Bayesian Cost-Effectiveness Analysis with the R package BCEA PDF Download

Author: Gianluca Baio
Publisher: Springer
ISBN: 3319557181
Category : Medical
Languages : en
Pages : 168

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Book Description
The book provides a description of the process of health economic evaluation and modelling for cost-effectiveness analysis, particularly from the perspective of a Bayesian statistical approach. Some relevant theory and introductory concepts are presented using practical examples and two running case studies. The book also describes in detail how to perform health economic evaluations using the R package BCEA (Bayesian Cost-Effectiveness Analysis). BCEA can be used to post-process the results of a Bayesian cost-effectiveness model and perform advanced analyses producing standardised and highly customisable outputs. It presents all the features of the package, including its many functions and their practical application, as well as its user-friendly web interface. The book is a valuable resource for statisticians and practitioners working in the field of health economics wanting to simplify and standardise their workflow, for example in the preparation of dossiers in support of marketing authorisation, or academic and scientific publications.

Author: Gianluca Baio
Publisher: CRC Press
ISBN: 1439895554
Category : Mathematics
Languages : en
Pages : 246

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Book Description
Health economics is concerned with the study of the cost-effectiveness of health care interventions. This book provides an overview of Bayesian methods for the analysis of health economic data. After an introduction to the basic economic concepts and methods of evaluation, it presents Bayesian statistics using accessible mathematics. The next chapters describe the theory and practice of cost-effectiveness analysis from a statistical viewpoint, and Bayesian computation, notably MCMC. The final chapter presents three detailed case studies covering cost-effectiveness analyses using individual data from clinical trials, evidence synthesis and hierarchical models and Markov models. The text uses WinBUGS and JAGS with datasets and code available online.

Author: Nancy Devlin
Publisher: Springer Nature
ISBN: 3030476227
Category : Medical
Languages : en
Pages : 114

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Book Description
This open access book is the first published guide about how to analyse data produced by the EQ-5D, one of the most widely used Patient Reported Outcomes questionnaires world wide. The authors provide practical, clear and comprehensive guidance in five concise chapters. Following an overview of the EQ-5D and its analysis, we describe how the questionnaire data – the EQ-5D profile and EQ VAS – can be analysed in different ways to generate important insights into peoples’ health. We then show how the value sets which accompany the EQ-5D can be applied to summarise patients’ data. The final chapter deals with advanced topics, including the use of Minimally Important Differences, case-mix adjustment, mapping, and more. This book is essential for those new to analyzing EQ-5D data and will be also be valuable for those with more experience. The methods can be applied to any EQ-5D instrument (for example, the three- and five-level and Youth versions) and many of the methods described will be equally relevant to other Patient Reported Outcomes instruments.

Author: Elias Moreno
Publisher: CRC Press
ISBN: 1351744364
Category : Mathematics
Languages : en
Pages : 217

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Book Description
Cost-effectiveness analysis is becoming an increasingly important tool for decision making in the health systems. Cost-Effectiveness of Medical Treatments formulates the cost-effectiveness analysis as a statistical decision problem, identifies the sources of uncertainty of the problem, and gives an overview of the frequentist and Bayesian statistical approaches for decision making. Basic notions on decision theory such as space of decisions, space of nature, utility function of a decision and optimal decisions, are explained in detail using easy to read mathematics. Features Focuses on cost-effectiveness analysis as a statistical decision problem and applies the well-established optimal statistical decision methodology. Discusses utility functions for cost-effectiveness analysis. Enlarges the class of models typically used in cost-effectiveness analysis with the incorporation of linear models to account for covariates of the patients. This permits the formulation of the group (or subgroup) theory. Provides Bayesian procedures to account for model uncertainty in variable selection for linear models and in clustering for models for heterogeneous data. Model uncertainty in cost-effectiveness analysis has not been considered in the literature. Illustrates examples with real data. In order to facilitate the practical implementation of real datasets, provides the codes in Mathematica for the proposed methodology. The motivation for the book is to make the achievements in cost-effectiveness analysis accessible to health providers, who need to make optimal decisions, to the practitioners and to the students of health sciences. Elías Moreno is Professor of Statistics and Operational Research at the University of Granada, Spain, Corresponding Member of the Royal Academy of Sciences of Spain, and elect member of ISI. Francisco José Vázquez-Polo is Professor of Mathematics and Bayesian Methods at the University of Las Palmas de Gran Canaria, and Head of the Department of Quantitative Methods. Miguel Ángel Negrín is Senior Lecturer in the Department of Quantitative Methods at the ULPGC. His main research topics are Bayesian methods applied to Health Economics, economic evaluation and cost-effectiveness analysis, meta-analysis and equity in the provision of healthcare services.

Author: Jean-Michel Marin
Publisher: Springer Science & Business Media
ISBN: 1461486874
Category : Computers
Languages : en
Pages : 305

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Book Description
This Bayesian modeling book provides a self-contained entry to computational Bayesian statistics. Focusing on the most standard statistical models and backed up by real datasets and an all-inclusive R (CRAN) package called bayess, the book provides an operational methodology for conducting Bayesian inference, rather than focusing on its theoretical and philosophical justifications. Readers are empowered to participate in the real-life data analysis situations depicted here from the beginning. Special attention is paid to the derivation of prior distributions in each case and specific reference solutions are given for each of the models. Similarly, computational details are worked out to lead the reader towards an effective programming of the methods given in the book. In particular, all R codes are discussed with enough detail to make them readily understandable and expandable. Bayesian Essentials with R can be used as a textbook at both undergraduate and graduate levels. It is particularly useful with students in professional degree programs and scientists to analyze data the Bayesian way. The text will also enhance introductory courses on Bayesian statistics. Prerequisites for the book are an undergraduate background in probability and statistics, if not in Bayesian statistics.

Author: Anna Heath
Publisher: CRC Press
ISBN: 1003825583
Category : Mathematics
Languages : en
Pages : 280

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Book Description
Value of Information for Healthcare Decision-Making introduces the concept of Value of Information (VOI) use in health policy decision-making to determine the sensitivity of decisions to assumptions, and to prioritise and design future research. These methods, and their use in cost-effectiveness analysis, are increasingly acknowledged by health technology assessment authorities as vital. Key Features: Provides a comprehensive overview of VOI Simplifies VOI Showcases state-of-the-art techniques for computing VOI Includes R statistical software package Provides results when using VOI methods Uses realistic decision model to illustrate key concepts The primary audience for this book is health economic modellers and researchers, in industry, government, or academia, who wish to perform VOI analysis in health economic evaluations. It is relevant for postgraduate researchers and students in health economics or medical statistics who are required to learn the principles of VOI or undertake VOI analyses in their projects. The overall goal is to improve the understanding of these methods and make them easier to use.

Author: Pierre-Andre Cornillon
Publisher: CRC Press
ISBN: 1439881456
Category : Mathematics
Languages : en
Pages : 322

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Book Description
Although there are currently a wide variety of software packages suitable for the modern statistician, R has the triple advantage of being comprehensive, widespread, and free. Published in 2008, the second edition of Statistiques avec R enjoyed great success as an R guidebook in the French-speaking world. Translated and updated, R for Statistics includes a number of expanded and additional worked examples. Organized into two sections, the book focuses first on the R software, then on the implementation of traditional statistical methods with R. Focusing on the R software, the first section covers: Basic elements of the R software and data processing Clear, concise visualization of results, using simple and complex graphs Programming basics: pre-defined and user-created functions The second section of the book presents R methods for a wide range of traditional statistical data processing techniques, including: Regression methods Analyses of variance and covariance Classification methods Exploratory multivariate analysis Clustering methods Hypothesis tests After a short presentation of the method, the book explicitly details the R command lines and gives commented results. Accessible to novices and experts alike, R for Statistics is a clear and enjoyable resource for any scientist. Datasets and all the results described in this book are available on the book’s webpage at http://www.agrocampus-ouest.fr/math/RforStat

Author: Emmanuel Lesaffre
Publisher: CRC Press
ISBN: 1351718665
Category : Medical
Languages : en
Pages : 561

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Book Description
Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients. This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers: Theory, methods, applications, and computing Bayesian biostatistics for clinical innovative designs Adding value with Real World Evidence Opportunities for rare, orphan diseases, and pediatric development Applied Bayesian biostatistics in manufacturing Decision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.

Author: James E. Monogan III
Publisher: Springer
ISBN: 3319234463
Category : Social Science
Languages : en
Pages : 248

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Book Description
This book provides a narrative of how R can be useful in the analysis of public administration, public policy, and political science data specifically, in addition to the social sciences more broadly. It can serve as a textbook and reference manual for students and independent researchers who wish to use R for the first time or broaden their skill set with the program. While the book uses data drawn from political science, public administration, and policy analyses, it is written so that students and researchers in other fields should find it accessible and useful as well. By the end of the first seven chapters, an entry-level user should be well acquainted with how to use R as a traditional econometric software program. The remaining four chapters will begin to introduce the user to advanced techniques that R offers but many other programs do not make available such as how to use contributed libraries or write programs in R. The book details how to perform nearly every task routinely associated with statistical modeling: descriptive statistics, basic inferences, estimating common models, and conducting regression diagnostics. For the intermediate or advanced reader, the book aims to open up the wide array of sophisticated methods options that R makes freely available. It illustrates how user-created libraries can be installed and used in real data analysis, focusing on a handful of libraries that have been particularly prominent in political science. The last two chapters illustrate how the user can conduct linear algebra in R and create simple programs. A key point in these chapters will be that such actions are substantially easier in R than in many other programs, so advanced techniques are more accessible in R, which will appeal to scholars and policy researchers who already conduct extensive data analysis. Additionally, the book should draw the attention of students and teachers of quantitative methods in the political disciplines.

Author: Parteek Bhatia
Publisher: Cambridge University Press
ISBN: 110858585X
Category : Computers
Languages : en
Pages :

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Book Description
Written in lucid language, this valuable textbook brings together fundamental concepts of data mining and data warehousing in a single volume. Important topics including information theory, decision tree, Naïve Bayes classifier, distance metrics, partitioning clustering, associate mining, data marts and operational data store are discussed comprehensively. The textbook is written to cater to the needs of undergraduate students of computer science, engineering and information technology for a course on data mining and data warehousing. The text simplifies the understanding of the concepts through exercises and practical examples. Chapters such as classification, associate mining and cluster analysis are discussed in detail with their practical implementation using Weka and R language data mining tools. Advanced topics including big data analytics, relational data models and NoSQL are discussed in detail. Pedagogical features including unsolved problems and multiple-choice questions are interspersed throughout the book for better understanding.