Cloning and Characterization of the Receptor for TPF (Tumor Promoting Factor), A Novel Angiogenic Factor PDF Download
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Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
The regulation of the Transforming Growth Factor-Beta (TGF-Beta) signaling pathway and its role in cancer is an area of intense research. We are investigating the regulatory role of casein kinase I (CKI) in the TGF-Beta signaling cascade. We have found that one family member inparticular, CKI epsilon, binds to all Smads and the cytoplasmic domains of the Type I and Type II receptors both in vitro and in vivo. The interaction of CKI epsilon with the Type I and Type II receptors is independent of TGF-beta ligand stimulation. However, the CKI epsilon/Smad interaction is transiently disrupted by TGF-beta stimulation, with complete disassociation by 2 hours. Since CKI epsilon is also a serine/threonine kinase, we examined in vitro phosphorylation of Smads and receptors by CKI epsilon and found that only the receptor activated Smads and the Type II Receptor are phosphorylated by CKI epsilon. In addition, we have mapped the CKIs phosphorylation sites of Smad3 to the MH1 domain and the linker region. Furthermore, in the absence of TGF-beta, transient overexpression of CKI epsilon dramatically reduces basal transcriptional reporter activity, but in the presence of ligand CKI epsilon increases TGF-beta mediated transcription. Finally, CKI epsilon is capable of significantly enhancing the transcriptional activity of smad3. Taken together, these observations provide exciting evidence for a functional role of CKI epsilon in the TGF-beta pathway, a pathway that has been shown to be involved in the development and progression of many different types of cancers.
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
The regulation of the Transforming Growth Factor-Beta (TGF-Beta) signaling pathway and its role in cancer is an area of intense research. We are investigating the regulatory role of casein kinase I (CKI) in the TGF-Beta signaling cascade. We have found that one family member inparticular, CKI epsilon, binds to all Smads and the cytoplasmic domains of the Type I and Type II receptors both in vitro and in vivo. The interaction of CKI epsilon with the Type I and Type II receptors is independent of TGF-beta ligand stimulation. However, the CKI epsilon/Smad interaction is transiently disrupted by TGF-beta stimulation, with complete disassociation by 2 hours. Since CKI epsilon is also a serine/threonine kinase, we examined in vitro phosphorylation of Smads and receptors by CKI epsilon and found that only the receptor activated Smads and the Type II Receptor are phosphorylated by CKI epsilon. In addition, we have mapped the CKIs phosphorylation sites of Smad3 to the MH1 domain and the linker region. Furthermore, in the absence of TGF-beta, transient overexpression of CKI epsilon dramatically reduces basal transcriptional reporter activity, but in the presence of ligand CKI epsilon increases TGF-beta mediated transcription. Finally, CKI epsilon is capable of significantly enhancing the transcriptional activity of smad3. Taken together, these observations provide exciting evidence for a functional role of CKI epsilon in the TGF-beta pathway, a pathway that has been shown to be involved in the development and progression of many different types of cancers.
Author: J. Whicher Publisher: Springer Science & Business Media ISBN: 9401129967 Category : Medical Languages : en Pages : 316
Book Description
Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated. The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself. This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions.
Author: Surinder K. Batra Publisher: CRC Press ISBN: 1351778323 Category : Medical Languages : en Pages : 315
Book Description
Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.
Author: Ranjith Senaratne Publisher: Springer Nature ISBN: 3030544265 Category : Science Languages : en Pages : 453
Book Description
Cinnamon is the common name for the spice obtained from the dried inner bark of several species of the genus Cinnamomum in the Lauraceae family. In world trade, Cinnamomum cassia (L.) J. Presl Cinnamomum burmannii dominate, but it is of a different quality to ‘true’ or ‘Ceylon’ cinnamon produced from Cinnamomum zeylanicum Blume (C. verum J. Presl), with the latter much easier to process, giving a more delicate, sweeter flavor with nuances of clove, but more importantly with only traces (often below detection thresholds) of coumarin, compared with 5–7 g/kg in other species. Cinnamon has been a popular and expensive spice in many civilizations, including ancient Egypt, Rome and in 14th and 15th century Europe, where it was used primarily to preserve meat for its antibacterial properties, fine aroma and flavor. Ancient Egyptians used cinnamon in mummification process due to its antibacterial properties and fragrance. The quest for cinnamon brought many explorers to Ceylon, whose ancient history is intertwined with the cinnamon trade. Ancient Egyptians and Romans used cinnamon as a valued spice and as an incense. In recent years, much research has been conducted in crop improvement, processing and value addition in cinnamon. In addition to direct use as a condiment/spice, cinnamon has found a multitude of uses in the food and beverage, traditional medicine, pharmacology, nutraceutical and cosmetics industries. Ceylon cinnamon is unique in that oils distilled from the bark (major constituents are cinnamaldehyde and oleoresins), leaf (eugenol is the major constituent used in dentistry, perfumes, flavorings and as an antioxidant) and roots (camphor) have different industrial uses. Cinnamaldehyde is now a proven natural bactericide widely used in food and beverage industry, effective against Salmonella spp. and Escherichia coli. Thus, it has become an important natural component of organic fruit and vegetable juices to enhance microbial safety of these nutritious beverages. Because of its manifold uses, cinnamon is an important crop. There have been many recent publications on its ethnobotany, genetics, crop improvement, agronomy, processing, biotechnology, chemistry, food and medicinal uses, and industrial applications. However, one book condensing all these findings is lacking. Our publication, with chapters devoted to all these aspects of cinnamon written by experts in these fields, condenses current knowledge into a single source and contribute to the advancement and dissemination of knowledge and technology. Contributors to the book constitute internationally renowned senior scientists and academics with hands-on experience as well as movers and shakers of industry, thereby striking a right balance between theory and practice. Therefore it is a valuable source for students, teachers, scientists, planners policy makers, practicing agriculturists and industrialists, and a prized acquisition to any library in higher education institutions, R & D institutions and public and private sector institutions in agriculture and allied fields.
