Stem Cell Manufacturing PDF Download

Author: Joaquim M.S. Cabral
Publisher: Elsevier
ISBN: 0444632662
Category : Medical
Languages : en
Pages : 342

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Book Description
Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders. Presents the first ‘Flowchart‘ of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book

Author: Yuji Morimoto
Publisher: Springer
ISBN: 9789819742554
Category : Science
Languages : en
Pages : 0

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Book Description
Animal cells have been used in a wide range of applications, from pharmaceuticals to regenerative medicine and cell therapy, as well as evaluating drugs and compounds. These applications are supported by cell processing technology, which refers to the process technology and quality control technology for aseptically culturing cells such as skin, cartilage, and bone cells in vitro and producing the result of cells or tissues. Cell Processing Technology provides the state of the art of cell-processing engineering, including new issues of efficient and automated culture technology of cells in transplantation and non-invasive cell quality assessment technology. The book will be of value to students and inexperienced engineers who are involved in drug discovery and cell medicine.

Author: Klaus Schindhelm
Publisher: Academic Press
ISBN:
Category : Health & Fitness
Languages : en
Pages : 392

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Book Description
R.E. Nordon and K. Schindhelm, Introduction. -- L. Robb, A.G. Elefanty, and C.G. Begley, Transcriptional Control of Hematopoieses. -- R. Starr and N.A. Nicola, Cell Signaling by Hemopoietic Growth Factor Receptors. -- P.J. Simmons, D.N. Haylock, and J.-P. Lévesque, Influence of Cytokines and Adhesion Molecules on Hematopoietic Stem Cell Development. -- P.A. Rowlings, Allogeneic Hematopoietic Stem Cell Transplantation. -- U. Hahn and L.B. To, Autologous Stem Cell Transplantation. -- M.R. Vowels, Cord Blood Stem Cell Transplantation. -- S.R. Riddell, E.H. Warren, D. Lewinsohn, C. Yee, and P.D. Greenberg, Reconstitution of Immunity by Adoptive Immunotherapy with T Cells. -- L.Q. Sun, M. Miller, and G. Symonds, Exogenous Gene Transfer into Lymphoid and Hematopoietic Progenitor Cells. -- C. Dowding, T. Leemhuis, A. Jakubowski, and C. Reading, Process Development for Ex Vivo Cell Therapy. -- R.E. Nordon and K. Schindhelm, Cell Separation. -- P.W. Zandstra, C.J. Eaves, and J.M. Piret, Environ ...

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309170427
Category : Science
Languages : en
Pages : 112

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Book Description
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Author: Deirdre Fehily
Publisher: John Wiley & Sons
ISBN: 1118316509
Category : Medical
Languages : en
Pages : 296

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Book Description
By presenting the latest technological advances and growing national and international regulation, this new book explores state-of-the-art developments in the challenging field of tissue and cell processing. It provides a guide to easier and safer practice in operational principles of preservation, decontamination, and sterilization. Nearly half of the book is devoted completely to tissue- or cell-specific issues relating to processing. With lists of learning points and case studies which consist of sample processing protocols, descriptions of where processing went wrong, sample risk assessments, or validation studies, the authors help you find specific information fast.

Author: Adrian Gee
Publisher: Springer Science & Business Media
ISBN: 0387895841
Category : Science
Languages : en
Pages : 258

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Book Description
Cell Therapy: cGMP Facilities and Manufacturing is the source for a complete discussion of facility design and operation with practical approaches to a variety of day-to-day activities, such as staff training and competency, cleaning procedures, and environmental monitoring. This in-depth book also includes detailed reviews of quality, the framework of regulations, and professional standards. It meets a previously unmet need for a thorough facility-focused resource, Cell Therapy: cGMP Facilities and Manufacturing will be an important addition to the cell therapy professional’s library. Additional topics in Cell Therapy: cGMP Facilities and Manufacturing...Standard operating procedures - Supply management - Facility equipment - Product manufacturing, review, release and administration - Facility master file.

