Development of Targeted Stealth Liposomes for Non-viral Gene Delivery PDF Download

Author: Alison Wedekind Tisdale
Publisher:
ISBN:
Category :
Languages : en
Pages : 58

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Author: Arabinda Chaudhuri
Publisher:
ISBN: 9781788015516
Category :
Languages : en
Pages : 300

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Book Description
Liposomal drug and gene delivery systems have found success in clinical applications due to their biodegradable, biocompatible, non-toxic, and non-immunogenic nature. To underscore their importance in healthcare, in the fight against SARS-CoV-2 virus, lipid-based nanoparticular formulations of mRNA and DNA based vaccines have been developed via academic and industry collaboration. Aimed at newcomers and established researchers alike, this book provides a comprehensive coverage of the field. Each chapter emphasizes design principles and concludes with highlighting unmet translational challenges. Topics covered include up-scaling liposome preparation, FDA approved liposomal drug delivery systems (LDDS) for cancer and non-cancerous diseases; liposomes in non-viral gene therapy; receptor selective LDDS for targeted cancer therapy; liposomal delivery of DNA and mRNA vaccines and liposomes for combination therapy. Whilst there are many review articles, this book brings together information and explains the complex science in an accessible manner.Written for an interdisciplinary audience, this book is an up-to-date resource for this important and vibrant research field.

Author: Mien-Chie Hung
Publisher: Elsevier
ISBN: 0080479774
Category : Science
Languages : en
Pages : 471

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Book Description
Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways.Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians.Key Features* Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine* Covers all types of nonviral vectors, from molecular structure to therapeutic applicationProvides a comprehensive review of synthetic vectors* Includes contributions from major investigators and leading experts in the field

Author: Suryakanta Swain
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659354526
Category :
Languages : en
Pages : 144

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Liposomes are found to be having passively targeted drug carrier to tumor cells because of its enhanced permeability and retention effect. Liposomes remain at the front of the drug delivery systems owing to its non-toxic, bio-degradable and non-immunogenic nature. It has been explored as carrier for delivery of drug molecules such as protein and peptides, genes, vaccines, genosomes, lipopolyplex, fusogenic liposomes and virsomes, etc. Stealth liposomes utilized for targeting hydrophilic anticancer drugs such as doxorubicin, mitoxantrone, etc. Still there is quest in developing drug delivery and drug targeting system utilizing liposomal formulations in the thrust area of cancer chemotherapy, antiviral, and such other biotechnological products.

Author: Hemani Varshik
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659484346
Category : Medical
Languages : en
Pages : 0

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Book Description
Cancer is a Major cause of death in today's fast changing world. Many recent developments involve in targeting Cancer cells without harming the normal celss. This book deals with Targeting Gemcitabine Containing Stealth (PEG Coated) Liposomes targeting Cancer cells. Breast Cancer cells are researched in this book. Cytotoxic and biodistribution studies are successfully carried out. Detailed methods of various preparations of liposomes are mentioned. Various characterization techniques like SEM and TEM are carried out and explained. Cytotoxic studies like cell line study is carried out on MCF-7 Cell line. Biodistribution distribution srudies are also carried successfully on Rats. This is one and half year core research from Parul Institute of Pharmacy, ACTREC (Advanced Center for Traetment, Research and Education on Cancer), Mumbai, Indian Institute of Technology, Powai and Sun Pharma Advanced research center, Vadodara. Author, Varshik Hemani, is also coming up with in-depth research on Wireless Drug Delivery System. This is current ongoing project at MIT, Boston, USA.

Author: Angel Catala
Publisher: BoD – Books on Demand
ISBN: 1789844940
Category : Science
Languages : en
Pages : 104

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Book Description
Liposomes have received increased attention in recent years. Nevertheless, liposomes, due to their various forms and applications, require further investigation. These structures can deliver both hydrophilic and hydrophobic drugs. The preparation of liposomes results in different properties for these systems. In addition, there are many factors and difficulties that affect the development of liposome drug delivery structures.The purpose of this book is to concentrate on recent developments in liposomes. The articles collected in this book are contributions by invited researchers with long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with a general background in many different biological sciences. This volume offers up-to-date, expert reviews of the fast-moving field of liposomes and is divided in two major sections: 1. Introduction; 2. Liposomes general properties

Author: Aleš Prokop
Publisher: Springer Science & Business Media
ISBN: 9400712480
Category : Science
Languages : en
Pages : 871

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Book Description
This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.

Author: M. A. Hayat
Publisher: Academic Press
ISBN: 0128094273
Category : Medical
Languages : en
Pages : 431

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Book Description
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. - Presents the most advanced information regarding the role of the autophagic system in life and death - Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both - Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation - Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment - Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Author: Warren C.W. Chan
Publisher: Springer
ISBN: 9780387767123
Category : Medical
Languages : en
Pages : 207

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Book Description
This edited book highlights the central players in the Bionanotechnology field - which are the nanostructures and biomolecules. It provides broad examples of current developments in Bionanotechnology research and is an excellent introduction to the field. The book describes how nanostructures are synthesized and details the wide variety of nanostructures available for biological research and applications. Examples of the unique properties of nanostructures are provided along with the current applications of these nanostructures in biology and medicine. The final chapters of the book describe the toxicity of nanostructures.

Author: D.D. Lasic
Publisher: Elsevier
ISBN: 0080536085
Category : Science
Languages : en
Pages : 795

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Book Description
The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 1960's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises. Following the original optimism in the 70's and early 80's, a period of severe skepticism ensued at the end of the 80's and beginning of the 90's, culminating in a moderate but real optimism in the mid 90's, as a result of a successful launch of the first products in the US and Europe.In this collection of papers, the editors have gathered the most promising ideas, approaches, applications and commercial developments, thereby presenting an up-to-date compilation of the present status of the field. This includes such broad areas as anti-cancer chemotherapy immune stimulation and infectious diseases. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such as DNA plasmids (genes), antisense oligonucleotides or ribozymes. Other future developments may be in topical delivery, vaccination and in diagnostics.Features of this book:• Contributions from almost all the leading labs in the field• Up-to-date, critical reviews bridged by editors' introductions• Organized into a logical framework.