Epithelial-mesenchymal Interactions in Development PDF Download

Author: Roger H. Sawyer
Publisher: Greenwood
ISBN:
Category : Science
Languages : en
Pages : 280

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Author: Itzhak D. Goldberg
Publisher: Birkhäuser
ISBN: 3034890702
Category : Science
Languages : en
Pages : 304

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Book Description
The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.

Author: Itzhak D. Goldberg
Publisher:
ISBN: 9783034890717
Category :
Languages : en
Pages : 316

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Author: Raul Fleischmajer
Publisher:
ISBN:
Category :
Languages : en
Pages : 326

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Author: Raul Fleischmajer
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: Betina Chandolia
Publisher:
ISBN: 9783659909221
Category :
Languages : en
Pages : 92

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Author: Sengel
Publisher: CUP Archive
ISBN: 9780521206440
Category : Medical
Languages : en
Pages : 296

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Author: Molly Weaver
Publisher:
ISBN:
Category : Cellular control mechanisms
Languages : en
Pages : 436

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Author: Raul Fleischmajer (ed)
Publisher:
ISBN:
Category : Epithelium
Languages : en
Pages : 348

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Author: 陳德華
Publisher: Open Dissertation Press
ISBN: 9781374731356
Category :
Languages : en
Pages :

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This dissertation, "Epithelial-mesenchymal Interactions in Development and Cytodifferentiation of Seminal Vesicle" by 陳德華, Tak-wah, Chan, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3121123 Subjects: Epithelium Mesenchyme Seminal vesicles