn about process of design such games like Robinson Crusoe, Pathfinder, Hanabi, Neuroshima Hex and many other!--
Author: Darrel Dillon Publisher: Christian Faith Publishing, Inc. ISBN: 1098008251 Category : Fiction Languages : en Pages : 339
Book Description
Open Conflict continues from the previous Timelines story of David Mark as he shakes off the memories of an Earth gone immorally mad and searches for a better reality. His twin sister, Darla, is introduced to an unknown relative, Jenni. Together, they continue to follow David's alien space travels whenever they visit the Logos Station library. After the deciphering of the DTRIS file is complete, the alien implant is encased in a time capsule and buried on a distant planet. Through the DTRIS file story, you'll learn how events of Earth's past, present, and future connect to planned evil influence. An influence that persuades mortals to forsake their true heritage, and follow the path of least resistance. The same road that shortens mortal life and allows for the sacrifice of children to materialism or government abuse. There is a revelation concerning the actions of the Orzan, the Sangar, the Gulizors, VorCaveat, and other corrupted species. You'll also discover that time stands still during space travel through dark matter portals. The DTRIS File: Open Conflict is the second book in a compelling new science fiction saga. It continues the story of the happenings in the universe while Earth is going through a third world war. And if nothing else, you'll want to buy a talking cat from Dank Somber if you need a helpful companion.
Author: Tracey West Publisher: Scholastic ISBN: 9780439843645 Category : Children's stories Languages : en Pages : 74
Book Description
Link and his fairy guide, Navi, are journeying through Hyrule when they learn that an interdimensional portal has been opened and is sucking in anything and everything that gets near it!
Author: W. Wayne Lautt Publisher: Morgan & Claypool Publishers ISBN: 1615040099 Category : Science Languages : en Pages : 174
Book Description
The Hepatic circulation is unique among vascular beds. The most obvious unique features include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery (the hepatic arterial buffer response); the fact that portal blood flow, supplying two thirds of liver blood flow, is not controlled directly by the liver; the fact that 20% of the cardiac output rushes through the most vascularized organ in the body, driven by a pressure gradient of only a few millimeters of mercury; the extremely distensible capacitance and venous resistance sites; the unidirectional acinar blood flow that regulates parenchymal cell metabolic specialization; and the high concentration of macrophagic (Kupffer) cells filtering the blood. The liver is the only organ reported to have regional blood flow monitored by the autonomic nervous system. This mechanism, when dysfunctional, accounts for the hepatorenal syndrome and offers a mechanistic therapeutic target to treat this syndrome. The trigger for liver regeneration is dependent on hepatic hemodynamics so that chronic liver blood flow regulates liver cell mass. In severe liver disease, the whole body circulation is reorganized, by forming portacaval shunts, to accommodate the increased intrahepatic venous resistance. These shunts protect the venous drainage of the splanchnic organs but lead to loss of major regulatory roles of the liver. The development of knowledge of the hepatic vasculature is presented from a historical perspective with modern concepts summarized based on the perspective of the author's four decades of devotion to this most marvelous of organs. Table of Contents: Acknowledgements / Historical Perspectives / Overview / Fluid Exchange / Capacitance / Resistance in the Hepatic Artery / Resistance in the Venous System / Fetal and Neonatal Hepatic Circulation / In Vivo Pharmacodynamic Approaches / Nitric Oxide / Adenosine / Hepatic Nerves / Hepatic Circulation and Toxicology / Hepatorenal Syndrome / Integrative Hepatic Response to Hemorrhage / Blood Flow Regulation of Hepatocyte Proliferation / Multiple Mechanisms Maintaining a Constant Hepatic Blood Flow to Liver Mass Ratio / Pathopharmacology and Repurposing Drugs as a Research Strategy / References
Author: W. Wayne Lautt
Author: Alix E. Harrow
Author: Andrew Norriss
Author: Peter Darvill-Evans
Author: Dominik Parisien
Author: Jillian Scudder
Author: Portal Games
Author: Darrel Dillon
Author: Tracey West
Author: W. Wayne Lautt
Author: