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Author: Stefan R. Schmidt Publisher: John Wiley & Sons ISBN: 1118354583 Category : Medical Languages : en Pages : 995
Book Description
The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.
Author: Stefan R. Schmidt Publisher: John Wiley & Sons ISBN: 1118354583 Category : Medical Languages : en Pages : 995
Book Description
The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.
Author: Alison E Ashcroft Publisher: Royal Society of Chemistry ISBN: 1839162899 Category : Science Languages : en Pages : 621
Book Description
Over the last decade, the use of ion mobility separation in combination with mass spectrometry analysis has developed significantly. This technique adds a unique extra dimension enabling the in-depth analysis of a wide range of complex samples in the areas of the chemical and biological sciences. Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and with numerous different commercial platforms to choose from, this book will help the end users understand the practicalities of using different instruments for different ion mobility purposes. The first section provides a detailed account of the fundamentals behind the technique and the current range of available instrumentation. The second section focusses on the wide range of applications that have benefitted from ion mobility – mass spectrometry and includes topics taken from current research in the pharmaceutical, metabolomics, glycomics, and structural molecular biology fields. The book is primarily aimed at researchers, appealing to practising chemists and biochemists, as well as those in the pharmaceutical and medical fields.
Author: Alan B. G. Lansdown Publisher: Royal Society of Chemistry ISBN: 1849731799 Category : Technology & Engineering Languages : en Pages : 275
Book Description
Silver in healthcare has many different facets and since the early concepts of microbiology of the 1880's, has been developed from usage in surgical clips, staples, foil wound dressings and surgical implants, to the widespread and clinically effective antiseptic wound dressings, sutures, catheters, bone and dental implants, and cardiovascular devices of today. From the dawn of human civilisation, silver has had a role of water purification and even now has a role in hospital water systems for control of MRSA and legionnaires disease. Biotechnological advances in recent years have extended the antimicrobial properties of silver into production of hygiene textiles and use in domestic products. Important advances have been made in understanding mechanisms of antimicrobial action of silver, the central importance of ionisation patterns in the presence of body fluids and secretion, and the genetical and molecular profiles of silver resistance. This publication is a comprehensive account of the history of silver in medicine, its clinical benefits and wide advantages as a broad spectrum antimicrobial agent. It is clear from the extensive array of publications in recognised and unofficial press, that many misconceptions and misleading conceptions have been perpetuated, leading to errors in evaluation of the safety of the metal in occupational, domestic and therapeutic situations. The book is unique in that it is the only comprehensive presentation of the toxicology of silver and it identifies the major misconceptions in the safety of silver and interpretation of argyria and argyrosis as central features of silver toxicity. In this book, Dr Lansdown reviews the literature from a clinical and experimental viewpoint, with the benefit of his many years research on silver and experience gained in working with clinicians, healthcare product manufacturers and microbiologists. There is also discussion in the book on the relevance of antimicrobial resistance to silver and deficiencies in present day clinical practice in not evaluating incidences of resistance on a routine basis. The subject matter is presented in a readable fashion and includes reference to use of the metal in such practices as acupuncture and treatment of tropical diseases as practised in some parts of the world, each of which is accompanied by special clinical risk. It is also a collation of current views on the use and efficacy of silver as a broad spectrum antibiotic. The chapters which deal specifically with toxicological aspects of silver in clinical, occupational and environmental issues are central to the book's value. The book is aimed at clinicians, research scientists and product manufacturers and will provide ideas for new research and academic endeavour. It is also essential reading for research students with an interest in metal toxicity and its management in mammalian tissues.
Author: Publisher: ISBN: Category : Data centers Languages : en Pages : 1784
Book Description
Comprehensive directory of databases as well as services "involved in the production and distribution of information in electronic form." There is a detailed subject index and function/service classification as well as name, keyword, and geographical location indexes.
Author: Adrian Horridge Publisher: CABI ISBN: 1789240891 Category : Science Languages : en Pages : 293
Book Description
This book is the only account of what honeybees actually see. Bees detect some visual features such as edges and colours, but there is no sign that they reconstruct patterns or put together features to form objects. Bees detect motion but have no perception of what it is that moves, and certainly they do not recognize "things" by their shapes. Yet they clearly see well enough to fly and find food with a minute brain. Bee vision is therefore relevant to the construction of simple artificial visual systems, for example for mobile robots. The surprising conclusion is that bee vision is adapted to the recognition of places, not things. In this volume, Adrian Horridge also sets out the curious and contentious history of how bee vision came to be understood, with an account of a century of neglect of old experimental results, errors of interpretation, sharp disagreements, and failures of the scientific method. The design of the experiments and the methods of making inferences from observations are also critically examined, with the conclusion that scientists are often hesitant, imperfect and misleading, ignore the work of others, and fail to consider alternative explanations. The erratic path to understanding makes interesting reading for anyone with an interest in the workings of science but particularly those researching insect vision and invertebrate sensory systems.
Author: Marek Domin Publisher: Royal Society of Chemistry ISBN: 1849739269 Category : Science Languages : en Pages : 528
Book Description
Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.
Author: Angeles Canales Publisher: Royal Society of Chemistry ISBN: 1788012860 Category : Science Languages : en Pages : 336
Book Description
Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.
Author: Tiffany Siegel Porta Publisher: Royal Society of Chemistry ISBN: 1839162414 Category : Science Languages : en Pages : 541
Book Description
This book gathers knowledge about matrix-assisted laser desorption ionisation (MALDI) mass spectrometry imaging for postgraduate and professional researchers in academia and in industry where it has direct application to clinical research.
Author: Stefan R. Schmidt
Author: Stefan R. Schmidt
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Author: 
Author: Alison E Ashcroft
Author: Alan B. G. Lansdown
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Author: Adrian Horridge
Author: Marek Domin
Author: Angeles Canales
Author: Tiffany Siegel Porta