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Author: Michael Okun Publisher: Books4patients ISBN: 9780692497418 Category : Languages : en Pages : 156
Book Description
Michael S. Okun, M.D. is internationally celebrated as both a neurologist and a leading researcher. He has often been referred to as, "the voice of the Parkinson's disease patient." He was honored at the White House in 2015 as a Champion of Change for Parkinson's disease. He has an international following on the National Parkinson Foundation's Ask the Doctor web-forum and he is a Professor of Neurology at the University of Florida Health Center for Movement Disorders and Neurorestoration. His many books and internet blog posts are brimming with up-to date and extremely practical information. This book is the sequel to his runaway bestseller, Parkinson's Treatment: 10 Secrets to a Happier Life, which was translated into over 20 languages. Dr. Okun is well known for infusing his readers with positivity and optimism. In his latest book he reveals the breakthroughs in Parkinson's disease that will pave the road to meaningful progress. In this book he reviews all of the recent breakthrough ideas and therapies in Parkinson's disease, and he reviews the knowledge gained which is extending far beyond a single drug or stem cell. He paints the broader and more exciting picture and reviews the portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior. He believes that patients and families with personal investments in Parkinson's disease should be informed and updated about all of these potential breakthrough therapies. This book informs, educates, and will inspire Parkinson's disease patients, family members, as well as health care professionals and scientists. As Dr. Okun points out, we will journey toward better treatments -- and one day a cure.
Author: Michael Okun Publisher: Books4patients ISBN: 9780692497418 Category : Languages : en Pages : 156
Book Description
Michael S. Okun, M.D. is internationally celebrated as both a neurologist and a leading researcher. He has often been referred to as, "the voice of the Parkinson's disease patient." He was honored at the White House in 2015 as a Champion of Change for Parkinson's disease. He has an international following on the National Parkinson Foundation's Ask the Doctor web-forum and he is a Professor of Neurology at the University of Florida Health Center for Movement Disorders and Neurorestoration. His many books and internet blog posts are brimming with up-to date and extremely practical information. This book is the sequel to his runaway bestseller, Parkinson's Treatment: 10 Secrets to a Happier Life, which was translated into over 20 languages. Dr. Okun is well known for infusing his readers with positivity and optimism. In his latest book he reveals the breakthroughs in Parkinson's disease that will pave the road to meaningful progress. In this book he reviews all of the recent breakthrough ideas and therapies in Parkinson's disease, and he reviews the knowledge gained which is extending far beyond a single drug or stem cell. He paints the broader and more exciting picture and reviews the portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior. He believes that patients and families with personal investments in Parkinson's disease should be informed and updated about all of these potential breakthrough therapies. This book informs, educates, and will inspire Parkinson's disease patients, family members, as well as health care professionals and scientists. As Dr. Okun points out, we will journey toward better treatments -- and one day a cure.
Author: Karen Brach Publisher: Independently Published ISBN: Category : Health & Fitness Languages : en Pages : 0
Book Description
Breakthroughs in Parkinson's Therapy: Neurodegenerative Insights and Treatment Strategies" emerges as an essential guide for countless individuals navigating the complexities of Parkinson's disease (PD), offering a beacon of hope through innovative therapy options and groundbreaking research insights.At the heart of this transformative work is an exploration of the latest advancements in Parkinson's therapy, including cutting-edge neurodegenerative insights and treatment strategies that have shown significant promise in altering the disease's trajectory. Despite these advances, there remains a critical gap in awareness and application among healthcare professionals, leaving many patients without access to potentially life-changing treatments. Designed with both individuals living with Parkinson's and their healthcare providers in mind, this book delves deep into the scientific underpinnings of novel therapeutic approaches. It presents a comprehensive overview of the current research landscape, exploring the mechanisms through which these new treatments exert their effects on the brain and offering a clear protocol for those interested in integrating these strategies into their care regimen. The urgency for neurologists, general practitioners, and Parkinson's specialists to familiarize themselves with these emerging therapies cannot be overstated. With Parkinson's disease continuing to challenge those it affects, the introduction of immediate, accessible, and innovative treatment options represents a pivotal shift towards improving the quality of life for many. Following the legacy of pioneers who have pushed the boundaries of Parkinson's research and treatment, "Breakthroughs in Parkinson's Therapy" not only sheds light on their groundbreaking work but also calls upon the medical community to embrace and further investigate these novel strategies. It underscores the necessity for ongoing research and funding to bring these therapies from the fringes of experimental medicine to the forefront of mainstream clinical practice. In a landscape yearning for hope and substantive progress, this book stands as a testament to the resilience of those affected by Parkinson's and the relentless pursuit of a future where managing and overcoming this neurodegenerative disease is within reach.
