Central Nervous System: From Aging to Repair and Regeneration PDF Download

Author: Homaira Nawabi
Publisher: Frontiers Media SA
ISBN: 2889768937
Category : Science
Languages : en
Pages : 147

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Author: Fredrick J. Seil
Publisher: Lippincott Williams & Wilkins
ISBN:
Category : Alzheimer's disease
Languages : en
Pages : 392

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Book Description
Describes the mechanisms by which the nervous system is injured in disease and in trauma, examines repair or regenerative responses to neural injury, and explores therapeutic interventions aimed at promoting these responses.

Author: Shuxin Li
Publisher: Frontiers Media SA
ISBN: 288974633X
Category : Science
Languages : en
Pages : 399

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Author: Wolfgang J. Streit
Publisher: Springer Science & Business Media
ISBN: 1475741391
Category : Science
Languages : en
Pages : 326

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Book Description
The study of microglial cells has recently gained importance for those researching degeneration and regeneration. Microglia in the regenerating and degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and reviews their cell function and physiology.

Author: Paola S. Timiras
Publisher: Springer Science & Business Media
ISBN: 1468480472
Category : Science
Languages : en
Pages : 362

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Book Description
Proceedings of the Third Conference of the Institute of Developmental Neuroscience and Aging, held in Torino, Italy, April 5-7, 1990

Author: Charles E. Ribak PhD
Publisher: Oxford University Press
ISBN: 0195369009
Category : Medical
Languages : en
Pages : 404

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Book Description
This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

Author: Jeffrey Kordower
Publisher: Elsevier
ISBN: 9780080556987
Category : Science
Languages : en
Pages : 526

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Book Description
This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS

Author: Stephen W. Scheff
Publisher: Springer Science & Business Media
ISBN: 1461327059
Category : Medical
Languages : en
Pages : 228

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Book Description
The mammalian central nervous system is a remarkable structure which has attracted many new investigators, as evidenced by the dramatic increase in scientific publications dealing with neurobiology. Every day basic scientists conduct new and exciting experiments, resulting in remarkable discoveries des tined to help mankind. Unfortunately many of these new findings are slow to be accepted by the clinical world. This is especially true in the area of brain trauma, where the present prognosis is usually very poor. We have known for quite some time that the mammalian central nervous system is capable of compensating for severe damage in many different ways, and under some circumstances behav ioral compensation can be observed. However, much is still to be learned about the various factors and events that lead to functional recovery and those condi tions that do not. It is this challenge that originally excited a number of the contributors to this volume to explore the subject of recovery from brain damage. One factor in particular that is known to change the prognosis of recovery is the age of the organism at the time of the damage. This book is an attempt to explore this important variable. Most of the literature concerning aging deals with widespread degenerative changes and paints a grim picture for the aging central nervous system in terms of recovery of function following trauma.

Author: Michael E. Selzer
Publisher: Cambridge University Press
ISBN: 1107011671
Category : Nervous system
Languages : en
Pages : 693

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Book Description
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

Author: Ezio Giacobini
Publisher: Raven Press (ID)
ISBN:
Category : Aging
Languages : en
Pages : 312

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