Author: Lynn Wecker
Publisher: Elsevier Health Sciences
ISBN: 0323596622
Category : Medical
Languages : en
Pages : 802
Book Description
Focusing on the essential aspects of pharmacology you need to know, Brody's Human Pharmacology, 6th Edition, keeps you fully up to date with all that's new in the field. Streamlined content, a new organizational approach, and thoroughly updated information ensure your grasp of key concepts and prepare you for exams. Nearly 500 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names reinforce your mastery of the information. The 6th Edition of this easy-to-use text is now fully up to date with: - NEW chapter devoted entirely to pharmacogenomics and personalized medicine. - NEW chapter on cannabinoids and their use for pain and other disorders, in light of recent legalization in many states. - NEW chapters on recent developments in the treatment of Alzheimer's disease, ADHD and the latest treatments for HIV. - NEW section on pain management. - NEW section in each chapter covering "Clinical Relevance for Healthcare Professionals" that provides important information specific to physical therapists, dentists and dental hygienists, and many other medical professionals. Plus these student-friendly features: - A new organizational approach, focusing on integration and systems-based learning. - Contributions from leading faculty who cover the most important aspects of pharmacology necessary for a basic understanding of the subject, including concepts, clinical applications, and side effects. - USMLE-style self-assessment questions at the end of every chapter, answers and rationales in the Appendix. Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com
Brody's Human Pharmacology
Author: Lynn Wecker
Publisher: Elsevier Health Sciences
ISBN: 0323596622
Category : Medical
Languages : en
Pages : 802
Book Description
Focusing on the essential aspects of pharmacology you need to know, Brody's Human Pharmacology, 6th Edition, keeps you fully up to date with all that's new in the field. Streamlined content, a new organizational approach, and thoroughly updated information ensure your grasp of key concepts and prepare you for exams. Nearly 500 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names reinforce your mastery of the information. The 6th Edition of this easy-to-use text is now fully up to date with: - NEW chapter devoted entirely to pharmacogenomics and personalized medicine. - NEW chapter on cannabinoids and their use for pain and other disorders, in light of recent legalization in many states. - NEW chapters on recent developments in the treatment of Alzheimer's disease, ADHD and the latest treatments for HIV. - NEW section on pain management. - NEW section in each chapter covering "Clinical Relevance for Healthcare Professionals" that provides important information specific to physical therapists, dentists and dental hygienists, and many other medical professionals. Plus these student-friendly features: - A new organizational approach, focusing on integration and systems-based learning. - Contributions from leading faculty who cover the most important aspects of pharmacology necessary for a basic understanding of the subject, including concepts, clinical applications, and side effects. - USMLE-style self-assessment questions at the end of every chapter, answers and rationales in the Appendix. Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com
Publisher: Elsevier Health Sciences
ISBN: 0323596622
Category : Medical
Languages : en
Pages : 802
Book Description
Focusing on the essential aspects of pharmacology you need to know, Brody's Human Pharmacology, 6th Edition, keeps you fully up to date with all that's new in the field. Streamlined content, a new organizational approach, and thoroughly updated information ensure your grasp of key concepts and prepare you for exams. Nearly 500 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names reinforce your mastery of the information. The 6th Edition of this easy-to-use text is now fully up to date with: - NEW chapter devoted entirely to pharmacogenomics and personalized medicine. - NEW chapter on cannabinoids and their use for pain and other disorders, in light of recent legalization in many states. - NEW chapters on recent developments in the treatment of Alzheimer's disease, ADHD and the latest treatments for HIV. - NEW section on pain management. - NEW section in each chapter covering "Clinical Relevance for Healthcare Professionals" that provides important information specific to physical therapists, dentists and dental hygienists, and many other medical professionals. Plus these student-friendly features: - A new organizational approach, focusing on integration and systems-based learning. - Contributions from leading faculty who cover the most important aspects of pharmacology necessary for a basic understanding of the subject, including concepts, clinical applications, and side effects. - USMLE-style self-assessment questions at the end of every chapter, answers and rationales in the Appendix. Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com
Brody's Human Pharmacology - E-Book
Author: Lynn Wecker
Publisher: Elsevier Health Sciences
ISBN: 0323075754
Category : Medical
Languages : en
Pages : 707
Book Description
Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names—as well as USMLE-style self-assessment questions with answers and rationales—reinforce your mastery of the information. A consistent style of writing—and more focused, concise content—provide for better learning of the essentials. Online access to Student Consult—where you’ll find 15 pharmacology animations...150 USMLE-style questions...and more—further enhances your study and prepares you for exams. Includes online access to Student Consult where you’ll find USMLE-style questions, animations showing the actions of various important toxins, and much more. Focuses on the essential aspects of pharmacology for a solid foundation of knowledge in the subject. Includes more than 480 full-color illustrations that explain key pharmacologic processes. Provides between 4 and 6 USMLE-style self-assessment questions at the end of each chapter—with answers and full explanations in the appendix—that help you prepare for exams and master the material. Uses a templated format that promotes more effective and efficient learning. Presents color-coded boxes in each chapter that emphasize key points. Features a clinical emphasis throughout on both the basic science of pharmacology and its clinical relevance. Includes new Gold Standard content on Student Consult with 200 Professional Drug Monographs for additional information on generic and brand names, mechanism of action, pharmacokinetics, indications and dosage, drug interactions, patient education and much more! Features a more consistent style of writing—as well as focused, concise content—for enhanced learning of the essentials. Presents chapters in a re-arranged order for a more logical approach to learning. Includes additional biochemistry and physiology information in the introduction for each section for greater understanding.
Publisher: Elsevier Health Sciences
ISBN: 0323075754
Category : Medical
Languages : en
Pages : 707
Book Description
Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names—as well as USMLE-style self-assessment questions with answers and rationales—reinforce your mastery of the information. A consistent style of writing—and more focused, concise content—provide for better learning of the essentials. Online access to Student Consult—where you’ll find 15 pharmacology animations...150 USMLE-style questions...and more—further enhances your study and prepares you for exams. Includes online access to Student Consult where you’ll find USMLE-style questions, animations showing the actions of various important toxins, and much more. Focuses on the essential aspects of pharmacology for a solid foundation of knowledge in the subject. Includes more than 480 full-color illustrations that explain key pharmacologic processes. Provides between 4 and 6 USMLE-style self-assessment questions at the end of each chapter—with answers and full explanations in the appendix—that help you prepare for exams and master the material. Uses a templated format that promotes more effective and efficient learning. Presents color-coded boxes in each chapter that emphasize key points. Features a clinical emphasis throughout on both the basic science of pharmacology and its clinical relevance. Includes new Gold Standard content on Student Consult with 200 Professional Drug Monographs for additional information on generic and brand names, mechanism of action, pharmacokinetics, indications and dosage, drug interactions, patient education and much more! Features a more consistent style of writing—as well as focused, concise content—for enhanced learning of the essentials. Presents chapters in a re-arranged order for a more logical approach to learning. Includes additional biochemistry and physiology information in the introduction for each section for greater understanding.
Pharmacology of the Skin II
Author:
Publisher: Springer Science & Business Media
ISBN: 3642740545
Category : Medical
Languages : en
Pages : 602
Book Description
The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Publisher: Springer Science & Business Media
ISBN: 3642740545
Category : Medical
Languages : en
Pages : 602
Book Description
The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Nurse Anesthesia E-Book
Author: John J. Nagelhout
Publisher: Elsevier Health Sciences
ISBN: 0323081010
Category : Medical
Languages : en
Pages : 1411
Book Description
Long respected as the most comprehensive nurse anesthesia resource available, this new edition continues the tradition of bringing together leading experts to create a balanced reference that applies scientific principles to today’s clinical anesthesia practice. Inside you’ll find a solid introduction to the equipment and patient care techniques unique to nurse anesthesia side-by-side with the cutting-edge research and application of evidence necessary to prepare you for tomorrow. Over 700 tables and boxes highlight the most essential information in a quick, easy-to-reference format. An easy-to-use organization with basic principles covered first, followed by individual chapters for each surgical specialty, ensures you have the information you need to build your knowledge. Over 650 figures of anatomy, nurse anesthesia procedures, and equipment enhance your understanding of complex information. Expert CRNA authors provide the most up-to-date and relevant clinical information you’ll use in daily practice. The latest pharmacology information on pharmacokinetics, drug delivery systems, opiate antagonists, and key induction drugs to keep you up-to-date. Thoroughly updated references make finding the latest and most important research in the field quick and simple. New chapters address legal issues, neonatal anesthesia, anesthesia education, clinical monitoring, regional anesthesia, unexpected complications, and more. Expanded coverage of chemistry and physics as well as immunology makes these difficult fundamental topics easier to understand and apply to everyday practice. Over 100 new images enhance your understanding of difficult anesthesia concepts.
