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Author: Necibe Tuncer Publisher: World Scientific Publishing Company ISBN: 9789811263026 Category : Mathematics Languages : en Pages : 0
Book Description
This book is a collection of works that represent the recent advancements in computational and mathematical methods applied to population dynamics. It concentrates on both development of new tools as well as on innovative use of existing tools to obtain new understanding of biological systems. The volume introduces new state-of-the-art techniques for defining and solving numerically control problems in mathematical biology in which the control appears linearly. Such problems produce simpler optimal controls that can be implemented in practice. The book further develops tools for fitting multi-scale models to multi-scale data and studying the practical identifiability of the parameters from multi-scale data. Novel model of Zika with Wolbahia infection in mosquitoes suggests that the most suitable control strategy to control Zika in the absence of Wolbahia is killing mosquitoes but the most suitable strategy when mosquitoes are Wolbahia infected is the treatment of humans.A completely novel methodology of developing discrete-continuous hybrid models of multi-species interactions is also introduced together with avantgarde techniques for discrete-continuous hybrid models analysis. A mathematical model leads to new observations of the within-host virus dynamics and its interplay with the immune responses. In particular, it is observed that the parameters promoting CTL responses need to be boosted over parameters promoting antibody production to obtain a biologically relevant steady state. A novel stochastic model of COVID-19 investigates quarantine and lock down as important strategies for control and elimination of COVID-19.
Author: Necibe Tuncer Publisher: World Scientific Publishing Company ISBN: 9789811263026 Category : Mathematics Languages : en Pages : 0
Book Description
This book is a collection of works that represent the recent advancements in computational and mathematical methods applied to population dynamics. It concentrates on both development of new tools as well as on innovative use of existing tools to obtain new understanding of biological systems. The volume introduces new state-of-the-art techniques for defining and solving numerically control problems in mathematical biology in which the control appears linearly. Such problems produce simpler optimal controls that can be implemented in practice. The book further develops tools for fitting multi-scale models to multi-scale data and studying the practical identifiability of the parameters from multi-scale data. Novel model of Zika with Wolbahia infection in mosquitoes suggests that the most suitable control strategy to control Zika in the absence of Wolbahia is killing mosquitoes but the most suitable strategy when mosquitoes are Wolbahia infected is the treatment of humans.A completely novel methodology of developing discrete-continuous hybrid models of multi-species interactions is also introduced together with avantgarde techniques for discrete-continuous hybrid models analysis. A mathematical model leads to new observations of the within-host virus dynamics and its interplay with the immune responses. In particular, it is observed that the parameters promoting CTL responses need to be boosted over parameters promoting antibody production to obtain a biologically relevant steady state. A novel stochastic model of COVID-19 investigates quarantine and lock down as important strategies for control and elimination of COVID-19.
Author: Horst R. Thieme Publisher: Princeton University Press ISBN: 0691187657 Category : Science Languages : en Pages : 564
Book Description
The formulation, analysis, and re-evaluation of mathematical models in population biology has become a valuable source of insight to mathematicians and biologists alike. This book presents an overview and selected sample of these results and ideas, organized by biological theme rather than mathematical concept, with an emphasis on helping the reader develop appropriate modeling skills through use of well-chosen and varied examples. Part I starts with unstructured single species population models, particularly in the framework of continuous time models, then adding the most rudimentary stage structure with variable stage duration. The theme of stage structure in an age-dependent context is developed in Part II, covering demographic concepts, such as life expectation and variance of life length, and their dynamic consequences. In Part III, the author considers the dynamic interplay of host and parasite populations, i.e., the epidemics and endemics of infectious diseases. The theme of stage structure continues here in the analysis of different stages of infection and of age-structure that is instrumental in optimizing vaccination strategies. Each section concludes with exercises, some with solutions, and suggestions for further study. The level of mathematics is relatively modest; a "toolbox" provides a summary of required results in differential equations, integration, and integral equations. In addition, a selection of Maple worksheets is provided. The book provides an authoritative tour through a dazzling ensemble of topics and is both an ideal introduction to the subject and reference for researchers.
Author: Necibe Tuncer Publisher: World Scientific ISBN: 9811263043 Category : Mathematics Languages : en Pages : 470
Book Description
This book is a collection of works that represent the recent advancements in computational and mathematical methods applied to population dynamics. It concentrates on both development of new tools as well as on innovative use of existing tools to obtain new understanding of biological systems. The volume introduces new state-of-the-art techniques for defining and solving numerically control problems in mathematical biology in which the control appears linearly. Such problems produce simpler optimal controls that can be implemented in practice. The book further develops tools for fitting multi-scale models to multi-scale data and studying the practical identifiability of the parameters from multi-scale data. Novel model of Zika with Wolbahia infection in mosquitoes suggests that the most suitable control strategy to control Zika in the absence of Wolbahia is killing mosquitoes but the most suitable strategy when mosquitoes are Wolbahia infected is the treatment of humans.A completely novel methodology of developing discrete-continuous hybrid models of multi-species interactions is also introduced together with avantgarde techniques for discrete-continuous hybrid models analysis. A mathematical model leads to new observations of the within-host virus dynamics and its interplay with the immune responses. In particular, it is observed that the parameters promoting CTL responses need to be boosted over parameters promoting antibody production to obtain a biologically relevant steady state. A novel stochastic model of COVID-19 investigates quarantine and lock down as important strategies for control and elimination of COVID-19.
