Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description

Author: Richard A. Ward
Publisher: Royal Society of Chemistry
ISBN: 1849731748
Category : Medical
Languages : en
Pages : 333

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Book Description
Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development. Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and identifies a number of hot topics and key areas for kinase drug discovery over the coming years. It includes contributions from highly respected authors with a combined experience in the industry of well over 200 years, which has resulted in a book of great interest to the kinase field and across drug discovery more generally. Readers will gain a real insight into the huge challenges and opportunities which this target class has presented drug discovery scientists. The many chapters cover a wide breadth of topics, are well written and include high quality colour and black and white images. Topics covered include an outline of how medicinal chemistry has been able to specifically exploit this unique target class, along with reflections on the mechanisms of kinases inhibitors. Also covered is resistance to kinase inhibitors caused by amino acid mutations, case studies of kinase programs and reviews areas beyond protein kinases and beyond the human kinome. Also described are modern approaches to finding kinase leads and the book finishes with a reflection of how kinase drug discovery may progress over the coming years.

Author: N. Anand
Publisher: Elsevier
ISBN: 0080527523
Category : Medical
Languages : en
Pages : 525

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Book Description
This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Author: Wendy A. Warr
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 292

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Book Description

Author: Satya Prakash Gupta
Publisher: Academic Press
ISBN: 0128096829
Category : Science
Languages : en
Pages : 518

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Book Description
Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

Author: Roger G. Finch
Publisher:
ISBN: 9780443071294
Category : Medical
Languages : en
Pages : 0

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Book Description
The completely revised and updated New Edition of this respected resource presents globally-relevant coverage of all types of antimicrobial agents used in human medicine, providing authoritative guidance on the principles and practice of antimicrobial chemotherapy. In addition to full coverage of every commonly used antibiotic agent, it includes complete coverage of all antiviral, antiprotozoan and anthelminthic agents. And, its unique 3-part structure makes it easy to locate information: Part I covers general aspects of treatment; Part II reviews every agent, including antimicrobial activity, pharmacokinetics, clinical use, and available preparations; Part III details the treatment of particular infections. Discusses the increasing problem of multi-drug resistance and the wide range of new antiviral therapies now available for the treatment of HIV and other viral infections. Reviews all of the new antimicrobial agents in detail. Features more clinically focused sections on Pharmacokinetics. Details new antifungal therapies, including voriconazole, liposomal, and amphotericin B. Presents new tables on major drug interactions, placental transfer, and concentrations of agents in breast milk. Features new sections on liver failure, drug development and licensing, and the implications of xenotransplantation. Presents expanded coverage of Quinolone as well as new antimalarial combination therapies. Offers cross-references to key web sites, for up-to-date information on treatment and drug resistance.

Author: W. Richard Webb
Publisher: Lippincott Williams & Wilkins
ISBN: 1605479764
Category : Medical
Languages : en
Pages : 940

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Book Description
Written by two of the world's most respected specialists in thoracic imaging, this volume is the most comprehensive text-reference to address imaging of the heart and lungs. This edition has a new full-color design and many full-color images, including PET-CT.

Author: R. Eric Miller
Publisher: Elsevier Health Sciences
ISBN: 1455773999
Category : Medical
Languages : en
Pages : 793

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Book Description
Logically organized by taxonomic groups, this up-to-date text covers the diagnosis and treatment of all zoo animal species and free-ranging wildlife, including amphibians, reptiles, birds, mammals, and fish, unlikely to be seen by private practice veterinarians. Featuring full-color images, the consistent, user-friendly format supplies information on each animal's biology, unique anatomy, special physiology, reproduction, restraint and handling, housing requirements, nutrition and feeding, surgery and anesthesia, diagnostics, therapeutics, and diseases. Global authorship includes multinational contributors who offer expert information on different species from around the world. "This is a welcome update to an invaluable reference series; a must-have for any veterinary professional working largely in the zoo or wildlife field, and also recommended as a reference text for the library of any practice seeing unusual species on a regular basis, even if they already have an earlier volume."Reviewed by: Charlotte Day on behalf of The Veterinary Record, Oct 14 - Global authorship includes internationally recognized authors who have contributed new chapters focusing on the latest research and clinical management of captive and free-ranging wild animals from around the world. - Zoological Information Management System chapter offers the latest update on this brand new system that contains a worldwide wealth of information. - General taxonomy-based format provides a comprehensive text for sharing information in zoo and wildlife medicine. - Concise tables provide quick reference to key points in the references. - NEW! All new authors have completely revised the content to provide fresh perspectives from leading experts in the field on the latest advances in zoo and wild animal medicine. - NEW! Color images vividly depict external clinical signs for more accurate recognition and diagnosis.

Author: Sebastian Hensel
Publisher:
ISBN:
Category :
Languages : en
Pages : 398

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Book Description

Author: Vintner
Publisher: CRC Press
ISBN: 9780849377723
Category : Medical
Languages : en
Pages : 468

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Book Description
This book provides a myriad of fresh ideas and energetic approaches to the newer aspects of everyday drug modelling. With contributions from some of the best young talents of today, Molecular Modelling and Drug Design encourages a break from old traditions and probes the unexplored avenues of the modelling tool. The contributors' views act as a gauge to future trends in computer-aided drug design-an area that continues to expand and play an ever more significant role in drug discovery.