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Author: United Nations. Scientific Committee on the Effects of Atomic Radiation Publisher: ISBN: Category : Languages : en Pages : 35
Book Description
At its fifty-ninth session (21-25 May 2012), the Scientific Committee considered a short review document on the biological mechanisms of radiation actions at low doses. That document, unlike the Committee's standard full evaluations, was not intended to be comprehensive; it was rather intended to highlight major advances in the field that would provide guidance for developing the Committee's future programme of work. The document concludes that understanding of the mechanisms of so-called non-targeted delayed effects is improving and that there is some evidence for differential responses in gene and protein expression for high- and low-dose radiation exposures, but there is a lack of consistency and coherence among reports. There is as yet no indication of a causal association of those phenomena with radiation-related disease. With regard to immune response and inflammatory reactions, there is a clearer association with disease, but there is no consensus on the impact of radiation exposure, particularly at low doses, on those physiological processes. While the document focuses on mechanisms relevant to carcinogenesis, some of the processes considered may be relevant for tissue reactions, and improved understanding may therefore be helpful for assessing the potential risk of non-cancer diseases at low and protracted exposures.
Author: United Nations. Scientific Committee on the Effects of Atomic Radiation Publisher: ISBN: Category : Languages : en Pages : 35
Book Description
At its fifty-ninth session (21-25 May 2012), the Scientific Committee considered a short review document on the biological mechanisms of radiation actions at low doses. That document, unlike the Committee's standard full evaluations, was not intended to be comprehensive; it was rather intended to highlight major advances in the field that would provide guidance for developing the Committee's future programme of work. The document concludes that understanding of the mechanisms of so-called non-targeted delayed effects is improving and that there is some evidence for differential responses in gene and protein expression for high- and low-dose radiation exposures, but there is a lack of consistency and coherence among reports. There is as yet no indication of a causal association of those phenomena with radiation-related disease. With regard to immune response and inflammatory reactions, there is a clearer association with disease, but there is no consensus on the impact of radiation exposure, particularly at low doses, on those physiological processes. While the document focuses on mechanisms relevant to carcinogenesis, some of the processes considered may be relevant for tissue reactions, and improved understanding may therefore be helpful for assessing the potential risk of non-cancer diseases at low and protracted exposures.
Author: John Lett Publisher: ISBN: 9780120354146 Category : Medical Languages : en Pages : 348
Book Description
Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emph ...
Author: Robert C. Bast, Jr. Publisher: John Wiley & Sons ISBN: 111900084X Category : Medical Languages : en Pages : 2004
Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation Publisher: National Academies Press ISBN: 0309133343 Category : Science Languages : en Pages : 422
Book Description
This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Author: Elena Burlakova Publisher: CRC Press ISBN: 9067644145 Category : Science Languages : en Pages : 443
Book Description
The papers collected in this book show the results of investigations performed by Russian scientists in the field of low dose irradiation action. It is confirmed that low doses do have effects on the human organism and the environment and that the most serious consequences are observed in the far post-irradiation period. This branch of radiobiology, which developed after the Chernobyl accident and studied its consequences, is discussed in detail. The main part of reviews and articles is devoted to the aspects of low dose effects on the human and animal genome and far post-irradiation consequences. New details of mechanisms of low dose action are shown and methods of their determination are discussed. Furthermore, the adaptive response of organisms and the low dose effects on the immune system are demonstrated. Also, the difference between protection mechanisms against low dose irradiation and against high dose irradiation is shown and proved.
Author: National Research Council Publisher: National Academies ISBN: 0309039959 Category : Science Languages : en Pages : 436
Book Description
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author: Oddvar F. Nygaard Publisher: ISBN: 9780120354160 Category : Science Languages : en Pages : 336
Book Description
Advances in Radiation Biology, Volume 6: Effects of Low Dose and Low Dose Rate Radiation examines the biological effects of low dose and low dose rate ionizing radiation on a broad scale, covering various articles from microdosimetry to analyses of human responses. Estimates of the effects on humans from low doses or from sustained exposures to low dose rates of ionizing radiations are of critical importance for the assessment of radiation risks under occupational and environmental conditions. This book consists of such knowledge that is essential for radiation protection and governmental regu...
Author: United Nations Scientific Committee on the Effects of Atomic Radiation Publisher: ISBN: 9789210010054 Category : Languages : en Pages : 0
Book Description
The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) established by the General Assembly in 1955 assesses the levels and effects of exposure to ionizing radiation on human health and the environment. This is the third of four volumes of scientific annexes provide the supporting scientific deliberations for the UNSCEAR 2020/2021 report to the General Assembly. Annex C "Biological mechanisms relevant for the inference of cancer risks from low dose and low-dose rate radiation" synthesizes the current knowledge on biological mechanisms of radiation actions at low doses and low-dose-rates, and assesses the implications for understanding the processes of cancer development after exposure to ionizing radiation, and for dose-response relationships of radiation-induced cancers.
Author: I︠U︡riĭ Borisovich Kudri︠a︡shov Publisher: Nova Publishers ISBN: 9781600212802 Category : Science Languages : en Pages : 372
Book Description
The book is concerned with features analysis of radiation damage to living matter at different levels of its organisation, beginning from the molecular level. The general theory of the mechanisms of biological action of radiation based on four logically connected principles of radiation biology is presented for the first time. The book contains abundant material on primary and secondary processes of the response of living systems to radiation, the mechanisms of direct and indirect action of radiation through radiolysis of water and lipids; a detailed consideration of the theory of targets (DNA and biological membranes) and the problems of high- and low-dose irradiation in the context of present-day. The systemic response of the cell to irradiation (oxidative stress, endogenous background radioresistance, damage and repair of biological membranes and DNA, systemic protection against radiation) is approximated. Presentation of these important problems is preceded by an up-to-date evaluation of some aspects regarding dosimetry of ionising radiation.
Author: United Nations. Scientific Committee on the Effects of Atomic Radiation
Author: United Nations. Scientific Committee on the Effects of Atomic Radiation
Author: John Lett
Author: L. Kh Eidus
Author: Robert C. Bast, Jr.
Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Author: Elena Burlakova
Author: National Research Council
Author: Oddvar F. Nygaard
Author: United Nations Scientific Committee on the Effects of Atomic Radiation
Author: I︠U︡riĭ Borisovich Kudri︠a︡shov