Author: Mimmo Iannelli Publisher: Springer ISBN: 3319030264 Category : Mathematics Languages : en Pages : 351
Book Description
This book is an introduction to mathematical biology for students with no experience in biology, but who have some mathematical background. The work is focused on population dynamics and ecology, following a tradition that goes back to Lotka and Volterra, and includes a part devoted to the spread of infectious diseases, a field where mathematical modeling is extremely popular. These themes are used as the area where to understand different types of mathematical modeling and the possible meaning of qualitative agreement of modeling with data. The book also includes a collections of problems designed to approach more advanced questions. This material has been used in the courses at the University of Trento, directed at students in their fourth year of studies in Mathematics. It can also be used as a reference as it provides up-to-date developments in several areas.
Author: Dominik Wodarz Publisher: Springer Science & Business Media ISBN: 0387687335 Category : Mathematics Languages : en Pages : 226
Book Description
This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.
Author: Richard Haberman Publisher: SIAM ISBN: 0898714087 Category : Mathematics Languages : en Pages : 412
Book Description
The author uses mathematical techniques to give an in-depth look at models for mechanical vibrations, population dynamics, and traffic flow.
Author: Nicolas Bacaër Publisher: Springer Science & Business Media ISBN: 0857291157 Category : Mathematics Languages : en Pages : 160
Book Description
As Eugene Wigner stressed, mathematics has proven unreasonably effective in the physical sciences and their technological applications. The role of mathematics in the biological, medical and social sciences has been much more modest but has recently grown thanks to the simulation capacity offered by modern computers. This book traces the history of population dynamics---a theoretical subject closely connected to genetics, ecology, epidemiology and demography---where mathematics has brought significant insights. It presents an overview of the genesis of several important themes: exponential growth, from Euler and Malthus to the Chinese one-child policy; the development of stochastic models, from Mendel's laws and the question of extinction of family names to percolation theory for the spread of epidemics, and chaotic populations, where determinism and randomness intertwine. The reader of this book will see, from a different perspective, the problems that scientists face when governments ask for reliable predictions to help control epidemics (AIDS, SARS, swine flu), manage renewable resources (fishing quotas, spread of genetically modified organisms) or anticipate demographic evolutions such as aging.
Author: S. Anita Publisher: Springer Science & Business Media ISBN: 9780792366393 Category : Mathematics Languages : en Pages : 220
Book Description
This volume is devoted to some of the most biologically significant control problems governed by continuous age-dependent population dynamics. It investigates the existence, uniqueness, positivity, and asymptotic behaviour of the solutions of the continuous age-structured models. Some comparison results are also established. In the optimal control problems the emphasis is on first order necessary conditions of optimality. These conditions allow the determination of the optimal control or the approximation of the optimal control problem. The exact controllability for some models with diffusion and internal control is also studied. These subjects are treated using new concepts and techniques of modern optimal control theory, such as Clarke's generalized gradient, Ekeland's variational principle, Hamilton-Jacobi equations, and Carleman estimates. A background in advanced calculus and partial differential equations is required. Audience: This work will be of interest to students in mathematics, biology, and engineering, and researchers in applied mathematics, control theory, and biology.
Author: Shripad Tuljapurkar Publisher: Springer Science & Business Media ISBN: 3642516521 Category : Mathematics Languages : en Pages : 148
Book Description
Demography relates observable facts about individuals to the dynamics of populations. If the dynamics are linear and do not change over time, the classical theory of Lotka (1907) and Leslie (1945) is the central tool of demography. This book addresses the situation when the assumption of constancy is dropped. In many practical situations, a population will display unpredictable variation over time in its vital rates, which must then be described in statistical terms. Most of this book is concerned with the theory of populations which are subject to random temporal changes in their vital rates, although other kinds of variation (e. g. , cyclical) are also dealt with. The central questions are: how does temporal variation work its way into a population's future, and how does it affect our interpretation of a population's past. The results here are directed at demographers of humans and at popula tion biologists. The uneven mathematical level is dictated by the material, but the book should be accessible to readers interested in population the ory. (Readers looking for background or prerequisites will find much of it in Hal Caswell's Matrix population models: construction, analysis, and in terpretation (Sinauer 1989) ). This book is in essence a progress report and is deliberately brief; I hope that it is not mystifying. I have not attempted to be complete about either the history or the subject, although most sig nificant results and methods are presented.
Author: K. Gopalsamy Publisher: Springer Science & Business Media ISBN: 9780792315940 Category : Mathematics Languages : en Pages : 526
Book Description
This monograph provides a definitive overview of recent advances in the stability and oscillation of autonomous delay differential equations. Topics include linear and nonlinear delay and integrodifferential equations, which have potential applications to both biological and physical dynamic processes. Chapter 1 deals with an analysis of the dynamical characteristics of the delay logistic equation, and a number of techniques and results relating to stability, oscillation and comparison of scalar delay and integrodifferential equations are presented. Chapter 2 provides a tutorial-style introduction to the study of delay-induced Hopf bifurcation to periodicity and the related computations for the analysis of the stability of bifurcating periodic solutions. Chapter 3 is devoted to local analyses of nonlinear model systems and discusses many methods applicable to linear equations and their perturbations. Chapter 4 considers global convergence to equilibrium states of nonlinear systems, and includes oscillations of nonlinear systems about their equilibria. Qualitative analyses of both competitive and cooperative systems with time delays feature in both Chapters 3 and 4. Finally, Chapter 5 deals with recent developments in models of neutral differential equations and their applications to population dynamics. Each chapter concludes with a number of exercises and the overall exposition recommends this volume as a good supplementary text for graduate courses. For mathematicians whose work involves functional differential equations, and whose interest extends beyond the boundaries of linear stability analysis.
Author: Necibe Tuncer
Author: Necibe Tuncer
Author: Horst R. Thieme
Author: Necibe Tuncer
Author: Mimmo Iannelli
Author: Dominik Wodarz
Author: Richard Haberman
Author: Nicolas Bacaër
Author: S. Anita
Author: Shripad Tuljapurkar
Author: K. Gopalsamy