The Republic of Yemen PDF Download

Author: Marta Colburn
Publisher: CIIR
ISBN: 9781852872496
Category : Yemen
Languages : en
Pages : 92

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Author: Thomas, J. Joshua
Publisher: IGI Global
ISBN: 1799811948
Category : Computers
Languages : en
Pages : 355

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Book Description
Many approaches have sprouted from artificial intelligence (AI) and produced major breakthroughs in the computer science and engineering industries. Deep learning is a method that is transforming the world of data and analytics. Optimization of this new approach is still unclear, however, and there’s a need for research on the various applications and techniques of deep learning in the field of computing. Deep Learning Techniques and Optimization Strategies in Big Data Analytics is a collection of innovative research on the methods and applications of deep learning strategies in the fields of computer science and information systems. While highlighting topics including data integration, computational modeling, and scheduling systems, this book is ideally designed for engineers, IT specialists, data analysts, data scientists, engineers, researchers, academicians, and students seeking current research on deep learning methods and its application in the digital industry.

Author: Hoai An Le Thi
Publisher: Springer
ISBN: 3030218031
Category : Technology & Engineering
Languages : en
Pages : 1164

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Book Description
This book contains 112 papers selected from about 250 submissions to the 6th World Congress on Global Optimization (WCGO 2019) which takes place on July 8–10, 2019 at University of Lorraine, Metz, France. The book covers both theoretical and algorithmic aspects of Nonconvex Optimization, as well as its applications to modeling and solving decision problems in various domains. It is composed of 10 parts, each of them deals with either the theory and/or methods in a branch of optimization such as Continuous optimization, DC Programming and DCA, Discrete optimization & Network optimization, Multiobjective programming, Optimization under uncertainty, or models and optimization methods in a specific application area including Data science, Economics & Finance, Energy & Water management, Engineering systems, Transportation, Logistics, Resource allocation & Production management. The researchers and practitioners working in Nonconvex Optimization and several application areas can find here many inspiring ideas and useful tools & techniques for their works.

Author: Flavio Tangianu
Publisher: Springer Nature
ISBN: 303078021X
Category : Medical
Languages : en
Pages : 332

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Book Description
This book assesses the main features of COVID-19 from a clinical point of view, based on observations made during the disease epidemic in Northern Italy, one of the most affected areas in the world (the region has been the epicenter of the global pandemic for more than a month), and the first region outside China facing overwhelming numbers of cases. With no practical guidelines in place, Italian doctors were called to fight against an unknown disease. For the first time in modern history, healthcare workers and decision-makers had to find rapid solutions to a life-changing health crisis with no evidence-based recommendations or procedures in place to guide their actions. Sharing the lessons learned from this experience, and offering practical tips on implementing future programs for pandemic preparedness, the book is a valuable tool for medical practitioners and health-policy-makers wanting to better understand the complexity of the current and future global health crises.

Author: Huixiao Hong
Publisher: Springer
ISBN: 3030164438
Category : Science
Languages : en
Pages : 416

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Book Description
This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based approaches for the assessment of drug toxicity and toxicogenomic analyses. Offering a valuable reference guide to computational toxicology and potential applications in regulatory science, this book will appeal to chemists, toxicologists, drug discovery and development researchers as well as to regulatory scientists, government reviewers and graduate students interested in this field.

Author: Li Di
Publisher: John Wiley & Sons
ISBN: 1118788354
Category : Medical
Languages : en
Pages : 604

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Book Description
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Author: Olga Martin-Ortega
Publisher:
ISBN: 9781788116305
Category : Government purchasing
Languages : en
Pages : 0

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Book Description
This timely work reflects on the role and obligations of the state as a buyer of goods and services, from the dual disciplinary perspectives of public procurement and human rights. Through theoretical and doctrinal analyses, and practice-focused case studies, it interrogates the evolving character of public procurement as an interface for multiple normative regimes and competing policies. Challenging the prevailing paradigm which subordinates human rights to narrowly-defined economic goals, insightful contributions advance a compelling case for greater inter-disciplinarity and policy coherence as crucial to realising international policies such as those embodied in the UN Guiding Principles on Business and Human Rights and 2030 Sustainable Development Goals.

Author: Kunal Roy
Publisher: Springer
ISBN: 3319172816
Category : Science
Languages : en
Pages : 129

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Book Description
This brief goes back to basics and describes the Quantitative structure-activity/property relationships (QSARs/QSPRs) that represent predictive models derived from the application of statistical tools correlating biological activity (including therapeutic and toxic) and properties of chemicals (drugs/toxicants/environmental pollutants) with descriptors representative of molecular structure and/or properties. It explains how the sub-discipline of Cheminformatics is used for many applications such as risk assessment, toxicity prediction, property prediction and regulatory decisions apart from drug discovery and lead optimization. The authors also present, in basic terms, how QSARs and related chemometric tools are extensively involved in medicinal chemistry, environmental chemistry and agricultural chemistry for ranking of potential compounds and prioritizing experiments. At present, there is no standard or introductory publication available that introduces this important topic to students of chemistry and pharmacy. With this in mind, the authors have carefully compiled this brief in order to provide a thorough and painless introduction to the fundamental concepts of QSAR/QSPR modelling. The brief is aimed at novice readers.

Author: Gisbert Schneider
Publisher: John Wiley & Sons
ISBN: 3527677038
Category : Medical
Languages : en
Pages : 540

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Book Description
Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more.

Author: Mohammed Othman Almaimani
Publisher: Trafford Publishing
ISBN: 9781698703558
Category :
Languages : en
Pages : 1006

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Book Description
Essential Notes in General Surgery is a summary of years of work, after reading several text books, articles, attending the conferences, hospital daily rounds, and many review courses. It is précis, digested, updated and provides essential knowledge that will help you pass the board exams, especially the American, Canadian, and Saudi board exams. This book was designed to be sufficiently used by medical students, general surgery residents and senior general surgeon. The book contains basic knowledge of the anatomy, physiology, pathology as well as history, physical examination, investigation, detailed management, operative intervention, and follow-up of each disease. The material is divided into three main sections: - Basic surgical principles Fluids, hemostasis, shock, surgical infection, trauma, wound healing, and critical care - General surgery Upper GIT, Colorectal, Hepatobiliary, and Endocrine surgery - Subspecialty Pediatric, Vascular, bariatric and Thoracic surgery. For enquiries [email protected]