Author: Steven E. Schild, MD Publisher: Demos Medical Publishing ISBN: 1935281801 Category : Medical Languages : en Pages : 260
Book Description
Thoracic Malignancies: Thoracic Malignancies is the first title in Radiation Medicine Rounds. These tumors take more lives than any others and they are among the most preventable of tumors. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Thoracic Malignancies addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and thymomas providing coverage of the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up-to-date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future. About the Series Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of Ïhot topicsÓ and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice
Author: Jianren Gu Publisher: Springer Science & Business Media ISBN: 3642287026 Category : Medical Languages : en Pages : 479
Book Description
"Primary Liver Cancer: Challenges and Perspectives" presents the recent progress in basic and clinical research in Primary Liver Cancer (PLC) in China and around the world. PLC patients in China make up more than 50% of the total patients worldwide. By contributing to the book, the leading experts in the field of liver cancer in China as well as in the US share with readers their new concepts, practices, and experiences from bench to bed, from population study to individual survey, from molecular search to clinical practice, and from early diagnosis to treatment. The book is intended for researchers in the fields of epidemiology, molecular genetics, cell biology, immunology of HCC and other cancers, and clinical oncology in primary liver cancer. Jianren Gu is a Professor of molecular oncology at the Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine and Academician of Chinese Academy of Engineering.
Author: L Karthik Publisher: CRC Press ISBN: 0429555784 Category : Medical Languages : en Pages : 299
Book Description
Biological Synthesis of Nanoparticles and Their Applications gives insight into the synthesis of nanoparticles utilizing the natural routes. It demonstrates various strategies for the synthesis of nanoparticles utilizing plants, microscopic organisms like bacteria, fungi, algae and so forth. It orchestrates interdisciplinary hypothesis, ideas, definitions, models and discoveries associated with complex cell of the prokaryotes and eukaryotes. Highlights: Discusses biological approach towards the nanoparticle synthesis Describes the role of nanotechnology in the field of medicine and its medical devices Covers application and usage of the chemicals at the molecular level to act as catalysts and binding products for both organic and inorganic Chemical Reactions Reviews application in physics such as solar cells, photovoltaics and other usage Microorganisms can aggregate and detoxify substantial metals because of different reductase enzymes, which can diminish metal salts to metal nanoparticles. The readers after going through this book will have detailed account of mechanism of bio-synthesis of nanoparticles.
Author: Takehiro Izumo Publisher: Springer ISBN: 9812879161 Category : Medical Languages : en Pages : 251
Book Description
This book provides a detailed overview of the latest innovations in respiratory endoscopy, from both diagnostic and therapeutic perspectives; each chapter focuses on one disease and the techniques for early diagnosis as well as treatment. It comprehensively covers treatment and procedures, including simultaneous X-ray fluoroscopy and its use during bronchoscopic procedures. This fast-developing technology is essential for the medical management of non-malignant and malignant diseases of the chest, especially lung cancer. Respiratory Endoscopy describes the cooperation between all the members of the healthcare team, and as such is a valuable resource not only for medical staff, but also for radiological technicians and nursing staff who contribute significantly in the care of the patients undergoing these invasive procedures. By promoting teamwork and providing practical know-how, it will improve the success and safety of respiratory endoscopy procedures.
Author: Daan J. A. Crommelin Publisher: CRC Press ISBN: 9780415285018 Category : Medical Languages : en Pages : 456
Book Description
The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
Author: Bernardo L. Rapoport Publisher: Karger Medical and Scientific Publishers ISBN: 3318068187 Category : Medical Languages : en Pages : 109
Book Description
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
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Author: 
Author: J. Whicher
Author: Surinder K. Batra
Author: Ranjith Senaratne
Author: Steven E. Schild, MD
Author: Jianren Gu
Author: L Karthik
Author: Takehiro Izumo
Author: Daan J. A. Crommelin
Author: Bernardo L. Rapoport