Development of Low-Frequency Repetitive Transcranial Magnetic Stimulation as a Tool to Modulate Visual Disorders PDF Download

Author: Sara Rafique
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
Repetitive transcranial magnetic stimulation (rTMS) has become a popular neuromodulation technique, increasingly employed to manage several neurological and psychological conditions. Despite its popular use, the underlying mechanisms of rTMS remain largely unknown, particularly at the visual cortex. Moreover, the application of rTMS to modulate visual-related disorders is under-investigated. The goal of the present research was to address these issues. I employ a multitude of neuroimaging techniques to gain further insight into neural mechanisms underlying low-frequency (1 Hz) rTMS to the visual cortex. In addition, I begin to develop and refine clinical low-frequency rTMS protocols applicable to visual disorders as an alternative therapy where other treatment options are unsuccessful or where there are simply no existing therapies. One such visual disorder that can benefit from rTMS treatment is the perception of visual hallucinations that can occur following visual pathway damage in otherwise cognitively healthy individuals. In Chapters 23, I investigate the potential of multiday low-frequency rTMS to the visual cortex to alleviate continuous and disruptive visual hallucinations consequent to occipital injury. Combining rTMS with magnetic resonance imaging techniques reveals functional and structural cortical changes that lead to the perception of visual hallucinations; and rTMS successfully attenuates these anomalous visual perceptions. In Chapters 45, I compare the effects of alternative doses of low-frequency rTMS to the visual cortex on neurotransmitter levels and intrinsic functional connectivity to gain insight into rTMS mechanisms and establish the most effective protocol. Differential dose-dependent effects are observed on neurotransmitter levels and functional connectivity that suggest the choice of protocol critically depends on the neurophysiological target. Collectively, this work provides a basic framework for the use of low-frequency rTMS and neuroimaging in clinical application for visual disorders.

Author: Paul B Fitzgerald
Publisher: Springer Science & Business Media
ISBN: 3642364675
Category : Medical
Languages : en
Pages : 133

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Book Description
​Repetitive transcranial magnetic stimulation (rTMS) treatment is increasingly being used in the management of patients with depression. Nevertheless, considerable ignorance still exists about the treatment in general psychiatric practice. This concise clinical guide will serve as a reference and practical tool for clinicians working with or learning about this treatment technique. The opening chapters provide basic information on the history and development of rTMS treatment and its mechanism of action. Use of the treatment in depression is then addressed in detail, with explanation of the evidence base and discussion of a variety of clinical issues. Side-effects of treatment are explored, and careful consideration is given to the establishment of rTMS treatment programs and the training of clinicians. The final chapters will provide a brief overview of potential rTMS applications in other psychiatric conditions and some background on related treatments.

Author: Joshua Matthias Baruth
Publisher:
ISBN:
Category : Autism
Languages : en
Pages : 278

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Book Description
Evidence suggests that cortical minicolumns are reduced in size and increased in number in individuals with autism spectrum disorder (ASD), especially in the dorsolateral prefrontal cortex (DLPFC). More specifically minicolumns in individuals with ASD are narrower and contain less peripheral, neuropil space; this may cause an increase in the ratio of cortical excitation to inhibition and adversely affect the functional distinctiveness of minicolumnar activation. A lack of cortical inhibition may cause signal/sensory amplification which can impair functioning, raise physiological stress, and adversely affect social interaction in patients with ASD. Additionally, the DLPFC forms a circuit interconnected with many areas of cortex (e.g., anterior cingulate, orbitofrontal) and is involved in selecting a possible range of responses while suppressing inappropriate ones. Low-frequency (:'SlHz) repetitive transcranial magnetic stimulation (rTMS) has been shown to increase inhibition of stimulated cortex by the activation of inhibitory circuits. The baseline hypothesis was that individuals with ASD would show electroencephalopgrahic (EEG) and event-related potential (ERP) evidence of amplified cortical activity at early and late stages of visual processing as well as impaired indices of selective attention. The second hypothesis was that low-frequency rTMS would reduce augmented cortical responses at early stage and late stages of visual processing and improve selective attention and behavior in ASD. The baseline findings indicate both ERP and evoked gamma activity are amplified and indiscriminative in ASD at early stages of visual processing which may reflect decreased 'signal to noise' due to decreased cortical inhibitory processing. Additionally, individuals with ASD showed evidence of compromised selective attention, and had a significantly higher rate of motor response errors. After low-frequency rTMS individuals with ASD showed significant reductions in augmented ERP responses at very early stages of visual processing and showed significant improvement in discriminatory EEG gamma activity. There was also evidence of improved ERP indices of selective attention and significant reductions in irritability and repetitive behavior. TMS has the potential to become an important therapeutic tool in ASD treatment and has shown significant benefits in treating core symptoms of ASD with few, if any side effects.

