Characterisation of Turbulent Mixing and Its Influence on Antisolvent Crystallisation PDF Download

Author: Andrew Brown
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Robert Brodkey
Publisher: Elsevier
ISBN: 0323154689
Category : Technology & Engineering
Languages : en
Pages : 352

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Book Description
Turbulence in Mixing Operations: Theory and Application to Mixing and Reaction presents a summary of the current status of research on turbulent motion, mixing, and kinetics. Each chapter of this book discusses turbulence in the context of mixing and reaction in scalar fields. Chapters I and III discuss the classification of turbulent reacting systems and the different possibilities in this context. Chapter II reviews the properties of passive mixing. Chapter IV looks at turbulent mixing in chemically reactive flows. Chapter V uses different techniques to make parallel numerical calculations of both mixing and reaction. Finally, Chapter VI reviews turbulence and actual industrial mixing operations. This book will be of great value for chemical and industrial engineers, especially for those interested in turbulent and industrial mixing.

Author: Ronald E. Rosensweig
Publisher:
ISBN:
Category : Chemical engineering
Languages : en
Pages : 199

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Author:
Publisher: IChemE
ISBN: 0852954247
Category : Chemical engineering
Languages : en
Pages : 2454

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This conference provides a forum for discussion of the advances in the theory and practice of crystallization as it relates to the production of bulk crystalline materials.

Author: Xing Yi Woo
Publisher: ProQuest
ISBN: 9780549342502
Category :
Languages : en
Pages : 238

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Book Description
This dissertation presents the development of simulation tools to address the issues of mixing and control in antisolvent crystallization processes, and to aid the development of systematic and scientific design approaches. The first part presents the development of an algorithm that couples macromixing and micromixing models with the population balance equation. It was applied to simulate antisolvent crystallization in a semibatch stirred vessel and an impinging jet crystallizer. The effects of the operational variables on the crystal size distribution and polymorphic form were numerically investigated. The second part focuses on the theoretical development and analysis of control strategies applied to antisolvent crystallization processes. For semibatch crystallization, the advantage of concentration control over specification of antisolvent addition rate was demonstrated by sensitivity analysis to process disturbances. For impinging jet crystallizers, it is shown that, by coupling with an aging vessel with controlled growth, specific crystal size distributions can be tailored.

Author: David J. am Ende
Publisher: John Wiley & Sons
ISBN: 1119285860
Category : Technology & Engineering
Languages : en
Pages : 1172

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Book Description
A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying Presents updated and expanded example calculations Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industryf ocuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.

Author: H. W. Liepmann
Publisher:
ISBN:
Category :
Languages : en
Pages : 290

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The combustion facility (H2-F2) is now nearing completion. As of this writing, a high speed mixing layer has been realized in the test section, using high pressure air. This certifies the flow facility down to and including the test section. Preliminary results on the effect of high heat release in a turbulent mixing zone were obtained in the NO-O3 experiment. These results are consistent with predictions based on previously measured p.d.f, 's in non-reacting mixing layers, but in conspicuous disagreements with a variety of accepted model calculations. These results demonstrate again the important influence of the large scale coherent structures on chemical reactions in turbulent flows. The Laser Induced Fluorescence technique has now been extended to allow direct space and time resolved measurements of the reaction products. The first four channels of the multi-channel laser Doppler velocimetry system are essentially completed. The first experiments using this new development are expected in the course of this summer. Digital image analysis of particle streak photography has also been explored as a direct means of two-dimensional measurements of the velocity field in a plane. Finally, a prototype system using a 100 element acoustic detector array has been completed. Initial measurements with four of these channels using 300 kHz sound have been successfully made. (Author).

Author: A. Mersmann
Publisher: CRC Press
ISBN: 0824745116
Category : Science
Languages : en
Pages : 847

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This handbook seeks to facilitate the selection, design and operation of large-scale industrial crystallizers that process crystals with the proper size distribution, shape and purity sought. This second edition offers results on direct-contact cooling crystallization.

Author:
Publisher:
ISBN:
Category : Chemical engineering
Languages : en
Pages : 676

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Author: Alison Lewis
Publisher: Cambridge University Press
ISBN: 1316299082
Category : Technology & Engineering
Languages : en
Pages : 354

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Book Description
Bridging the gap between theory and practice, this text provides the reader with a comprehensive overview of industrial crystallization. Newcomers will learn all of the most important topics in industrial crystallization, from key concepts and basic theory to industrial practices. Topics covered include the characterization of a crystalline product and the basic process design for crystallization, as well as batch crystallization, measurement techniques, and details on precipitation, melt crystallization and polymorphism. Each chapter begins with an introduction explaining the importance of the topic, and is supported by homework problems and worked examples. Real world case studies are also provided, as well as new industry-relevant information, making this is an ideal resource for industry practitioners, students, and researchers in the fields of industrial crystallization, separation processes, particle synthesis, and particle technology.