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Author: Heinz Koeppl Publisher: Springer Science & Business Media ISBN: 1441967664 Category : Technology & Engineering Languages : en Pages : 407
Book Description
The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.
Author: Heinz Koeppl Publisher: Springer Science & Business Media ISBN: 1441967664 Category : Technology & Engineering Languages : en Pages : 407
Book Description
The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.
Author: Domitilla Del Vecchio Publisher: Princeton University Press ISBN: 1400850509 Category : Science Languages : en Pages : 287
Book Description
This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources. Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems. Provides a user-friendly introduction to essential concepts, tools, and applications Covers the most commonly used modeling methods Addresses the modular design problem for biomolecular systems Uses design examples from both natural systems and synthetic circuits Solutions manual (available only to professors at press.princeton.edu) An online illustration package is available to professors at press.princeton.edu
Author: Chris J. Myers Publisher: CRC Press ISBN: 1420083252 Category : Medical Languages : en Pages : 302
Book Description
This text presents the modeling, analysis, and design methods for systems biology. It discusses how to examine experimental data to learn about mathematical models, develop efficient abstraction and simulation methods to analyze these models, and use analytical methods to design new circuits. The author reviews basic molecular biology and biochemistry principles, covers several methods for modeling and analyzing genetic circuits, and uses phage lambda as an example throughout to help illustrate the methods. He also explores the emerging area of synthetic biology. iBioSim software, lecture slides, and a password-protected solutions manual are available on the author's website.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309219396 Category : Science Languages : en Pages : 570
Book Description
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Author: Vikram Singh Publisher: Springer ISBN: 9401795142 Category : Science Languages : en Pages : 383
Book Description
This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.
Author: Luca Aceto Publisher: Springer ISBN: 3319631217 Category : Computers Languages : en Pages : 666
Book Description
This Festschrift is published in honor of Kim Guldstrand Larsen, one of the earliest precursors of computer science in Denmark, on the occasion of his 60th birthday. During the last three decades, Kim Guldstrand Larsen has given major contributions across a remarkably wide range of topics, including real-time, concurrent, and probabilistic models of computation, logic in computer science, and model checking. Since 1995, he has been one of the prime movers behind the model checking tool for real-time systems UPPAAL, for which he was a co-recipient of the CAV Award in 2013. The Festschrift contains 32 papers that feature the broad range of Kim Guldstrand Larsen's research topics, such as formal languages and automata theory; logic; verification, model checking and testing; algorithmic game theory and mechanism design; semantics and reasoning; real-time and distributed systems; and modeling and simulation.
Author: Alessandro Abate Publisher: Springer Nature ISBN: 3030851729 Category : Computers Languages : en Pages : 469
Book Description
This book constitutes the proceedings of the 18th International Conference on Quantitative Evaluation Systems, QEST 2021, held in Paris, France, in August 2021. The 21 full papers and 2 short papers presented together with 2 keynote papers were carefully reviewed and selected from 47 submissions. The papers are organized in the following topics: probabilistic model checking; quantitative models and metamodels: analysis and validation; queueing systems; learning and verification; simulation; performance evaluation; abstractions and aggregations; and stochastic models.
Author: Tengfei Liu Publisher: CRC Press ISBN: 1466584602 Category : Technology & Engineering Languages : en Pages : 345
Book Description
Significant progress has been made on nonlinear control systems in the past two decades. However, many of the existing nonlinear control methods cannot be readily used to cope with communication and networking issues without nontrivial modifications. For example, small quantization errors may cause the performance of a "well-designed" nonlinear control system to deteriorate. Motivated by the need for new tools to solve complex problems resulting from smart power grids, biological processes, distributed computing networks, transportation networks, robotic systems, and other cutting-edge control applications, Nonlinear Control of Dynamic Networks tackles newly arising theoretical and real-world challenges for stability analysis and control design, including nonlinearity, dimensionality, uncertainty, and information constraints as well as behaviors stemming from quantization, data-sampling, and impulses. Delivering a systematic review of the nonlinear small-gain theorems, the text: Supplies novel cyclic-small-gain theorems for large-scale nonlinear dynamic networks Offers a cyclic-small-gain framework for nonlinear control with static or dynamic quantization Contains a combination of cyclic-small-gain and set-valued map designs for robust control of nonlinear uncertain systems subject to sensor noise Presents a cyclic-small-gain result in directed graphs and distributed control of nonlinear multi-agent systems with fixed or dynamically changing topology Based on the authors’ recent research, Nonlinear Control of Dynamic Networks provides a unified framework for robust, quantized, and distributed control under information constraints. Suggesting avenues for further exploration, the book encourages readers to take into consideration more communication and networking issues in control designs to better handle the arising challenges.
Author: Heinz Koeppl
Author: Heinz Koeppl
Author: Domitilla Del Vecchio
Author: Chris J. Myers
Author: Heinz Koeppl
Author: Institute of Medicine
Author: Benno Müller-Hill
Author: Vikram Singh
Author: Luca Aceto
Author: Alessandro Abate
Author: Tengfei Liu