Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Clinical Trials Risk Management PDF full book. Access full book title Clinical Trials Risk Management by Martin Robinson. Download full books in PDF and EPUB format.
Author: Martin Robinson Publisher: CRC Press ISBN: 9780849333231 Category : Medical Languages : en Pages : 232
Book Description
Drug development is risky business. It is against the backdrop of huge financial, scientific, technical and medical risks that a clinical trials manager is expected to function, effectively identifying and managing all project risks, to deliver a successful outcome. Focusing on the day-to-day needs of a clinical trials manager, Clinical Trials Risk Management explains the key concepts and principles of risk management, as well as showing how best to how to apply them directly to 'real life' clinical trial situations. After building a foundation of basic principles, the authors lead you through specific methods for handling the risks characteristically encountered in clinical trials. Their combined years of experience in pharmaceutical research and development shine through the narrative, making the prose both lively and informative. They discuss concepts using worked examples and include a summary of the main points at the end of each chapter. In addition to diagrams and Risk and Precision Tree charts, the text is sprinkled with humorous line drawings that reinforce the concepts. After reading this book, you will know how to: Prepare a Risk Assessment Design an Impact-Probability Matrix Compile a Risk Register Run a Monte Carlo Simulation Set up a Project Decision Tree Plan preventative and contingency actions The stand-alone chapters provide easy access to topics, while anecdotal and visual examples make them easy to remember. Martin Robinson and Simon Cook deliver a clear interpretation of complex information, thus saving you the time it would take to wade through a lengthier text, adopting a straightforward approach to examining clinical trials from a risk manager's perspective. A practical, readable guide, the book is filled with information that can be put to immediate use to improve current or planned clinical trials.
Author: Martin Robinson Publisher: CRC Press ISBN: 9780849333231 Category : Medical Languages : en Pages : 232
Book Description
Drug development is risky business. It is against the backdrop of huge financial, scientific, technical and medical risks that a clinical trials manager is expected to function, effectively identifying and managing all project risks, to deliver a successful outcome. Focusing on the day-to-day needs of a clinical trials manager, Clinical Trials Risk Management explains the key concepts and principles of risk management, as well as showing how best to how to apply them directly to 'real life' clinical trial situations. After building a foundation of basic principles, the authors lead you through specific methods for handling the risks characteristically encountered in clinical trials. Their combined years of experience in pharmaceutical research and development shine through the narrative, making the prose both lively and informative. They discuss concepts using worked examples and include a summary of the main points at the end of each chapter. In addition to diagrams and Risk and Precision Tree charts, the text is sprinkled with humorous line drawings that reinforce the concepts. After reading this book, you will know how to: Prepare a Risk Assessment Design an Impact-Probability Matrix Compile a Risk Register Run a Monte Carlo Simulation Set up a Project Decision Tree Plan preventative and contingency actions The stand-alone chapters provide easy access to topics, while anecdotal and visual examples make them easy to remember. Martin Robinson and Simon Cook deliver a clear interpretation of complex information, thus saving you the time it would take to wade through a lengthier text, adopting a straightforward approach to examining clinical trials from a risk manager's perspective. A practical, readable guide, the book is filled with information that can be put to immediate use to improve current or planned clinical trials.
Author: Pedro Castelo-Branco Publisher: Academic Press ISBN: 0128164220 Category : Science Languages : en Pages : 490
Book Description
Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.
Author: Tom Hockaday Publisher: Johns Hopkins University Press ISBN: 1421437058 Category : Education Languages : en Pages : 351
Book Description
Demystifying technology transfer—an increasingly important but little-understood aspect of research universities' mission. How do we transfer the brilliance of university research results into new products, services, and medicines to benefit society? University research is creating the technologies of tomorrow in the fields of medicine, engineering, information technology, robotics, and artificial intelligence. These early-stage technologies need investment from existing and new businesses to benefit society. But how do we connect university research outputs with business and investors? This process, Tom Hockaday explains, is what university technology transfer is all about: identifying, protecting, and marketing university research outputs in order to shift opportunities from the university into business. In this detailed introductory book—a comprehensive overview of and guide to the subject—Hockaday, an internationally recognized technology transfer expert, offers up his insider observations, opinions, and suggestions about university technology transfer. He also explains how to develop, strategically operate, and fund university technology transfer offices while behaving in accordance with the central mission of the university. Aimed at people who work in or with university technology transfer offices, as well as anyone who wants to learn the basics of what is involved, University Technology Transfer speaks to a global audience. Tackling a complex topic in clear language, the book reveals the impressive scale of patenting, licensing, and spin-out company creation while also demonstrating that university technology transfer is a commercial activity with benefits that go well beyond the opportunity to make money.