Author: Richard A. Bermudes, M.D.
Publisher: American Psychiatric Pub
ISBN: 1615371052
Category : Medical
Languages : en
Pages : 240

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Book Description
Edited by clinicians who were involved with transcranial magnetic stimulation (TMS) from the beginning, Transcranial Magnetic Stimulation: Clinical Applications for Psychiatric Practice offers everything the mental health practitioner needs to know about this innovative and well-established treatment. It is increasingly clear that different combinations of biological, neurobehavioral, and symptomatic factors contribute to the problem of "treatment resistance" in psychiatric disorders. Fortunately, a number of neuromodulation approaches, including TMS, are providing more options for clinicians to combat psychiatric problems. However, guidance about how to identify patients who are good candidates for TMS and how to comanage them during treatment is scarce because instruction on this modality has yet to be integrated into most psychiatry residencies. Thus, this text fills a great need, providing clinicians with an evidence-based foundation for the efficacy and safety of TMS. Despite the rapid growth of this innovative option, many practitioners are unclear about how best to utilize TMS. The book addresses these clinical concerns systematically and thoroughly: - Clinical vignettes illustrate how to identify appropriate patients for referral to a TMS clinician. - Discussions of treatment resistance, psychiatric and medical comorbidities, and preparation of the patient for TMS are included. - Because TMS is likely to be used concurrently with other treatments, the book explains how to best integrate this modality with psychotherapy, pharmacotherapy, and other forms of neuromodulation to improve outcomes. - In-depth coverage is provided on how to coordinate efforts between the primary treatment and TMS teams to assure the best outcomes during acute, continuation, and maintenance treatment. - Chapters provide a review of topic-specific literature, as well as clinical vignettes that highlight how to integrate TMS into patient care. - Key clinical points summarize the optimal clinical application of TMS for the general mental health provider. - The evolving nature of TMS research, such as the ongoing development of this and related technologies, as well as its expanding use as a potential treatment for other clinical neuropsychiatric conditions, is also addressed. Transcranial Magnetic Stimulation: Clinical Applications for Psychiatric Practice guides the general psychiatrist and mental health clinician on how to integrate this treatment modality into their practice by presenting an update on the current clinical role of TMS and a road map to its potential future.

Author: Paul E. Holtzheimer
Publisher: Oxford University Press, USA
ISBN: 0199926484
Category : Medical
Languages : en
Pages : 194

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Book Description
The Clinical Guide serves as a reference tool for clinicians in the administration of transcranial magnetic stimulation (TMS) for neuropsychiatric disorders. The primary intent of this Guide is to focus on the clinical applications of TMS and to offer detailed information on the safe and effective administration of TMS with consideration of the neurophysiological effects particularly in relation to safety, targeting specific cortical areas and practical issues such as the length of treatment sessions and the durability of the TMS response. The Guide focuses on the evidenced based literature and utilizes this literature to inform specific recommendations on the use of rTMS in a clinical setting. The efficacy and safety of TMS for neuropsychiatric disorders, including its use in special populations, such as the elderly, will be reviewed to facilitate clinical decision-making. The Guide will also outline setting up a TMS service including practical issues such as considerations for the qualifications of the person administering the treatment, the use of concomitant medications, what equipment is necessary to have in the treatment room and monitoring the outcomes to treatment. The Guide is intended to be a practical reference for the practicing clinician in the safe and effective administration of TMS.

Author: Mark Hallett
Publisher: Elsevier Health Sciences
ISBN: 0750673737
Category : Medical
Languages : en
Pages : 476

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Book Description
Covers the diagnostic and clinical applications of transcranial magnetic stimulation (TMS) and offers cutting-edge, in-depth guidance on the use of TMS to study brain physiology and pathophysiology as well as its current and future therapeutic uses. Readers will find the essential up-to-date information they need to make the most of this dynamic method. Delivers a detailed analysis of the physics of magnetic stimulation as well as basic mechanisms of how magnetic stimulation activates neural tissue. Presents expert guidance on the clinical uses of TMS as well as its therapeutic and research applications.

