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Author: D. Marme Publisher: Springer Science & Business Media ISBN: 3642700705 Category : Science Languages : en Pages : 398
Book Description
The purpose of the present volume is to give a comprehensive and up-to-date 2 survey of the nature and role of calcium ions (Ca +) in the regulation of cel 2 lular function. Since Ca + has gained in interest over the past years as a cel lular messenger in signal transduction, and since the discovery of its cellular receptor protein, calmodulin, has helped in understanding its mode of action in molecular terms, we felt that an interdisciplinary selection of topics from the calcium field could provide a good source of information for all those in terested in calcium-mediated physiology. The volume begins with an overview on the synarchic nature of the two 2 cellular messengers, cyclic AMP and Ca +. The next three chapters deal with 2 the various transport mechanisms for Ca +. The biochemistry and molecular biology of calmodulin, as well as the cellular localization of calmodulin and calmodulin-binding proteins, are reviewed. Calcium regulation of smooth muscle contraction introduces the pharmacology of calcium antagonists.
Author: D. Marme Publisher: Springer Science & Business Media ISBN: 3642700705 Category : Science Languages : en Pages : 398
Book Description
The purpose of the present volume is to give a comprehensive and up-to-date 2 survey of the nature and role of calcium ions (Ca +) in the regulation of cel 2 lular function. Since Ca + has gained in interest over the past years as a cel lular messenger in signal transduction, and since the discovery of its cellular receptor protein, calmodulin, has helped in understanding its mode of action in molecular terms, we felt that an interdisciplinary selection of topics from the calcium field could provide a good source of information for all those in terested in calcium-mediated physiology. The volume begins with an overview on the synarchic nature of the two 2 cellular messengers, cyclic AMP and Ca +. The next three chapters deal with 2 the various transport mechanisms for Ca +. The biochemistry and molecular biology of calmodulin, as well as the cellular localization of calmodulin and calmodulin-binding proteins, are reviewed. Calcium regulation of smooth muscle contraction introduces the pharmacology of calcium antagonists.
Author: Gary Fiskum Publisher: Springer Science & Business Media ISBN: 1468455982 Category : Medical Languages : en Pages : 613
Book Description
A widespread appreciation for the role that calcium plays in cell physiology and patho physiology has now been achieved due to the pioneering studies of many of the scientists who attended the VIIth International Spring Symposium on Health Sciences at George Washington University in Washington, D. C. The participants in this unique meeting rep resented diverse fields of basic and clinical research, such as molecular physiology, oncology, molecular genetics, cardiology, bioenergetics, pathology, and endocrinology. The content of the proceedings of the symposium represents work in these and other areas of biomedical research. Organization of the book is aimed at striking a balance between the biochemistry 2 and physiology of normal cell Ca + metabolism and the pathological consequences of al 2 terations in cell Ca + homeostasis. The first section of the book is devoted to the transport mechanisms responsible for 2 2 regulating intracellular Ca + and the pharmacological modalities for controlling cell Ca + . Particular attention is given to the molecular basis for plasma membrane transport activities, 2 2 including the ATP-driven Ca + pump, the Na + -Ca + exchange system, and voltage sensitive 2 Ca + channels. The second section covers the exciting relationships between phosphoinositide metab 2 olism, signal transduction, and cell Ca + metabolism. This section begins with an eloquent overview by Professor Michael Berridge, who was the keynote speaker at the symposium and the recipient of the scientific merit award.
Author: Michel Félétou Publisher: Morgan & Claypool Publishers ISBN: 1615041230 Category : Science Languages : en Pages : 309
Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: James Sneyd Publisher: Springer Science & Business Media ISBN: 9783540254393 Category : Mathematics Languages : en Pages : 228
Book Description
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
Author: Md. Shahidul Islam Publisher: Springer Science & Business Media ISBN: 9400728875 Category : Medical Languages : en Pages : 1254
Book Description
Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses cutting edge researches, and critical issues at depth, and it presents many testable hypotheses for future research. It includes the theoretical and the methodological topics as well as topics related to mathematical modeling, and simulations. If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. From the beginners to the experts in the field of calcium signaling, everybody will find something useful in this very timely book.
Author: James Sneyd Publisher: Springer ISBN: 9783540254393 Category : Mathematics Languages : en Pages : 202
Book Description
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
Author: James Sneyd Publisher: Springer ISBN: 9783540809579 Category : Mathematics Languages : en Pages : 202
Book Description
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
Author: Wai Yiu Cheung Publisher: Academic Press ISBN: 1483281973 Category : Science Languages : en Pages : 385
Book Description
Molecular Biology: Calcium and Cell Function, Volume VI deals with several topics relating to calcium and cell function. This book consists of nine chapters. Chapter 1 describes the various peptides that recognize calmodulin in a calcium-dependent fashion. Chapter 2 updates the molecular and regulatory properties of calmodulin-dependent phosphodiesterase, while Chapter 3 reviews a calmodulin-dependent protein phosphatase. The studies on the biophysical characterization of calmodulin are summarized in Chapter 4. In Chapter 5, the studies on a calcium-dependent protease from human erythrocytes are presented. The problem of an uncontrolled level of calcium that often precipitates toxic consequences is considered in Chapter 6. The role of calcium in meiosis is elaborated in Chapter 7, followed by a discussion on calcium ion involved with the secretory process, emphasizing the secretion of insulin in Chapter 8. The last chapter deliberates the role of photosynthesis, a process that captures the solar energy and sustains all living systems. This publication is a good reference for biologists, medical practitioners, and students researching on the relation of calcium to the physiology and biochemistry of organisms and cells.
Author: Geneviève Dupont Publisher: Springer ISBN: 3319296477 Category : Mathematics Languages : en Pages : 453
Book Description
This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
Author: Nicholas Sperelakis Publisher: Academic Press ISBN: 148329367X Category : Science Languages : en Pages : 755
Book Description
A multi-authored and comprehensive text, Cell Physiology Source Book enables graduate students in various biological sub-disciplines to gain a thorough understanding of cell physiology. It begins with a reviewof the physical chemistry of solutions, protein structure, and membrane structure, and ends with an Appendix featuring reviews of electricity, electrochemistry, and cable properties of cells. In between, this book is loaded with information on membrane potentials, cell metabolism, signal transduction, transport physiology and pumps, membrane excitability and ion channels, synaptic transmission, sensory transduction, muscle contraction, excitation-contraction coupling, bioluminescence, photosynthesis, andplant cell physiology. This exhaustive work provides graduate students with detailed and authoritative coverage of nearly all aspects of cell physiology. Such broad coverage of this field within a single source makes for a unique text. Chapters written in a clear, concise, and didactic style, and appropriate reviews of basic physics and chemistry are among the many distinguishing features of this monumental treatise. Comprehensive source-book of cell physiology Authoritative and multi-authored by leading experts in the field Unique features include broad coverage and review of relevant physics, chemistry, and metabolism Clear, concise, and didactic Includes reviews of physical chemistry of solutions, protein structure, membrane structure, electrochemistry, and electricity Topic covered include plant cell physiology, photosynthesis, bioluminescence, effects of pressure, cilia, and flagellae Detailed treatise on ion channels and their regulation
Author: D. Marme
Author: D. Marme
Author: Gary Fiskum
Author: Michel Félétou
Author: James Sneyd
Author: Md. Shahidul Islam
Author: James Sneyd
Author: James Sneyd
Author: Wai Yiu Cheung
Author: Geneviève Dupont
Author: Nicholas Sperelakis