Author: Lucas G. Chase Publisher: Springer Science & Business Media ISBN: 1627032002 Category : Science Languages : en Pages : 458
Book Description
Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
Author: Publisher: Elsevier ISBN: 0444642609 Category : Science Languages : en Pages : 578
Book Description
Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields
Author: J.W. Langston Publisher: IOS Press ISBN: 1614993327 Category : Medical Languages : en Pages : 264
Book Description
In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale... It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down... it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks
Author: Ray Dorsey Publisher: PublicAffairs ISBN: 1541724496 Category : Health & Fitness Languages : en Pages : 271
Book Description
In this "must-read" guide (Lonnie Ali), four leading doctors and advocates offer a bold action plan to prevent, care for, and treat Parkinson's disease-one of the great health challenges of our time. Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of impacted patients has doubled to more than six million over the last twenty-five years and is projected to double again by 2040. Harmful pesticides that increase the risk of Parkinson's continue to proliferate, many people remain undiagnosed and untreated, research funding stagnates, and the most effective treatment is now a half century old. In Ending Parkinson's Disease, four top experts provide a plan to help prevent Parkinson's, improve care and treatment, and end the silence associated with this devastating disease.
Author: Publisher: Elsevier ISBN: 0444537511 Category : Psychology Languages : en Pages : 369
Book Description
This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles. - Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Author: Renata Ramina Pessoa Publisher: ISBN: 9781022904576 Category : Medical Languages : en Pages : 0
Book Description
Techniques and Transformations: Advances in Parkinson's Disease Research is a comprehensive collection of scientific journal articles that explores the latest discoveries and innovations in the field of Parkinson's disease (PD). This anthology delves into a diverse range of topics, from the molecular underpinnings of neurodegeneration to groundbreaking therapies aimed at disease modification and symptom management. Readers will find in-depth reviews on the usage and efficacy of apomorphine, investigations into experimental approaches targeting the progression of PD, and discussions on neuroprotective strategies and their clinical challenges. The book also examines non-pharmacologic interventions such as cognitive behavioral therapy for insomnia, the potential of gene and cell replacement therapies, and the role of genetic variability in treatment outcomes. Additionally, it addresses the contributions of gut bacteria and diet to drug pharmacokinetics, providing a holistic view of patient care beyond the neurological aspects. Each article is enriched with experimental studies and clinical trial data, offering a thorough and dynamic picture of current and future possibilities in Parkinson's disease treatment. Aimed at researchers, clinicians, and anyone interested in the relentless pursuit of understanding and combating PD, this collection is both an educational resource and an inspirational beacon for ongoing advancements in the field. Quality Research Publishing is dedicated to making knowledge more accessible to the general public by curating a topical compilation of the latest research on various subjects and providing plain language summaries. Each of the articles in this book is available individually and digitally without cost. However, we believe it is important for the contextualizing and sharing of educational and scientific work to curate this research in a way that is understandable and helpful to the average person seeking deeper knowledge of a particular subject. The research articles compiled for this book were published under a permissive Creative Commons license, are in the public domain, or have no copyright restrictions, permitting their use in this book. If you have questions about the licensing of any article, please visit qualityresearchpublishing.com.
Author: Michael Okun
Author: Michael Okun
Author: Karen Brach
Author: Michael S. Okun
Author: Lucas G. Chase
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Author: J.W. Langston
Author: James Parkinson
Author: Ray Dorsey
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Author: Renata Ramina Pessoa