Author: Eric Wassermann
Publisher: Oxford University Press
ISBN: 0198568924
Category : Medical
Languages : en
Pages : 773

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Book Description
Transcranial stimulation comprises an important set of techniques for investigating brain function, some of which promise to treat diseases. This book provides a review of the scientific and technical background required to understand transcranial stimulation, for neuroscientists, neurologists, and psychiatrists.

Author: Mark S. George
Publisher: American Psychiatric Pub
ISBN: 1585626376
Category : Medical
Languages : en
Pages : 302

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Book Description
As understanding evolves about how different brain regions are involved in carrying out everyday tasks -- and in causing brain diseases when they go awry -- this book describes a new technology that allows physicians to focally stimulate the brain in awake adults through a non-invasive procedure. Transcranial Magnetic Stimulation in Clinical Psychiatry is an accessible and authoritative review of TMS, a procedure that is showing promise as a treatment in several disorders. Its authors explain how the procedure works, then the latest findings in a wide range of situations -- notably in depression, but also in other conditions ranging from migraine to stroke recovery. This concise overview of TMS offers practical guidance for psychiatrists and other clinicians using it as a therapy, or referring their patients to have this done, as well as updating the field for neuroscientists and neurologists. It begins with background on the physics and safety of TMS, a guide for administering the procedure, and a review of basic neurophysiological studies with TMS, showing how it can be used to measure connectivity and excitability of the cerebral cortex. The heart of book is then devoted to its clinical applications, organized by disorder: Epilepsy, movement disorders, and pain -- describes the use of TMS in inducing and inhibiting seizures and investigating their pathophysiology; in treating Parkinson's disease; and in relieving pain through motor cortex stimulation Major depression -- provides a critical review of research in the most-studied clinical application of TMS in psychiatry, where it is used as a therapeutic intervention and a neurophysiological probe Mania -- explores the effectiveness of TMS in light of its ECT-like properties through a trial of right TMS vs. sham TMS Anxiety disorders -- reports on investigations on the uses of TMS in treating obsessive-compulsive disorder and posttraumatic stress disorder Schizophrenia -- reviews studies utilizing single- or paired-pulse TMS to assess cortical inhibition and those that explore effects of extended trains of repetitive TMS in altering symptoms A further chapter on TMS in brain imaging shows how integrating imaging and TMS allows one to better place the TMS coil, better understand TMS effects on the brain, and improve understanding of how the brain mediates behavior. With a concluding overview of prospects for the future of repetitive TMS, this volume offers a definitive look at this cutting-edge research and provides critical guidance on how and when clinicians might use TMS in their practice.

Author: Matthew Tull
Publisher: Academic Press
ISBN: 0128162899
Category : Psychology
Languages : en
Pages : 654

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Book Description
Emotion in Posttraumatic Stress Disorder provides an up-to-date review of the empirical research on the relevance of emotions, such as fear, anxiety, shame, guilt, and disgust to posttraumatic stress disorder (PTSD). It also covers emerging research on the psychophysiology and neurobiological underpinnings of emotion in PTSD, as well as the role of emotion in the behavioral, cognitive, and affective difficulties experienced by individuals with PTSD. It concludes with a review of evidence-based treatment approaches for PTSD and their ability to mitigate emotion dysfunction in PTSD, including prolonged exposure, cognitive processing therapy, and acceptance-based behavioral therapy. - Identifies how emotions are central to understanding PTSD. - Explore the neurobiology of emotion in PTSD. - Discusses emotion-related difficulties in relation to PTSD, such as impulsivity and emotion dysregulation. - Provides a review of evidence-based PTSD treatments that focus on emotion.

Author: Manuel F. Casanova
Publisher: Nova Publishers
ISBN: 9781594544972
Category : Education
Languages : en
Pages : 234

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Book Description
Autism is a condition worn for public scrutiny, blending personal aspects of the patient's life with his/her social environment. This book focuses on the physical aspects which make an individual autistic.