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Author: Michael A. Gorin Publisher: Springer ISBN: 3319923099 Category : Medical Languages : en Pages : 318
Book Description
Renal cell carcinoma (RCC) is the most common primary malignancy of the kidney, with an estimated 64,000 new cases diagnosed each year in the United States. Worldwide, this figure approaches 270,000 annual incident cases. At the time of initial presentation, 80% of patients with RCC will be diagnosed with a tumor localized the kidney. The majority of these lesions will be small (i.e. ≤4 cm) and potentially curable with either partial or radical nephrectomy. In recent decades, the rate of incidentally detected small renal tumors has risen substantially due the increasing use of cross-sectional imaging performed across the field of medicine. This rise in the incident number of localized renal tumors has unfortunately not resulted in a corresponding decrease in cases of metastatic RCC. This observation has led to our understanding that a significant proportion of incidentally detected renal tumors are of low malignant potential and may be safely managed with alternatives to surgery such active surveillance and thermo ablation. The use of these less invasive management approaches, however, must be balanced by the reality that upon spreading beyond the confines of the kidney, RCC is almost always incurable. Thus, when selecting a management strategy for a given patient, one must employ a risk-adapted approach that includes knowledge of a tumor’s histology and metastatic potential. In each patient, the goal of management should be to minimize the risk of progression to metastatic disease while preserving renal function and minimizing morbidity. This text provides a contemporary review of the diagnosis and surgical management of RCC. It opens with chapters on the pathology, radiology, and genetics of RCC. It then covers the risk stratification of renal tumors utilizing renal mass biopsy as well as non-invasive novel imaging-based scoring systems. Next, the surgical management of small and locally advanced renal tumors as well as the role of surgery in cases of metastatic RCC is reviewed. In addition, alternative approaches to surgery including active surveillance and ablative techniques are reviewed. Other chapters detail the emerging role of neoadjuvant and adjuvant systemic therapy in patients who are at high risk of progression to metastatic disease. Finally, the text covers the post-operative surveillance of patients with RCC as well as a summary of contemporary guidelines on the management of this disease. Diagnosis and Surgical Management of Renal Cell Carcinoma will serve as a comprehensive resource for physicians and researchers interested in RCC. All chapters will be written by experts in the field and will include the most up to date scientific and clinical information.
Author: Michael A. Gorin Publisher: Springer ISBN: 3319923099 Category : Medical Languages : en Pages : 318
Book Description
Renal cell carcinoma (RCC) is the most common primary malignancy of the kidney, with an estimated 64,000 new cases diagnosed each year in the United States. Worldwide, this figure approaches 270,000 annual incident cases. At the time of initial presentation, 80% of patients with RCC will be diagnosed with a tumor localized the kidney. The majority of these lesions will be small (i.e. ≤4 cm) and potentially curable with either partial or radical nephrectomy. In recent decades, the rate of incidentally detected small renal tumors has risen substantially due the increasing use of cross-sectional imaging performed across the field of medicine. This rise in the incident number of localized renal tumors has unfortunately not resulted in a corresponding decrease in cases of metastatic RCC. This observation has led to our understanding that a significant proportion of incidentally detected renal tumors are of low malignant potential and may be safely managed with alternatives to surgery such active surveillance and thermo ablation. The use of these less invasive management approaches, however, must be balanced by the reality that upon spreading beyond the confines of the kidney, RCC is almost always incurable. Thus, when selecting a management strategy for a given patient, one must employ a risk-adapted approach that includes knowledge of a tumor’s histology and metastatic potential. In each patient, the goal of management should be to minimize the risk of progression to metastatic disease while preserving renal function and minimizing morbidity. This text provides a contemporary review of the diagnosis and surgical management of RCC. It opens with chapters on the pathology, radiology, and genetics of RCC. It then covers the risk stratification of renal tumors utilizing renal mass biopsy as well as non-invasive novel imaging-based scoring systems. Next, the surgical management of small and locally advanced renal tumors as well as the role of surgery in cases of metastatic RCC is reviewed. In addition, alternative approaches to surgery including active surveillance and ablative techniques are reviewed. Other chapters detail the emerging role of neoadjuvant and adjuvant systemic therapy in patients who are at high risk of progression to metastatic disease. Finally, the text covers the post-operative surveillance of patients with RCC as well as a summary of contemporary guidelines on the management of this disease. Diagnosis and Surgical Management of Renal Cell Carcinoma will serve as a comprehensive resource for physicians and researchers interested in RCC. All chapters will be written by experts in the field and will include the most up to date scientific and clinical information.