Author: A. Victor Hoffbrand Publisher: John Wiley & Sons ISBN: 1405143533 Category : Medical Languages : en Pages : 1091
Book Description
"Most hematologists need a revised and practical textbook in whichthey can rapidly search on the morning of a consultation...Thisbook will be an important resource in suchsituations." New England Journal of Medicine A well established and respected review ofhematology Postgraduate Haematology is a practical, readable text whichwill give trainees, residents and practising hematologistsup-to-date knowledge of the pathogenesis, clinical and laboratoryfeatures and management of blood disorders. Postgraduate Haematology is ideal for: Trainees and residents in hematology Hematologists in practice Why Buy This Book? A well established and respected review ofhematology Practical and readable text Essential information for everyday use as well as thescientific background Up-to-date knowledge of the pathogenesis, clinical andlaboratory features and management of blood disorders Complete revision of all chapters and the addition of newchapters to reflect latest advances in the speciality
Author: International Atomic Energy Agency Publisher: ISBN: 9789201150134 Category : Medical Languages : en Pages : 544
Book Description
Cancer treatment is complex and calls for a diverse set of services. Radiation therapy is recognized as an essential tool in the cure and palliation of cancer. Currently, access to radiation treatment is limited in many countries and non-existent in some. This lack of radiation therapy resources exacerbates the burden of disease and underscores the continuing health care disparity among States. Closing this gap represents an essential measure in addressing this global health equity problem. This publication presents a comprehensive overview of the major topics and issues to be taken into consideration when planning a strategy to address this problem, in particular in low and middle income countries. With contributions from leaders in the field, it provides an introduction to the achievements and issues of radiation therapy as a cancer treatment modality around the world. Dedicated chapters focus on the new radiotherapy technologies, proton beams, carbon ion, intraoperative radiotherapy, radiotherapy for children, treatment of HIV-AIDS malignancies, and costing and quality management issues.
Author: Waldo Heinrichs Publisher: Oxford University Press ISBN: 0190616768 Category : History Languages : en Pages : 744
Book Description
On May 8, 1945, Victory in Europe Day-shortened to "V.E. Day"-brought with it the demise of Nazi Germany. But for the Allies, the war was only half-won. Exhausted but exuberant American soldiers, ready to return home, were sent to join the fighting in the Pacific, which by the spring and summer of 1945 had turned into a gruelling campaign of bloody attrition against an enemy determined to fight to the last man. Germany had surrendered unconditionally. The Japanese would clearly make the conditions of victory extraordinarily high. In the United States, Americans clamored for their troops to come home and for a return to a peacetime economy. Politics intruded upon military policy while a new and untested president struggled to strategize among a military command that was often mired in rivalry. The task of defeating the Japanese seemed nearly unsurmountable, even while plans to invade the home islands were being drawn. Army Chief of Staff General George C. Marshall warned of the toll that "the agony of enduring battle" would likely take. General Douglas MacArthur clashed with Marshall and Admiral Nimitz over the most effective way to defeat the increasingly resilient Japanese combatants. In the midst of this division, the Army began a program of partial demobilization of troops in Europe, which depleted units at a time when they most needed experienced soldiers. In this context of military emergency, the fearsome projections of the human cost of invading the Japanese homeland, and weakening social and political will, victory was salvaged by means of a horrific new weapon. As one Army staff officer admitted, "The capitulation of Hirohito saved our necks." In Implacable Foes, award-winning historians Waldo Heinrichs (a veteran of both theatres of war in World War II) and Marc Gallicchio bring to life the final year of World War Two in the Pacific right up to the dropping of the atomic bombs over Hiroshima and Nagasaki, evoking not only Japanese policies of desperate defense, but the sometimes rancorous debates on the home front. They deliver a gripping and provocative narrative that challenges the decision-making of U.S. leaders and delineates the consequences of prioritizing the European front. The result is a masterly work of military history that evaluates the nearly insurmountable trials associated with waging global war and the sacrifices necessary to succeed.
Author: Steven Gray Publisher: Academic Press ISBN: 0128002247 Category : Medical Languages : en Pages : 748
Book Description
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas - Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs
Author: Chunfu Wu Publisher: Academic Press ISBN: 012823685X Category : Science Languages : en Pages : 146
Book Description
Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers. - Presents detailed diagrams of the mechanisms of epigenetic regulation for easy consult - Encompasses multiple clinical trial summary diagrams to help readers quickly and clearly get information from clinical trials - Provides future perspectives in each section to inspire readers to use epigenetic regulation to overcome chemo-resistance
Author: Franco Cavalli Publisher: CRC Press ISBN: 1000611299 Category : Medical Languages : en Pages : 427
Book Description
Lymphomas classically manifest themselves in the lymph nodes but can also present in other bodily tissues or systems; the organ where exactly they present may make a very great difference to the strategy that should be adopted for their management. This topic has only recently been consistently addressed as an issue on its own, apart from the rest
Author: Howard J. Weinstein Publisher: Springer Science & Business Media ISBN: 354068753X Category : Medical Languages : en Pages : 296
Book Description
This is a comprehensive textbook of Hodgkin's and non-Hodgkin's lymphomas written by leaders in the field of childhood lymphomas. It includes clinical, pathologic and molecular biology of each subtype of lymphoma. The pathology chapters are comprehensive and include excellent photographs. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology.
Author: Martin Robinson
Author: Martin Robinson
Author: Pedro Castelo-Branco
Author: Tom Hockaday
Author: A. Victor Hoffbrand
Author: International Atomic Energy Agency
Author: Waldo Heinrichs
Author: Steven Gray
Author: Chunfu Wu
Author: Franco Cavalli
Author: Howard J. Weinstein