Publisher: Elsevier Health Sciences
ISBN: 0323081010
Category : Medical
Languages : en
Pages : 1411
Book Description
Long respected as the most comprehensive nurse anesthesia resource available, this new edition continues the tradition of bringing together leading experts to create a balanced reference that applies scientific principles to today’s clinical anesthesia practice. Inside you’ll find a solid introduction to the equipment and patient care techniques unique to nurse anesthesia side-by-side with the cutting-edge research and application of evidence necessary to prepare you for tomorrow. Over 700 tables and boxes highlight the most essential information in a quick, easy-to-reference format. An easy-to-use organization with basic principles covered first, followed by individual chapters for each surgical specialty, ensures you have the information you need to build your knowledge. Over 650 figures of anatomy, nurse anesthesia procedures, and equipment enhance your understanding of complex information. Expert CRNA authors provide the most up-to-date and relevant clinical information you’ll use in daily practice. The latest pharmacology information on pharmacokinetics, drug delivery systems, opiate antagonists, and key induction drugs to keep you up-to-date. Thoroughly updated references make finding the latest and most important research in the field quick and simple. New chapters address legal issues, neonatal anesthesia, anesthesia education, clinical monitoring, regional anesthesia, unexpected complications, and more. Expanded coverage of chemistry and physics as well as immunology makes these difficult fundamental topics easier to understand and apply to everyday practice. Over 100 new images enhance your understanding of difficult anesthesia concepts.
Nurse Anesthesia
Author: John J. Nagelhout, CRNA, PhD, FAAN
Publisher: Elsevier Health Sciences
ISBN: 1455706124
Category : Medical
Languages : en
Pages : 1395
Book Description
Written specifically for nurse anesthetists, Nurse Anesthesia, 5th Edition provides comprehensive coverage of both scientific principles and evidence-based practice. It offers a complete overview of anatomy, physiology, pharmacology, and pathophysiology, and offers practical coverage of equipment and anesthesia management. This edition includes updated information on pharmacokinetics, clinical monitoring, drug delivery systems, and complications, and revises chapters on airway management and anesthesia for cardiac surgery. Written by leading nurse anesthesia experts John Nagelhout and Karen Plaus, this perennial bestseller prepares anesthesia students and CRNAs for today's clinical anesthesia practice. Over 650 figures of anatomy, nurse anesthesia procedures, and equipment depict complex concepts and information. An easy-to-use organization covers basic principles first, and builds on those with individual chapters for each surgical specialty. UPDATED references make it quick and simple to find the latest and most important research in the field. Over 700 tables and boxes highlight the most essential information in a quick, easy-to-reference format. Expert CRNA authors provide the current clinical information you'll use in daily practice. UPDATED pharmacology information includes pharmacokinetics, drug delivery systems, opiate antagonists, and key induction drugs. Over 100 NEW photos and illustrations enhance your understanding of difficult anesthesia concepts. UPDATED Airway Management and Anesthesia for Cardiac Surgery chapters are thoroughly revised. NEW coverage includes robotics, screening applications, and non-operating room best practices.
