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Author: Gert Fricker Publisher: Springer ISBN: 3662437872 Category : Science Languages : en Pages : 169
Book Description
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Author: Gert Fricker Publisher: Springer ISBN: 3662437872 Category : Science Languages : en Pages : 169
Book Description
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Author: Marilyn J. Cipolla Publisher: Biota Publishing ISBN: 1615047239 Category : Medical Languages : en Pages : 82
Book Description
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
Author: Janet Jones Publisher: Trafalgar Square Books ISBN: 1646010272 Category : Pets Languages : en Pages : 455
Book Description
An eye-opening game-changer of a book that sheds new light on how horses learn, think, perceive, and perform, and explains how to work with the horse’s brain instead of against it. In this illuminating book, brain scientist and horsewoman Janet Jones describes human and equine brains working together. Using plain language, she explores the differences and similarities between equine and human ways of negotiating the world. Mental abilities—like seeing, learning, fearing, trusting, and focusing—are discussed from both human and horse perspectives. Throughout, true stories of horses and handlers attempting to understand each other—sometimes successfully, sometimes not—help to illustrate the principles. Horsemanship of every kind depends on mutual interaction between equine and human brains. When we understand the function of both, we can learn to communicate with horses on their terms instead of ours. By meeting horses halfway, we achieve many goals. We improve performance. We save valuable training time. We develop much deeper bonds with our horses. We handle them with insight and kindness instead of force or command. We comprehend their misbehavior in ways that allow solutions. We reduce the human mistakes we often make while working with them. Instead of working against the horse’s brain, expecting him to function in unnatural and counterproductive ways, this book provides the information needed to ride with the horse’s brain. Each principle is applied to real everyday issues in the arena or on the trail, often illustrated with true stories from the author’s horse training experience. Horse Brain, Human Brain offers revolutionary ideas that should be considered by anyone who works with horses.
Author: Marcus E. Raichle Publisher: Oxford University Press ISBN: 0199358990 Category : Medical Languages : en Pages : 241
Book Description
Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso's pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging. Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso's sophisticated experiments were to neuroscience what surgeon William Beaumont's in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso's rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author's remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso's life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso's work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso's pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.
Author: Robin Becker Publisher: Harper Collins ISBN: 0062000306 Category : Fiction Languages : en Pages : 193
Book Description
“A witty and unexpected take on the zombie genre; I had a great time.” —Charlaine Harris, #1 New York Times bestselling author of the Sookie Stackhouse novels Subtitled “A Zombie Memoir,” Brains looks at America’s favorite walking-dead flesh-eaters from an audaciously original and deliciously gruesome new perspective. Debut author Robin Becker blazes new ground with this story of former college professor-cum-sentient zombie Jack Barnes, who recounts the tale of the resistance he organized in the wake of the recent zombie apocalypse. World War Z; Shaun of the Dead;Pride, Prejudice, and Zombies… Becker tops them all with Brains—a witty, tasty treat for anyone who every spent a midnight glued to a classic George A. Romero zombie epic!
Author: Sharon Dirckx Publisher: The Good Book Company ISBN: 1784984035 Category : Science Languages : en Pages : 146
Book Description
Looking at the body, mind and soul to answer the question: What exactly is a human being? Modern research is uncovering more and more detail of what our brain is and how it works. We are living, thinking creatures who carry around with us an amazing organic supercomputer in our heads. But what is the relationship between our brains and our minds-and ultimately our sense of identity as a person? Are we more than machines? Is free-will an illusion? Do we have a soul? Brain Imaging Scientist Sharon Dirckx lays out the current understanding of who we are from biologists, philosophers, theologians and psychologists, and points towards a bigger picture that suggests answers to the fundamental questions of our existence. Not just "What am I?", but "Who am I?"-and "Why am I?" Read this book to gain valuable insight into what modern research is telling us about ourselves, or to give a sceptical friend to challenge the idea that we are merely material beings living in a material world.
Author: Barbara K. Lipska Publisher: HarperCollins ISBN: 1328787273 Category : Biography & Autobiography Languages : en Pages : 213
Book Description
In the tradition of My Stroke of Insight and Brain on Fire, this powerful memoir recounts Barbara Lipska's deadly brain cancer and explains its unforgettable lessons about the brain and mind. Neuroscientist Lipska was diagnosed early in 2015 with metastatic melanoma in her brain's frontal lobe. As the cancer progressed and was treated, she experienced behavioral and cognitive symptoms connected to a range of mental disorders, including dementia and her professional specialty, schizophrenia. Lipska's family and associates were alarmed by the changes in her behavior, which she failed to acknowledge herself. Gradually, after a course of immunotherapy, Lipska returned to normal functioning, amazingly recalled her experience, and through her knowledge of neuroscience identified the ways in which her brain changed during treatment. Lipska admits her condition was unusual; after recovery she was able to return to her research and resume her athletic training and compete in a triathalon. Most patients with similar brain cancers rarely survive to describe their ordeal. Lipska's memoir, coauthored with journalist Elaine McArdle, shows that strength and courage but also an encouraging support network are vital to recovery.
Author: Ginny Smith Publisher: Bloomsbury Publishing ISBN: 1472969367 Category : Psychology Languages : en Pages : 337
Book Description
A NEW SCIENTIST BOOK OF THE YEAR From adrenaline to dopamine, our lives are shaped by the chemicals that control us. They are the hormones and neurotransmitters that our brains run on, and Overloaded looks at the roles they play in all aspects of our experiences, from how we make decisions, who we love, what we remember to basic survival drives such as hunger, fear and sleep. Author Ginny Smith explores what these tiny molecules do: what roles do cortisol and adrenaline play in memory formation? How do hormones and neurotransmitters affect the trajectory of our romantic relationships? Ginny meets scientists at the cutting-edge of brain chemistry research who are uncovering unexpected connections between these crucial chemicals. An eye-opening route through the remarkable world of neuro-transmitters, Overloaded unveils the chemicals inside each of us that touch every facet of our lives.
Author: Lisa Feldman Barrett Publisher: Houghton Mifflin ISBN: 0358157145 Category : Science Languages : en Pages : 197
Book Description
From the author of How Emotions Are Made, a myth-busting primer on the brain, in the tradition of Seven Brief Lessons on Physics and Astrophysics for People in a Hurry
Author: Gert Fricker
Author: Gert Fricker
Author: Marilyn J. Cipolla
Author: Janet Jones
Author: David Ogilvy
Author: Marcus E. Raichle
Author: Robin Becker
Author: Sharon Dirckx
Author: Barbara K. Lipska
Author: Ginny Smith
Author: Lisa Feldman Barrett