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Biophysics of DNA

Biophysics of DNA PDF Author: Alexander Vologodskii
Publisher: Cambridge University Press
ISBN: 1107034930
Category : Science
Languages : en
Pages : 279

Book Description
This book surveys the last sixty years of research in the rapidly advancing field of DNA biophysics, addressing key questions and facilitating further research.

Biophysics of DNA

Biophysics of DNA PDF Author: Alexander Vologodskii
Publisher: Cambridge University Press
ISBN: 1107034930
Category : Science
Languages : en
Pages : 279

Book Description
This book surveys the last sixty years of research in the rapidly advancing field of DNA biophysics, addressing key questions and facilitating further research.

Biophysics of DNA-Protein Interactions

Biophysics of DNA-Protein Interactions PDF Author: Mark C. Williams
Publisher: Springer
ISBN: 9781461426950
Category : Science
Languages : en
Pages : 350

Book Description
Depite the rapid expansion of the field of biophysics, there are very few books that comprehensively treat specific topics in this area. Recently, the field of single molecule biophysics has developed very quickly, and a few books specifically treating single molecule methods are beginning to appear. However, the promise of single molecule biophysics is to contribute to the understanding of specific fields of biology using new methods. This book would focus on the specific topic of the biophysics of DNA-protein interactions, and would include the use of new approaches, including both bulk methods as well as single molecule methods. This would make the book attractive to anyone working in the general area of DNA-protein interactions, which is of course a much wider market than just single molecule biophysicists or even biophysicists. The subject of the book will be the biophysics of DNA-protein interactions, and will include new methods and results that describe the physical mechanism by which proteins interact with DNA. For example, there has been much recent work on the mechanism by which proteins search for specific binding sites on DNA. A few chapters will be devoted to experiments and theory that shed light on this important problem. We will also cover proteins that alter DNA properties to facilitate interactions important for transcription or replication. Another section of the book will cover the biophysical mechanism by which motor proteins interact with DNA. Finally, we will cover larger protein-DNA complexes, such as replication forks, recombination complexes, DNA repair interactions, and their chromatin context.

Introduction to Protein-DNA Interactions

Introduction to Protein-DNA Interactions PDF Author: Gary Stormo
Publisher:
ISBN: 9781936113491
Category : Science
Languages : en
Pages : 198

Book Description
One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein-DNA interactions.

DNA Structure and Function

DNA Structure and Function PDF Author: Richard R. Sinden
Publisher: Elsevier
ISBN: 0080571735
Category : Science
Languages : en
Pages : 423

Book Description
DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics. - Explains basic DNA Structure and function clearly and simply - Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations - Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure - Highlights key experiments and ideas within boxed sections - Illustrated with 150 diagrams and figures that convey structural and experimental concepts

Molecular Biology of the Cell

Molecular Biology of the Cell PDF Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

Book Description


Life's Ratchet

Life's Ratchet PDF Author: Peter M. Hoffmann
Publisher:
ISBN: 0465022537
Category : Science
Languages : en
Pages : 290

Book Description
Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.

Nonlinear Physics of DNA

Nonlinear Physics of DNA PDF Author: Ludmila V. Yakushevich
Publisher: John Wiley & Sons
ISBN: 3527604731
Category : Science
Languages : de
Pages : 205

Book Description
The first edition of this book was the first on the physics of DNA to go beyond the simple (simplified) 'linear' approach, and it has since been found that the inclusion of nonlinear effects leads to a significantly improved interpretation of experimental data. This new edition naturally retains this approach, but has been completely revised, updated and expanded to cover recent developments. Beginning with introductory chapters on DNA structure and dynamics, the book also includes a comparison between linear and nonlinear approaches to the DNA molecule, a chapter devoted to the statistics of nonlinear excitations of DNA, and examples for the interpretation of experimental data on the dynamics of DNA in terms of nonlinear theory. Essential reading for researchers in biophysics and nonlinear physics, allowing biologists, chemists and physicists to continue developing new and improved techniques of investigating the DNA molecule.

Biophysics

Biophysics PDF Author: William Bialek
Publisher: Princeton University Press
ISBN: 1400845572
Category : Science
Languages : en
Pages : 653

Book Description
A physicist's guide to the phenomena of life Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology—from the discovery of DNA's structure to imaging of the human brain—have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles—the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. Covers a range of biological phenomena from the physicist's perspective Features 200 problems Draws on statistical mechanics, quantum mechanics, and related mathematical concepts Includes an annotated bibliography and detailed appendixes

Nucleic Acid Research

Nucleic Acid Research PDF Author: Kiyoshi Mizobuchi
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 618

Book Description
Nucleic Acid Research: Future Development reflects the exchange of ideas and information among the participants of """"The Future of Nucleic Acid Research"""" symposium held at Kyoto on December 1981. This publication aims to extend the ideas presented in the symposium and to provide facts that can answer various scientific questions, particularly, in molecular biology. The book is divided into five parts. It explains the structure of DNA and chromosome and the interaction of nucleic acids with proteins. It also discusses the gene organization of prokaryotes as well as the gene expressions i ...

Biophysics of RNA-Protein Interactions

Biophysics of RNA-Protein Interactions PDF Author: Chirlmin Joo
Publisher: Springer Nature
ISBN: 1493997262
Category : Science
Languages : en
Pages : 249

Book Description
RNA molecules play key roles in all aspects of cellular life, but to do so efficiently, they must work in synergism with proteins. This book addresses how proteins and RNA interact to carry out biological functions such as protein synthesis, regulation of gene expression, genome defense, liquid phase separation and more. The topics addressed in this volume will appeal to researchers in biophysics, biochemistry and structural biology. The book is a useful resource for anybody interested in elucidating the molecular mechanisms and discrete properties of RNA-protein complexes. Included are reviews of key systems such as microRNA and CRISPR/Cas that exemplify how RNA and proteins work together to perform their biological function. Also covered are techniques ranging from single molecule fluorescence and force spectroscopy to crystallography, cryo-EM microscopy, and kinetic modeling.