Author: Brett A. Hoover
Publisher:
ISBN:
Category :
Languages : en
Pages : 48

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Book Description
This thesis is a proposal for developing and commercializing a cellular characterization and processing technology (Smart CellectorTM) for application in cell-based regenerative medicine, and includes an overview of stem cells, their therapeutic applications, the technology platform, and the commercialization strategy. Smart Cellector is a modular platform that will automate and standardize stem cell processing for use in cellular therapies to address the need to reduce the cost, time, labor and variability associated with manufacturing cells for clinical and research use. [REDACTED] This project is currently a top priority within the [REDACTED] pipeline with work scheduled to begin in January 2011. Both companies have solid intellectual property (IP) and expect to generate new IP as development progresses. The go-to-market plan involves partnering with local cell therapy stakeholders, manufacturers, and [REDACTED]. Initial target markets include research centers and autologous cell therapy manufacturers, followed by allogeneic cell therapy manufacturers and large hospitals.

Author: Adrian P. Gee
Publisher: Springer Nature
ISBN: 3030755371
Category : Science
Languages : en
Pages : 681

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Book Description
This new edition presents a fully-updated and expanded look at current Good Manufacturing Practice (cGMP) for cell therapy products. It provides a complete discussion of facility design and operation including details specific to cord blood banking, cell processing, vector production and qualification of a new facility. Several chapters cover facility infrastructure including cleaning and maintenance, vendor qualification, writing a Standard Operating Procedure, staff training, and process validation. The detailed and invaluable product information covers topics like labelling, release and administration, transportation and shipment, et al. Further chapters cover relevant topics like writing and maintaining investigational new drug applications, support opportunities in North America and the European Union, commercial cell processing and quality testing services, and financial considerations for academic GMP facilities. A chapter on future directions rounds out Cell Therapy: cGMP Facilities and Manufacturing making it essential reading for any cell therapy professional involved in the development, use, or management of this type of facility.

Author: Raymond Spier
Publisher: Wiley-Interscience
ISBN:
Category : Science
Languages : en
Pages : 682

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Book Description
Brings together up-to-date information on all key aspects of plant and animal cell technology in a single resource. * Covers scientific, historical, and ethical aspects of biotechnology. * Synthesizes a wealth of information in a valuable one-stop resource. * Invaluable to researchers working animal or plant cell technology.

Author: Nallan C. Suresh
Publisher: Springer Science & Business Media
ISBN: 1461554675
Category : Business & Economics
Languages : en
Pages : 560

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Book Description
Group Technology and Cellular Manufacturing (GT/CM) have been widely-researched areas in the past 15 years and much progress has been made in all branches of GT/CM. Resulting from this research activity has been a proliferation of techniques for part-machine grouping, engineering data bases, expert system-based design methods for identifying part families, new analytical and simulation tools for evaluating performance of cells, new types of cell incorporating robotics and flexible automation, team-based approaches for organizing the work force and much more; however, the field lacks a careful compilation of this research and its outcomes. The editors of this book have commissioned leading researchers and implementers to prepare specific treatments of topics for their special areas of expertise in this broad-based philosophy of manufacturing. The editors have sought to be global both in coverage of topic matters and contributors. Group Technology and Cellular Manufacturing addresses the needs and interests of three groups of individuals in the manufacturing field: academic researchers, industry practitioners, and students. (1) The book provides an up-to-date perspective, incorporating the advances made in GT/CM during the past 15 years. As a natural extension to this research, it synthesizes the latest industry practices and outcomes to guide research to greater real-world relevance. (2) The book makes clear the foundations of GT/CM from the core elements of new developments which are aimed at reducing developmental and manufacturing lead times, costs, and at improving business quality and performance. (3) Finally, the book can be used as a textbook for graduate students in engineering and management for studying the field of Group Technology and Cellular Manufacturing.