Publisher: Elsevier Health Sciences
ISBN: 1455706124
Category : Medical
Languages : en
Pages : 1395
Book Description
Written specifically for nurse anesthetists, Nurse Anesthesia, 5th Edition provides comprehensive coverage of both scientific principles and evidence-based practice. It offers a complete overview of anatomy, physiology, pharmacology, and pathophysiology, and offers practical coverage of equipment and anesthesia management. This edition includes updated information on pharmacokinetics, clinical monitoring, drug delivery systems, and complications, and revises chapters on airway management and anesthesia for cardiac surgery. Written by leading nurse anesthesia experts John Nagelhout and Karen Plaus, this perennial bestseller prepares anesthesia students and CRNAs for today's clinical anesthesia practice. Over 650 figures of anatomy, nurse anesthesia procedures, and equipment depict complex concepts and information. An easy-to-use organization covers basic principles first, and builds on those with individual chapters for each surgical specialty. UPDATED references make it quick and simple to find the latest and most important research in the field. Over 700 tables and boxes highlight the most essential information in a quick, easy-to-reference format. Expert CRNA authors provide the current clinical information you'll use in daily practice. UPDATED pharmacology information includes pharmacokinetics, drug delivery systems, opiate antagonists, and key induction drugs. Over 100 NEW photos and illustrations enhance your understanding of difficult anesthesia concepts. UPDATED Airway Management and Anesthesia for Cardiac Surgery chapters are thoroughly revised. NEW coverage includes robotics, screening applications, and non-operating room best practices.
A Practice of Anesthesia for Infants and Children
Author: Charles J. Cote, MD
Publisher: Elsevier Health Sciences
ISBN: 1437727921
Category : Medical
Languages : en
Pages : 1660
Book Description
Provide optimal anesthetic care to your young patients with A Practice of Anesthesia in Infants and Children, 5th Edition, by Drs. Charles J. Cote, Jerrold Lerman, and Brian J. Anderson. 110 experts representing 10 different countries on 6 continents bring you complete coverage of the safe, effective administration of general and regional anesthesia to infants and children - covering standard techniques as well as the very latest advances. Find authoritative answers on everything from preoperative evaluation through neonatal emergencies to the PACU. Get a free laminated pocket reference guide inside the book! Quickly review underlying scientific concepts and benefit from expert information on preoperative assessment and anesthesia management, postoperative care, emergencies, and special procedures. Stay on the cutting edge of management of emergence agitation, sleep-disordered breathing and postoperative vomiting; the use of new devices such as cuffed endotracheal tubes and new airway devices; and much more. Familiarize yourself with the full range of available new drugs, including those used for premedication and emergence from anesthesia. Benefit from numerous new figures and tables that facilitate easier retention of the material; new insights from neonatologists and neonatal pharmacologists; quick summaries of each chapter; and more than 1,000 illustrations that clarify key concepts. Access the entire text online, fully searchable, at www.expertconsult.com, plus an extensive video library covering simulation, pediatric airway management, burn injuries, ultra-sound guided regional anesthesia, and much more; and new online-only sections, tables and figures.
Publisher: Elsevier Health Sciences
ISBN: 1437727921
Category : Medical
Languages : en
Pages : 1660
Book Description
Provide optimal anesthetic care to your young patients with A Practice of Anesthesia in Infants and Children, 5th Edition, by Drs. Charles J. Cote, Jerrold Lerman, and Brian J. Anderson. 110 experts representing 10 different countries on 6 continents bring you complete coverage of the safe, effective administration of general and regional anesthesia to infants and children - covering standard techniques as well as the very latest advances. Find authoritative answers on everything from preoperative evaluation through neonatal emergencies to the PACU. Get a free laminated pocket reference guide inside the book! Quickly review underlying scientific concepts and benefit from expert information on preoperative assessment and anesthesia management, postoperative care, emergencies, and special procedures. Stay on the cutting edge of management of emergence agitation, sleep-disordered breathing and postoperative vomiting; the use of new devices such as cuffed endotracheal tubes and new airway devices; and much more. Familiarize yourself with the full range of available new drugs, including those used for premedication and emergence from anesthesia. Benefit from numerous new figures and tables that facilitate easier retention of the material; new insights from neonatologists and neonatal pharmacologists; quick summaries of each chapter; and more than 1,000 illustrations that clarify key concepts. Access the entire text online, fully searchable, at www.expertconsult.com, plus an extensive video library covering simulation, pediatric airway management, burn injuries, ultra-sound guided regional anesthesia, and much more; and new online-only sections, tables and figures.