Author: Juerg Hodler Publisher: Springer ISBN: 3319750194 Category : Medical Languages : en Pages : 262
Book Description
This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.
Author: Krishna Sasidharan Publisher: CRC Press ISBN: 0203089928 Category : Medical Languages : en Pages : 160
Book Description
Despite the rising popularity of the minimally invasive laparoscopic option, open nephron-sparing surgery is still seen by many experts as the 'gold standard' for open surgery for kidney tumors and should remain the first choice for many patients. This challenges the idea that less-invasive therapies are always more desirable than open surgery. Whi
Author: Philipp Dahm Publisher: John Wiley & Sons ISBN: 1119129885 Category : Medical Languages : en Pages : 614
Book Description
An updated and revised resource to evidence-based urology information and a guide for clinical practice The revised and updated second edition of Evidence-Based Urology offers the most current information on the suitability of both medical and surgical treatment options for a broad spectrum of urological conditions based on the best evidence available. The text covers each of the main urologic areas in specific sections such as general urology, oncology, female urology, trauma/reconstruction, pediatric urology, etc. All the evidence presented is rated for quality using the respected GRADE framework. Throughout the text, the authors highlight the most patient-important, clinical questions likely to be encountered by urologists in day-to-day practice. A key title in the “Evidence-Based” series, this revised and expanded edition of Evidence-Based Urology contains new chapters on a variety of topics including: quality improvement, seminoma, nonseminomatous germ cell tumor, penile cancer, medical prophylaxis, vesicoureteral reflux disease, cryptorchidism, prenatal hydronephrosis, and myelodysplasia. This updated resource: Offers a guide that centers on 100% evidence approach to medical and surgical approaches Provides practical recommendations for the care of individual patients Includes nine new chapters on the most recently trending topics Contains information for effective patient management regimes that are supported by evidence Puts the focus on the most important patient and clinical questions that are commonly encountered in day-to-day practice Written for urologists of all levels of practice, Evidence-Based Urology offers an invaluable treasure-trove of evidence-based information that is distilled into guidance for clinical practice.
Author: Kathy Pritchard-Jones Publisher: Springer ISBN: 9783662519189 Category : Medical Languages : en Pages : 0
Book Description
This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
Author: Primo N. Lara Publisher: Springer ISBN: 3319179039 Category : Medical Languages : en Pages : 400
Book Description
Kidney Cancer: Principles and Practice is a comprehensive and interdisciplinary textbook that encompasses all clinically relevant aspects of the disease. This new edition has been extensively updated and includes brand new material covering the most recent developments in kidney cancer diagnosis and therapy. The user-friendly and clinically oriented content of the book guarantees that it will be of great interest to a wide range of medical professionals, and every effort has been made to ensure that contributions are both easy to understand and directly related to patient care. Content presentation departs from the usual dense chapter format featuring a lengthy series of paragraphs. Instead, each chapter contains several boxed sections, including one that summarizes essential "take home points" for the busy clinician and another that presents a patient-oriented case highlighting the clinical application of elements discussed in that chapter. In addition, accessible original images, illustrations, and diagrams (some in full color) are used to simplify particularly complex material. This book will be of value for clinicians, researchers, residents, fellows, students, and knowledgeable lay people. The contributors comprise an international group of authors with expertise in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others.
Author: Mahul B. Amin Publisher: Lippincott Williams & Wilkins ISBN: 1469857960 Category : Medical Languages : en Pages : 2443
Book Description
Knowledge in the field of urologic pathology is growing at an explosive pace. Today’s pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology!
Author: Mototsugu Oya Publisher: Springer ISBN: 9784431566618 Category : Medical Languages : en Pages : 0
Book Description
This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.
Author: Michael A. Gorin
Author: Michael A. Gorin
Author: Juerg Hodler
Author: Krishna Sasidharan
Author: Philipp Dahm
Author: Kathy Pritchard-Jones
Author: Primo N. Lara
Author: Mahul B. Amin
Author: René Holzheimer
Author: Mototsugu Oya
Author: Maria Rosaria Raspollini