Advances in Chromatography
Author: Eli Grushka
Publisher: CRC Press
ISBN: 1466569654
Category : Science
Languages : en
Pages : 335
Book Description
For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 51, the series editors have invited established, well-known chemists from across the globe to offer cutting-edge reviews on their areas of expertise—from theoretical aspects to novel and established applications of chromatographic techniques. Featured topics include Nonequilibrium Thermodynamics in Nonlinear Chromatography and Electrophoresis: Theory and Applications Biomimetic Chromatography: A Useful Tool in the Drug Discovery Process Solid-Phase Microextraction for In Vivo Pharmacokinetics and Other Stages of Drug Development Identification and Detection of Antibiotic Drugs and Their Degradation Products in Aquatic Samples Sample Preparation for Chromatographic Analysis Development of HPLC Retention Index QSAR Models for Nontargeted Metabolomics Thin Layer Chromatography with a Controlled Gas Phase Influencing on the Separation The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.
Publisher: CRC Press
ISBN: 1466569654
Category : Science
Languages : en
Pages : 335
Book Description
For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 51, the series editors have invited established, well-known chemists from across the globe to offer cutting-edge reviews on their areas of expertise—from theoretical aspects to novel and established applications of chromatographic techniques. Featured topics include Nonequilibrium Thermodynamics in Nonlinear Chromatography and Electrophoresis: Theory and Applications Biomimetic Chromatography: A Useful Tool in the Drug Discovery Process Solid-Phase Microextraction for In Vivo Pharmacokinetics and Other Stages of Drug Development Identification and Detection of Antibiotic Drugs and Their Degradation Products in Aquatic Samples Sample Preparation for Chromatographic Analysis Development of HPLC Retention Index QSAR Models for Nontargeted Metabolomics Thin Layer Chromatography with a Controlled Gas Phase Influencing on the Separation The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.
Infertility in the Male
Author: Larry I. Lipshultz
Publisher: Cambridge University Press
ISBN: 0521872898
Category : Health & Fitness
Languages : en
Pages : 691
Book Description
This extensively revised edition of the highly-respected reference book provides in-depth discussions on the latest developments in male reproductive medicine.
Publisher: Cambridge University Press
ISBN: 0521872898
Category : Health & Fitness
Languages : en
Pages : 691
Book Description
This extensively revised edition of the highly-respected reference book provides in-depth discussions on the latest developments in male reproductive medicine.
Brody's Human Pharmacology
Author: Lynn Wecker
Publisher: Mosby
ISBN: 9780323137461
Category :
Languages : en
Pages : 0
Book Description
Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names-as well as USMLE-style self-assessment questions with answers and rationales-reinforce your mastery of the information. A consistent style of writing-and more focused, concise content-provide for better learning of the essentials. Online access to Student Consult-where you'll find the complete contents of the book, fully searchable...Integration Links to bonus content in other Student Consult titles...15 pharmacology animations...150 USMLE-style questions...and more-further enhances your study and prepares you for exams.
Publisher: Mosby
ISBN: 9780323137461
Category :
Languages : en
Pages : 0
Book Description
Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names-as well as USMLE-style self-assessment questions with answers and rationales-reinforce your mastery of the information. A consistent style of writing-and more focused, concise content-provide for better learning of the essentials. Online access to Student Consult-where you'll find the complete contents of the book, fully searchable...Integration Links to bonus content in other Student Consult titles...15 pharmacology animations...150 USMLE-style questions...and more-further enhances your study and prepares you for exams.
Pharmacology of Intestinal Permeation I
Author:
Publisher: Springer Science & Business Media
ISBN: 3642695051
Category : Medical
Languages : en
Pages : 719
Book Description
The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200m ) through which the body is exposed to its environment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a "leaky" epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. "Permeability" is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines thebioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a significant alteration of the physiological process of intestinal permeation.
Publisher: Springer Science & Business Media
ISBN: 3642695051
Category : Medical
Languages : en
Pages : 719
Book Description
The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200m ) through which the body is exposed to its environment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a "leaky" epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. "Permeability" is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines thebioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a significant alteration of the physiological process of intestinal permeation.